Sentences with phrase «testing in rodents»

Many new approaches are still in testing in rodents.

«Stem cell strategy for boosting testosterone levels tested in rodents.»

(B) Pre-clinical in vivo functional testing in rodent and non-human primate models of HD (in collaboration with Dr. Hantraye & Dr R Aron - Badin CEA - MIRCen and Dr. Dunnett, Cardiff University, UK).

Not exact matches

Rats are not people, of course, and test results in rodents are never perfectly translated in people (if at all).

The study, just published in Science, showed that the creation of what the researchers are calling microtumors can help predict drug effectiveness in cancer patients better than the current standard method of testing the drugs on rodents.

In rodent tests, these gametes were successfully fertilized and pups were born.

When the EPA wants to set a pesticide standard, they have companies test the pesticide in rodents and measure what's called the no observed effect level — the NOEL — which becomes the threshold.

Despite promising results from past studies in rodents and nonhuman primates, testing the antisense strategy in people carried big unknowns.

But in the mid -»90s, after the passage of the Food Quality Protection Act, the pesticide industry found a way around that: Instead of testing pesticides in rodents, they began testing them in humans — usually very poor people.

The study wasn't about designing a new way of testing animal behavior, either; the same test has been used in rodents.

As a first step, his team is testing whether it's possible to stop or slow tau - driven neuron loss and inflammation by lowering ApoE in the early life of laboratory rodents.

To see which are involved in heart - cell division, Giacca's team tested 875 human microRNAs in cultured rodent heart muscle.

In one test, a colleague injected rats with the dinosaur fossil extract; the rodents produced antibodies that responded to turkey and rabbit hemoglobins.

UCI's Charles Limoli and colleagues found that exposure to highly energetic charged particles — much like those found in the galactic cosmic rays that will bombard astronauts during extended spaceflights — causes significant long - term brain damage in test rodents, resulting in cognitive impairments and dementia.

New Scientist was unable to reach the Lisbon team members, but Jean Peduzzi - Nelson, a stem cell researcher at Wayne State University in Detroit, Michigan, who advised the team on their surgical technique — she had previously tested it on rodents — claims the clinic has given the therapy to about 140 people in total.

The endangered bushy - tailed rodents (Sciurus vulgaris) have tested positive for leprosy - causing bacteria in several locations around the British Isles, researchers report November 11 in Science.

Elderly rodents that received human umbilical cord blood improved significantly in memory tests

After testing StimDust on the benchtop, the research team implanted it in a live rodent to test it in a realistic environment.

Afterward, in tests to see if the mice displayed the rodent equivalent of anxiety and depression symptoms, they found about 40 percent showed high levels of behaviors that included a preference for a dark compartment over a brightly lit one, or a loss of interest in sugar water.

The next stage will be to test xenon in live rodents exposed to similar conditions.

Charged with finding a new remedy for malaria, scientists working for Mao Tse - tung and Chou En - lai decided to test Ge Hang's ancient wormwood recipe in mice infected with a malarial strain that is lethal in rodents.

When Sicai and his colleague Jie Zhang, PhD, tested the toxin in rodents in the lab, it had little or no effect.

The next step is to test whether reversing the oxytocin receptor deficits in rodents» brains relieves symptoms.

When scientists gave mice an oral drug called LM11A - 31 (designed to prevent neural degeneration in Alzheimer's patients) just hours after a complete spinal cord injury, it limited the death of cells that protect nerve fibers, allowing test rodents to retain their ability to walk and swim.

The big rodents spotted hundreds of TB - positive sputum samples that a standard microscope test missed on first pass, researchers report in the December American Journal of Tropical Medicine and Hygiene.

In a hotly debated move, the U.S. Environmental Protection Agency (EPA) has selected this unassuming rodent as the primary test animal for a vastly complex and comprehensive new chemical - evaluation program.

To test the long - term spatial memory of mice, the scientists trained the rodents to spot a new object placed in a controlled environment where two objects of similar shape and volume stand.

The researchers also tested whether CRF production in the VTA was linked to escalation of nicotine intake in rodents that had withdrawn from the drug and then had nicotine access restored.

In laboratory tests using rodents, White and his colleagues found that while morphine lost its pain - relieving effectiveness three weeks after nerve injury, a combination therapy of morphine and carbamazepine — used to prevent epileptic seizures — could effectively reverse this loss of drug action.

Using a strain of malaria that primarily infects rodents, Derbyshire and Jon Clardy of Harvard Medical School tested 1,358 compounds for their ability to keep parasites in the liver in check, both in test tubes and in mice.

With the cooperation of local governments, researchers sampled and tested 19,192 bats, rodents, non-human primates, and humans in areas where the risk of animal - to - human transmission is greatest, including sites of deforestation, ecotourism, and animal sanctuaries.

