Sentences with phrase «tested tumor tissue»

A team of researchers in Baltimore tested tumor tissue and healthy tissue from 815 patients who had various cancers.

Not exact matches

As new oncogenic driver genes are identified, the testing process becomes less efficient because more genes need to be analyzed in limited amounts of tumor tissue.

In 2002 scientists showed that cytomegalovirus, or CMV, was active in the brain tumors but not the surrounding healthy tissue of all 27 patients they tested who had glioblastoma multiforme.

«The ability to test our ideas in tumor tissues removed from patients underscores the unique and multi-disciplinary nature of our Prostate Cancer Program, one of only eight Prostate Cancer Programs of Excellence in National Cancer Institute Designated Centers,» said Dr. Knudsen.

Doctors already test breast tumors for Ki67 levels, which can inform decisions about treatment, but this is the first time scientists have been able to link Ki67 to precancerous tissue and use it as a predictive tool.

But it has been harder to test whether cancer stem cells fuel the growth of tumors in other tissues.

To test this idea, the researchers utilized two mouse models of human breast cancer metastasis and found dormant disseminated tumor cells residing upon the membrane microvasculature of lung, bone marrow and brain tissue.

In addition, masitinib strongly impaired tumor growth in all of the DLBCL patient - derived tissues that the team tested.

«Being able to safely take tissue samples will also allow us to test for specific tumor sub-types and better decide the most appropriate treatment for each individual patient,» added Dr Booton.

Rather than simply identifying a cancer by location or tissue type, researchers now use advanced molecular profiling tests to characterize tumors, the proteins they express and the novel mutations they develop — known as neoantigens.

Various genetic testing methods were used to examine lung tumors, uninvolved lung tissue and normal - appearing airways located varying distances from the tumors.

The technique is currently being tested in a number of clinical applications, including imaging breast tumors, detecting skin cancer, and tracking blood oxygenation in tissues.

Importantly, without any prior knowledge from the analysis of tumor tissue, 76 % of «actionable» mutations (genetic changes that can be matched to an approved targeted therapy or one being tested in clinical trials) detected in tissue were also detected in blood.

«In our practice, we recommend that all patients with baseline EGFR T790M identified in their lung tumor tissue be referred to clinical genetics to discuss EGFR T790M germline testing.

This repair, which was tested in mice and tissue cultures, slowed cancerous tumor growth.

The new iPS cells passed the standard tests for pluripotency: They formed tumors called teratomas when injected into immunocompromised mice, and they could differentiate into cells from the three main tissue types in the body, including neurons, muscle and gut epithelium.

The researchers tested whether stromal tumor infiltrating lymphocytes (TILs) and other immune cells might predict responses to therapy in a set of 30 HER2 - positive breast cancer tissues treated with TCHP (26 patients) or with TCH without pertuzumab (4 patients).

PHOTO: Harbour LaboratoryUsing very small amounts of tumor tissue collected by a needle biopsy, doctors can conduct gene expression profile testing to determine the likelihood that an ocular melanoma tumor will spread beyond the eye.

For AQUA analysis, 2 pairs of slides (containing two cores from different areas of each matching primary and metastatic tumor per patient) or test arrays of cores from FFPE placental tissue and MEL624 cells not overexpressing or overexpressing PD - L1 were concomitantly stained.

Materials scientists, for example, can help compare the material properties of normal and tumor tissue and then make matrices that exhibit their properties for biologists to run tests on.

Inclusion Criteria: • Availability of tumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion critumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion criTumor type specific exclusion criteria

Laser Light Test Reveals Spreading Cancer Cancer imaging and breast cancer experts used advanced microscopes equipped with tissue - penetrating laser light to develop a promising new way to accurately analyze the distinctive patterns of ultra-thin collagen fibers in breast tumor tissue samples and to help tell if the cancer has spread.

A new cancer - seeking compound that can trace a pancreatic tumor's outline with exceptional clarity, then attack cancer cells while leaving healthy tissues alone, is undergoing tests at the Roswell Park Comprehensive Cancer Center's Photodynamic Therapy Center.

Also utilizing imaging, PIs Joseph Paydarfar, MD, Ryan Halter, PhD, and David Pastel, MD, will test their solution to the problem that, in patients with head and neck cancer, significant tissue deformation occurs during laryngoscopy, rendering pre-operative images unusable for assessing tumor extent and location of critical structures.

And even if we do, how much do we have to eat to arrive at these test tube concentrations where it counts — in breast tissue itself, where a tumor may be evolving?

With the funding, the organization hopes to implement: clinical trials to test new innovative therapies to help save dogs and alleviate dog suffering now, prevention studies related to genetics and canine genome, incorporating lifetime risk, funding of a tumor tissue bank, and establishment of an endowment to guarantee continued research efforts.

Possible diagnostic tests will include blood work, urinalysis, tissue biopsies or fine - needle aspirations, bone marrow aspirations, lymph node aspirations and possible X-rays, depending on the location of the tumor.

Treatment of mammary tumors involves surgical excision of all abnormal tissue with submission of the tissue for histopathology (testing to determine tissue health and presence of malignancy).

Tissue reaction / allergy / foreign body: he could have a splinter or something that got walled off Insect bite that caused a granuloma Lipoma: if it is movable and small and soft (but not necessarily 100 %) it could be a fatty benign tumor Other neoplasia (I could go on and on but Dexter younger, so it is less likely) MCT Etc. ect... the tests need to be done to determine the cause