Sentences with phrase «tested drugs designed»

And there is a big roadblock to testing drugs designed to induce tolerance: It is hard to know if they work unless immunosuppressant drugs are withdrawn, and that would risk rejection of the transplant.

Not exact matches

In December, Tehrani signed a deal with GlaxoSmithKline that will allow the pharmaceutical giant to test at least four of its drug candidates on a Zymeworks - designed platform, which combines a computer simulation with a way of engineering protein molecules and allows products to be refined before they move to expensive clinical trials.

Other sources provide services to keep costs low: Science Exchange connects scientists with experts; and Transcriptic is a cloud - based biotech lab testing experimental drugs, while Gingo Bioworks designs custom microbes for customers.

This spring, tech manufacturer Intel will lead several partner firms, including Johnson & Johnson, in testing a simulated version of a blockchain platform designed to track drugs across the supply chain.

Over the past 5 years, a few promising candidate drugs designed to ward off the effects of radiation exposure have begun to undergo animal, and even human, testing.

Scientists have developed a three - in - one blood test that could transform treatment of advanced prostate cancer through use of precision drugs designed to target mutations in the BRCA genes.

In one set of tests designed to quantify how much the rats desired each drug, they could get another infusion only by making ever - greater numbers of lever presses.

Virtual testing gets us one step closer to abandoning the lucky - strike method and consciously designing the drugs we need.

Dr Ishwar Singh, a specialist in novel drug design and development from the University of Lincoln's School of Pharmacy, said: «Translating our success with these simplified synthetic versions from test tubes to real cases is a quantum jump in the development of new antibiotics, and brings us closer to realising the therapeutic potential of simplified teixobactins.

Working with the pharma and biotech industries, Poirier focuses on both performing the genetic tests in his laboratory and designing the clinical drug trials.

For treatment, that knowledge could make a huge impact: not only should researchers be better about testing potential migraine drugs on men and women separately, Maleki says, but they may be able to design new treatments based on these brain differences — giving both sexes a better chance at relief.

The researchers caution that the reliable detection of small to moderate risks and benefits of drug therapies requires cogent data from large - scale randomized trials designed a priori to test the hypothesis.

When scientists gave mice an oral drug called LM11A - 31 (designed to prevent neural degeneration in Alzheimer's patients) just hours after a complete spinal cord injury, it limited the death of cells that protect nerve fibers, allowing test rodents to retain their ability to walk and swim.

The researchers allowed rats to self - administer meth using a paradigm designed to examine individual differences in the rats» drug - taking behavior, then tested the effects of oxytocin on their motivation to acquire the drug.

Professor Alvaro Mata, from Queen Mary's School of Engineering and Materials Science, said: «The technique opens the possibility to design and create biological scenarios like complex and specific cell environments, which can be used in different fields such as tissue engineering by creating constructs that resemble tissues or in vitro models that can be used to test drugs in a more efficient manner.»

In February, for example, the Food and Drug Administration approved MammaPrint, a test designed to help breast cancer patients.

«The mouse work is promising enough to adapt these technologies for real time analysis of patient materials so that clinical trials can be designed to test this new diagnostic and drug selection approach,» he said.

The findings suggest that clinical trials should be designed to test the drug in diabetic patients.

There are many stages in the drug discovery / development process from target identification, assay design, and screening through to compound optimization, pharmacology, and testing in animal models.

Yet much of the evidence cited by smart drug enthusiasts comes from animal experiments which can, by virtue of their design, test only a drug's effect on learning, not recall.

At the Interscience Conference on Antimicrobial Agents and Chemotherapy in Chicago, Illinois, this weekend, researchers reported preliminary results from tests of a novel treatment in 15 HIV - infected people designed to free them from the need to take antiretroviral drugs.

Vaquer designed experiments to test the behavior of drugs in microgravity during his spare time, while he was working in the lab of pharmacologist Rafael de la Torre at IMIM, focusing on a family of membrane proteins called ABC transporters.

Importantly, these studies provide the foundation for the in vivo characterization of the mechanisms that contribute to drug - induced cognitive impairments that will greatly facilitate the design and testing of therapeutic interventions to ameliorate excessive impulsivity that sabotages attempts at prolonged drug abstinence.

Although, Hedrick and Linden target different cell types, innovations by both groups could encourage clinical tests of drugs designed to switch on a patient's immune cells by eradicating secondary lung malignancies.

«Working closely alongside the drug development teams at Merck offers an outstanding opportunity to create new benchmarks for the R&D process, with the ultimate goal of optimizing drug candidates earlier by testing them in Organ - Chips that mirror what happens in the patients whom the medicines are designed to treat and cure,» said Geraldine A. Hamilton, Ph.D., President and Chief Scientific Officer of Emulate.

These chips could also be used to evaluate antibody drugs and other immunotherapies, which are difficult to test thoroughly in animals because the treatments are only designed to interact with the human immune system.

The specific drugs designed by WAVE have been tested in cells in a petri dish, where they successfully lowered the mutant protein whilst leaving the normal version relatively untouched.

The trial was designed to test the safety of the drug and whether or not the drug could do what it was designed to do - reduce the production of the huntingtin protein.

And this «futility trial» design - the first of its kind in HD - is likely to be a really useful way of choosing the most promising drugs to test in large studies.

We're now testing new drugs designed to target and kill the cancer stem cells.

Our platform is designed to emulate human biology more accurately than current cell culture or animal models, and we are currently working with a diverse group of partners to test the way drugs, foods, and chemicals affect human health.

A research scientist becomes the world's first pregnant man in order to test a drug he and a colleague have designed for expectant women.

