Sentences with phrase «tested on animal models»

Not exact matches

It is customary and even ethically mandatory that experimentation that carries with it a substantial degree of risk to human subjects first be tested in an animal laboratory or, at the very least, on a computer model.

New experimental models based on three - dimensional reconstructions of human skin are helping to reduce chemical testing on live animals, but can not yet replace animals altogether

The study is one of the first to test if the «landscape of fear» model, a scientific theory that has been used to explain how animals move and interact with the environment based on their fear of being attacked by their predators, is applicable to large open marine systems involving wide - ranging species, like sharks and turtles.

«Most pain medications that have been tested in the past decade have failed in phase II human trials despite performing well in animal models,» notes Clifford Woolf, MD, PhD, director of Boston Children's F.M. Kirby Neurobiology Center and a co-senior investigator on the study with Michael Costigan, PhD.

The researchers, who evaluated the BSCB in test animals at seven and 30 days after stroke modeling, found that ischemic stroke damaged the gray and white matter in the cervical spinal cord on both sides of the spinal column, based on analysis of electron microscope images.

The researchers now plan to test this type of insulin in other animal models and are also working on tweaking the chemical composition of the insulin to make it even more responsive to blood - glucose levels.

«Our work and that of our colleagues on stress and CRF have been mechanistically implicated in Alzheimer's disease, but agents that impact CRF signaling have not been carefully tested for therapeutic efficacy or long - term safety in animal models,» said the study's principal investigator and corresponding author Robert Rissman, PhD, assistant professor in the Department of Neurosciences and Biomarker Core Director for the Alzheimer's Disease Cooperative Study (ADCS).

The most promising active ingredients were then tested on model animals: ursolic acid, a waxy natural chemical found in apple peels and rosemary; curcumin, the bright yellow plant compound in turmeric; and resveratrol, a natural compound common to red grapes or berries.

The first genetic clues for slowing aging emerged from animal models in which the effect of individual genes on average life spans could be tested.

According to the authors of the study, in future researches it will be necessary to know about the action mechanism of the new products - highly selective and with low cell toxicity on in vitro tests - and broaden preclinical studies with laboratory animal models.

When he was still an experimentalist in the early 1970s, he began to explore mathematical models of animal behavior in tests that focused on the way animals make choices.

Assistant Professor Arindam Basu from NTU's School of Electrical and Electronic Engineering said the research team have tested the chip on data recorded from animal models, which showed that it could decode the brain's signal to the hand and fingers with 95 per cent accuracy.

Although further refinement and testing is needed, Dr. Burgess said the new techniques have the potential to speed the production of many different types of transgenic animal models that will shed new light on human development and disease.

NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesDA and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from Neural Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals models.

Based on their expertise in immunology and pathology and the available infection models, vaccines against most relevant viral and bacterial animal infections can be tested.

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They will then test in vivo (in animals) their combination of drugs on the best mouse model available to study lipofuscin - mediated retinal degeneration.

The fruit fly is the ideal animal model because the molecular structure of its ear is more similar to humans than that of rats or guinea pigs, meaning tests on fruit flies yield more accurate results.

Over the last few years, scientists have been able to recreate accurate models of human organs by embedding living tissue onto chips, allowing them to study the effects of drugs and diseases without testing on animals or humans.

The PD model animals did prove to exhibit substantial water maze deficits, both in time to locate the hidden platform and in time spent in the target quadrant on the probe test.

Through «heart - on - a-chip» technology — modeling a human heart on an engineered chip and measuring the effects of compound exposure using microelectrodes — Lawrence Livermore researchers hope to ensure potentially lifesaving new drugs are safe and effective while reducing the need for human and animal testing.

To test this effect on disease, the researchers used a mouse model of MS and treated the animals with a drug that inhibits SIRT1.

The center will develop techniques to test the drugs in cell culture and animal models, to validate their effects on a certain disease.

Through «heart - on - a-chip» technology — modeling a human heart on an engineered chip and measuring the effects of compound exposure on functions of heart tissue using microelectrodes — Lawrence Livermore National Laboratory (LLNL) researchers hope to decrease the time needed for new drug trials and ensure potentially lifesaving drugs are safe and effective while reducing the need for human and animal testing.

Once a scientist identifies a drug that can be repurposed using the database, the drug's potential effect must be then tested on a new disease, both in animal models and human clinical trials.

The project has focussed on developing new animal models which use brain recording and behavioural tests to identify innovative and effective drugs for schizophrenia.

Computer models can be used for some research, but those results later must be verified by tests on animals and humans.

Multiple studies show that the catechin compounds found in green tea can have various protecting effects on neurons in test tubes and animals models, potentially lowering the risk of disease like Alzheimer's and Parkinson's.

Multiple studies show that the catechin compounds in green tea can have various protective effects on neurons in test tubes and animal models, potentially lowering the risk of Alzheimer's and Parkinson's (28, 29, 30).

Thanks to its diverse models and foundation in 40 different shades, people have gotten excited about how socially conscious Rihanna's makeup brand, Fenty Beauty, is — but that also begged the question of whether Fenty Beauty products are tested on animals.

Prior to using the One Health model, only 8 percent of cancer drugs tested on animals with artificial disease worked on people.

Testing compounds and pharmacological agents following strict protocols and rigorous study measures on live animal models.