Since the researchers used rodents for the pain test, they can't entirely rule out the possibility of blenny venom causing pain in fish, but it seems plausible that the neuropeptide and opioid components may cause a sudden drop in blood pressure, most likely leaving the blenny's attacker disorientated and unable to give chase.

The device was tested in a guinea pig, with the electrodes attached to both sides of the rodent's cochlear hair cell membranes.

However, stimulation of targets in the lateral hypothalamus in rodents during learning resulted in improved performance on tests of subsequent memory.11

Other, better tests of impulsivity that evaluate premature decision - making can be applied in rodents and humans.

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«Laboratory rodent diets contain toxic levels of environmental contaminants: implications for regulatory tests» by Robin Mesnage et al. published in PLOS ONE on Thursday 2 July 2015.

To carry out pre-clinical testing of stem cell - derived mesDA and striatal GABAergic progenitors in rodent models of PD and HD with the goal to generate efficient and safe candidate cells for clinical use;

In order to test this hypothesis, the scientists induced psoriasis - like symptoms in the rodents» earIn order to test this hypothesis, the scientists induced psoriasis - like symptoms in the rodents» earin the rodents» ears.

In the second half of the study, we will test whether our gene therapy vector is effective at halting the progression of an optic neuropathy in rodentIn the second half of the study, we will test whether our gene therapy vector is effective at halting the progression of an optic neuropathy in rodentin rodents.

We will leverage state - of - the - art bioinformatic and biological approaches for investigating how these factors interact in combination to regulate axon growth during RGC development and test the potential of such factors for regenerating RGC axons in a rodent model of optic nerve injury.

A consortium of researchers from North Carolina State University, Texas A&M, USDA, CSIRO (in Australia), and Island Conservation are in a proof - of - concept phase of developing and testing genetic systems of this sort in the laboratory to precisely eliminate invasive rodents from sensitive ecosystems.

In mouse models in which the endogenous Smn1 gene has been knocked out and human versions of SMN2 have been swapped in, the Isis therapy — a so - called «antisense oligonucleotide» — delivered to the mouse central nervous system (CNS) increased the expression of full - length SMN protein in motor neurons, improved muscle strength in behavioral tests and extended the rodents» median lifespan from 16 days to 26 daysIn mouse models in which the endogenous Smn1 gene has been knocked out and human versions of SMN2 have been swapped in, the Isis therapy — a so - called «antisense oligonucleotide» — delivered to the mouse central nervous system (CNS) increased the expression of full - length SMN protein in motor neurons, improved muscle strength in behavioral tests and extended the rodents» median lifespan from 16 days to 26 daysin which the endogenous Smn1 gene has been knocked out and human versions of SMN2 have been swapped in, the Isis therapy — a so - called «antisense oligonucleotide» — delivered to the mouse central nervous system (CNS) increased the expression of full - length SMN protein in motor neurons, improved muscle strength in behavioral tests and extended the rodents» median lifespan from 16 days to 26 daysin, the Isis therapy — a so - called «antisense oligonucleotide» — delivered to the mouse central nervous system (CNS) increased the expression of full - length SMN protein in motor neurons, improved muscle strength in behavioral tests and extended the rodents» median lifespan from 16 days to 26 daysin motor neurons, improved muscle strength in behavioral tests and extended the rodents» median lifespan from 16 days to 26 daysin behavioral tests and extended the rodents» median lifespan from 16 days to 26 days3.

While the United States Department of Agriculture (USDA) keeps track of many species used for testing — birds, dogs, cats, rabbits and even the rodent guinea pig — nobody in the United States keeps a comprehensive list of all the mice or rats used in research.

In large quantities, acrylamide is a known cancer - causing chemical according to results from tests with rodents, Lichtenfeld explained.

Tests carried out by Princeton researchers on rodents showed a very significant difference between the addition of sugar or hfcs in the diet.

So far, I've reviewed the basics on assessing studies and the importance of differentiating essential oils» mechanisms in humans versus in petri dishes or rodents.6 I've also discussed why it is imperative in experiments to use quality, uncontaminated essential oils that are not polluted with plasticizers to provide valid results.6 - 9 Another pitfall I highlighted with in vitro (petri dish) studies included the use of testing trays that contain phthalates and endocrine disruptors which can escape into the experiment along with the essential oils.

Once HSMO has vaccinated, tested for feline leukemia, spayed / neutered and notched the ear tip, the cats are ready to provide service in exchange for daily food and water in addition to the rodents they catch, protection from the elements and long - term vet care.

The experiments proving the merits of coconut oil have been done only in humans, rodents and test tubes, which is why we should be very careful with it.

If required, a 90 - day feeding study performed in rodents, according to the OECD Test Guideline, is generally considered sufficient in order to evaluate the health effects of GM feed.