The tests are not designed to place a criminal label on an offender but to serve as an intervention to help put a stop to teens who have decided to use drugs, The substances that will be detected in the tests include Meth, cocaine, marijuana, oxycodone, ecstasy and pharmaceutical - strength steroids.

except that it shall not be a violation of this Act for a covered entity to adopt or administer reasonable policies or procedures, including but not limited to drug testing, designed to ensure that an individual described in paragraph (1) or (2) is no longer engaging in the illegal use of drugs; however, nothing in this section shall be construed to encourage, prohibit, restrict, or authorize the conducting of testing for the illegal use of drugs.

(3) is erroneously regarded as engaging in such use, but is not engaging in such use; except that it shall not be a violation of this Act for a covered entity to adopt or administer reasonable policies or procedures, including but not limited to drug testing, designed to ensure that an individual described in paragraph (1) or (2) is no longer engaging in the illegal use of drugs.

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Drugs are tested by the people who manufacture them, in poorly designed trials, on hopelessly small numbers of weird, unrepresentative patients, and analysed using techniques which are flawed by design, in such a way that they exaggerate the benefits of treatments.

We don't yet have good design tools to create drugs or enzymes that bind to these new proteins, but we do have some computer software that can test potential drugs's fit with new proteins.

Where a drug and alcohol testing policy is required to maintain a safe workplace, employers should take a proactive approach to implementing and carrying out the testing, and design policies so that they avoid or eliminate potential discrimination.

Laws regarding obtaining commercial drivers» licenses, maintenance and repair of the trucks, safe operation of trucks, inspection of trucks and loads, proper loading, unloading, and securing of heavy loads, transportation of hazardous materials, driver conduct, alcohol and drug testing programs, training and instruction for truckers, have been passed by the federal government, and individual state governments; all these laws and regulations have been designed to make trucks safer and reduce truck accidents.

Furthermore, we will help you design a drug testing program that complies with state laws or federal regulations, as applicable to your organization.

It is legal to drug test your employees, and prospective hires, but like any background screening program, it must be carefully designed to comply with regulations.

It features ready - to - use packages, designed to industry best practices, to accelerate your candidate background checking and drug testing processes.

The new platform is designed to help employers control costs and reduce turnaround time in receiving drug test and background search results.

Gathered requirements, designed, developed, tested and trained users on new functionality to ready to inject (RTI) drugs.

Aurico's nomination stems from the design and development of WebACE ™, their cloud based proprietary platform that assists recruiters and hiring managers with the ordering, retrieval, and reporting of background screening and drug testing products and services.

Professional Duties & Responsibilities Biomedical and biotechnology engineer with background in design of biomaterials, biosensors, drug delivery devices, microfrabrication, and tissue engineering Working knowledge of direct cell writing and rapid prototyping Experience fabricating nanocomposite hydrogel scaffolds Proficient in material analysis, mechanical, biochemical, and morphological testing of synthetic and biological materials Extensive experience in bio-imaging processes and procedures Specialized in mammalian, microbial, and viral cell culture Working knowledge of lab techniques and instruments including electrophoresis, chromatography, microscopy, spectroscopy, PCR, Flow cytometery, protein assay, DNA isolation techniques, polymer synthesis and characterization, and synthetic fiber production Developed strong knowledge of FDA, GLP, GMP, GCP, and GDP regulatory requirements Created biocompatible photocurable hydrogels for cell immobilization Formulated cell friendly prepolymer formulation Performed surface modification of nano - particle fillers to enhance their biocompatibility Evaluated cell and biomaterial interaction, cell growth, and proliferation Designed bench - top experiments and protocols to simulate in vivo situations Designed hydrogel based microfluidic prototypes for cell entrapment and cell culture utilizing computer - aided robotic dispenser Determined various mechanical, morphological, and transport properties of photocured hydrogels using Instron, FTIR, EDX, X-ray diffraction, DSC, TGA, and DMA Assessed biocompatibility of hydrogels and physiology of entrapped cells Evaluated intracellular and extracellular reactions of entrapped cells on spatial and temporal scales using optical, confocal, fluorescence, atomic force, and scanning electron microscopies Designed various biochemical assays Developed thermosensitive PET membranes for transdermal drug delivery application using Gamma radiation induced graft co-polymerization of N - isopropyl acylamide and Acrylic acid Characterized grafted co-polymer using various polymer characterization techniques Manipulated lower critical solution temperature of grafted thermosensitive co-polymer Loaded antibiotic on grafted co-polymer and determined drug release profile with temperature Determined biomechanical and biochemical properties of biological gels isolated from marine organisms Analyzed morphological and mechanical properties of metal coated yarns using SEM and Instron Performed analytical work on pharmaceutical formulations using gas and high performance liquid chromatography Performed market research and analysis for medical textile company Developed and implement comprehensive marketing and sales campaign

Professional Experience Indian Health Services (Winnebago, NE) 04/2011 — Present Registered Nurse • RN for medical / surgical floor, drug dependency unit, wound / infusion clinic, immunization clinic, ER, and outpatient clinic • Oversee patient intake, triage, and discharge in a timely and organized manner • Provide exceptional patient care and chart progress in accordance with physician designed treatment plans • Administer medications, treat wounds, perform tests, and interpret lab results • Maintain working knowledge of accepted standards of care and emerging medical technology • Train junior nurses and administrative personnel in industry best practices ensuring orderly operations • Responsible for patient and family education in healthy lifestyles and ongoing disease management

This analysis at The Conversation by Australian National University Public Policy Professor Peter Whiteford says it is worrying that the budget papers do not identify the costs of the drug testing proposal nor the expected savings, concluding that the proposal is symbolic, rather than designed to have a positive impact.

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