Sentences with phrase «testing drug candidates»

Furthermore, the cells offer a renewable, long - lasting model system for testing drug candidates or gene modifications that may offer new treatments, personalized to individual patients.

Future trials might show improved results from testing the drug candidate in even younger patients or over much longer periods of time, the scientists say.

«The iPS cells will provide insights into Huntington's disease, helping us to develop new therapies and test drug candidates,» said Dr. Finkbeiner, who is also a professor of neurology and physiology at the University of California, San Francisco, with which Gladstone is affiliated.

Not exact matches

In December, Tehrani signed a deal with GlaxoSmithKline that will allow the pharmaceutical giant to test at least four of its drug candidates on a Zymeworks - designed platform, which combines a computer simulation with a way of engineering protein molecules and allows products to be refined before they move to expensive clinical trials.

Prior to an offer letter each candidate goes through an extensive background check and drug testing.

This sad action maintains a 20 - year record of that Court's refusal to accept any case brought to it by a minor party or an independent candidate (not counting a 1997 case in which a Georgia Libertarian candidate challenged Georgia's law requiring candidates for state office to take a drug test).

He says that using a liquid biopsy test that was developed and now offered at Dana - Farber Cancer Institute, he was able to determine that the patient did indeed have the mutation, making her a good candidate for drugs that target it.

Over the past 5 years, a few promising candidate drugs designed to ward off the effects of radiation exposure have begun to undergo animal, and even human, testing.

The three remaining drug candidates that target amyloid - β are currently being tested in people with Alzheimer's, as well as in individuals who have a high risk of developing the disease but who have not yet developed symptoms.

This portion of the pharmaceutical process, in which drug candidates are identified and tested, now employs many of the latest findings in genomics and proteomics.

For now, Rashid's group has a list of candidate therapeutic drugs that they'll test in their new liver disease models, something that may still prove useful to patients.

Mao is recruiting patients for clinical trials to test two candidate drugs.

Instead of systematically testing the effects of known compounds — the pharmaceutical industry's basic model for more than a century — scientists can now investigate backward, combing through genomic data to find links between specific genotypes and diseases and then screening drug data to identify therapeutic candidates.

Scientists characterize the advance as a game changer that could dramatically accelerate the testing of new drug candidates.

Exploiting the same pre-clinical model used for their studies, the researchers are testing the efficacy of this kind of drug candidates against cancer stem cells, and the possibility of identifying combination regimens with standard chemotherapies with minimized toxic effects, with the perspective of their possible application for the treatment of human breast cancer.

Several research institutions and companies have vaccine and drug candidates nearly ready to test, but until now a mouse model — a critical stage in preclinical testing — has not been available.

The mice described in the current report were developed for testing of drug and vaccine candidates and may not be good models for human transmission, said Weaver.

His team looked at an experimental drug called PTC124, which the firefly luciferase assay had identified as a promising candidate for treating stop - sign forms of cystic fibrosis and which is now being tested in clinical trials.

Mead believes ALS is ripe for AI and machine - learning because of the rapid expansion in genetic information about the condition and the fact there are good test - tube and animal models to evaluate drug candidates.

They then tested eight of the most promising candidate drugs against cells grown from other human vestibular schwannomas.

Meanwhile, HUB is building a biobank, financed by Dutch health insurers, containing organoids from all 1500 Dutch CF patients for testing both existing drugs and new candidates.

Knowing of America's desperate search for new antimalarial drugs (by then, the U.S. government and Winthrop scientists had screened roughly 14,000 candidate compounds), French military doctors shipped samples back to the States for further testing.

Worse, many promising drug candidates fail in phase II clinical trials when their efficacy is put to the test.

The automated method could also be used to easily test the effects on brain cells of a range of molecules and see which might be drug candidates.

The new blood test will initially be used to identify those people with mild cognitive impairment who are likely to get Alzheimer's disease and so might be good candidates for clinical trials to find drugs that halt disease progression.

While the goal of precision medicine is to identify drugs that selectively affect disease - causing biomolecules, the process has typically involved time - consuming and expensive high - throughput screens to test millions of potential drug candidates to identify those few that affect the target of interest.

«The cost to run high throughput testing for antiepileptic drug candidates would cost a fraction in time and money compared to the experiments available today,» said Dawson - Scully.

This has led to a demand for people who can understand data collection techniques and analyze vast amounts of data, categorize the data sets, develop models to test hypotheses that can then be used to develop drugs, and test potential candidates in animals.

CADD, or «rational drug discovery,» helps make it possible to select a more manageable number of candidates that can then be tested experimentally.

Tropsha now develops models to test the relation between structure and activity of drug candidates and studies protein folding and the effects of mutations on protein structure.

2002 - 2003 — Vertex finds promising drug candidates among 200,000 compounds tested, including VX - 770 (doorman drug) and VX - 809 (corrector drug).

According to the current schedule, it is envisaged that the drug candidate will be tested on humans as part of a phase 1 study in November 2017.

«Future research will focus on optimizing the candidate therapies discovered by our team in this study as well as developing biomarkers that can be used to test the efficacy of other potentially promising drugs,» says Dr. Rothstein

UNITY has completed a rigorous screening and preclinical testing process of candidate drugs, discovered in this study, and is launching a new clinical trial to assess its first drug, for patients with osteoarthritis of the knee this year.

Later phases of the project will confirm efficacy against live Ebola virus, determine how the drug candidates block the viral machinery and develop additional tests to identify drug candidates that will inhibit not only Ebola virus, but also the related Marburg virus.

To help Gladstone discoveries successfully cross through the valley of death, the Hellman Family Foundation Alzheimer's Research Program subsidizes the myriad of early - stage, de-risking tests necessary to make a drug candidate more attractive to pharmaceutical - industry partners, such as tests that reveal at what concentrations a drug stops being therapeutic and instead becomes toxic.

El - Khodor, B. F.; Edgar, N.; Chen, A.; Winberg, M. L.; Joyce, C.; Brunner, D.; Suarez - Farinas, M.; Heyes, M. P. Identification of a battery of tests for drug candidate evaluation in the SMNDelta7 neonate model of spinal muscular atrophy.

«Working closely alongside the drug development teams at Merck offers an outstanding opportunity to create new benchmarks for the R&D process, with the ultimate goal of optimizing drug candidates earlier by testing them in Organ - Chips that mirror what happens in the patients whom the medicines are designed to treat and cure,» said Geraldine A. Hamilton, Ph.D., President and Chief Scientific Officer of Emulate.

The early intervention strategy is most frequently used for drug testing in AD because drug candidates assayed in AD transgenic mice at the stage when pathology is already present are generally less effective [27 — 30].

Clinical Trials Center This center has focused capabilities to test new candidate drugs and vaccines to prevent and treat infectious diseases.

Their hope is that drug candidates that get as far as animal testing and clinical trials will then be more likely to be safe and effective.

And indeed, the safety of both candidate drugs is due to be tested in people this fall.

Partnership to adopt Organ - Chips to provide human - relevant data in drug discovery and development aiming to reduce animal testing, and to implement personalized safety testing of new drug candidates

Excitingly, because stem cells can produce such large numbers of neurons, we can even test for and identify new drug candidates using patient specific neurons.

Current topics include vaccine efficacy testing and immune correlates of TB, AMA1 as a malaria blood stage vaccine candidate in clinical development and development of new drugs active against malaria hypnozoites.

of employers in the U.S. drug test job applicants, keeping companies from hiring the best possible candidates.

Unfortunately, those same traits make them great candidates for puppy mills and drug testing labs.

We are drug free workplace, all candidates must submit a pre-employment background check and drug test

A background check and pre-employment drug test will be required of the successful candidate.

A history of alcohol abuse, driving violations, failed drug tests, etc. make certain truck driver candidates too dangerous for the job for which they have applied.