Sentences with phrase «testing novel therapies»

These experiments are innovative because they seek to improve a mouse model based on current knowledge from human disease, while also testing novel therapies that could be of benefit for affected individuals.

Gene and cell therapies have made important medical advances over the past three decade, developing technologies and testing novel therapies in multiple human clinical trials of many diseases.

Therefore, we are investigating mechanisms of network hypersynchronization in AD and testing novel therapies to prevent such deficits.

Furthermore, these mice would provide an excellent model to test novel therapies aimed at preventing metastasis.

His major research interests are human neuroanatomy and neuropathology and the use of animal models to test novel therapies for neurodegenerative diseases including Alzheimer's disease.

This «humanized» mouse is susceptible to human liver infections and responds to human drug treatments, providing a new way to test novel therapies for debilitating human liver diseases and other diseases with liver involvement such as malaria.

But every patient's tumor is different, and clinical trials group all patients together to test a novel therapy — irrespective of the unique characteristics of that patient's tumor, he says.

Not exact matches

Researchers at The University of Texas MD Anderson Cancer Center developed a novel chimeric mouse model to test the combination therapy using immune checkpoint blockades with therapies targeting myeloid - derived suppressor cells (MDSCs).

Our studies have improved our understanding of the basic biology underlying MMA, created a novel animal model for testing interventions and, now, led us to the promise of a new therapy.»

Trapnell and Suzuki were prompted to test the novel macrophage transplantation therapy by studies showing that resident macrophage populations (such as those residing in the lung) can self - maintain without the cells having to regenerate directly from the bone marrow.

Dr. Levine directs the Clinical Cell and Vaccine Production Facility (CVPF), which develops, manufactures, and tests novel cell and gene therapies in clinical trials at Penn and collaborating institutions.

In partnership with the Italian Cystic Fibrosis Research Foundation, we founded a CF animal Core Facility (CFaCore) as a platform for pre-clinical studies and for testing novel antibacterial or anti-inflammatory therapies.

Finally, Pollard wants to close the loop by incorporating code - writing approaches, such as genome editing using CRISPR - based approaches and synthetic biology, which are needed to test and validate hypotheses and could also provide novel therapies.

As demonstrated by the breadth of clinical trial involvement shown above, CCIR members are testing the utility of immune checkpoint blockade in lymphoma (shown by Dr. Allison to be effective against melanoma), genetic engineering in cell therapy (e.g., CD19, CXCR2, TGF - β DNR), and TLR agonists or IL - 2 in vaccine formulations as well as some novel combination therapies, such as the infusion of tumor - reactive lymphocytes from HLA - matched donors who were vaccinated with a lymphoma idiotype.

These therapies are now being tested in various type of cancer and novel combination approaches are being developed at a very fast pace.

Testing a Novel Amyloid - promoting Factor as an Alzheimer's Therapy Daniel Pak, PhD Georgetown University (Washington, DC)

To build upon the encouraging early discoveries, Helmsley renewed and expanded its Crohn's funding for the Institute in 2013 to begin new work with three major aims: 1) continue studies of individual genes to determine how genetic differences between Crohn's patients and healthy individuals contribute to the disease; 2) evaluate promising small molecules in disease - relevant studies and prioritize insights from genetics to help develop novel therapeutics; and 3) begin basic experimentation in animal models with Crohn's disease to provide the data necessary to begin testing new therapies in humans.

He has extensive experience with the development of experimental vaccines for both genital herpes and HIV, and his lab has pioneered novel tests for diagnosing and monitoring therapies for viral infections.

Additionally, this technology could provide a novel research model by which we transplant cells in vivo to study a disease and its progression from the onset, as well as directly test how effective new therapies are.»

Personalized Blood Test Monitors Success Of Cancer Therapies Johns Hopkins Kimmel Cancer Center researchers developed a novel test to measure tumor - derived DNA in the bloodstrTest Monitors Success Of Cancer Therapies Johns Hopkins Kimmel Cancer Center researchers developed a novel test to measure tumor - derived DNA in the bloodstrtest to measure tumor - derived DNA in the bloodstream.

The goal of this Center of Excellence is to better define thrombus development in patients with cancer, test the efficacy of novel therapies, develop new preclinical models, and create and expand biorepositories to provide a valuable resource to researchers across Cleveland Clinic.

Esko is collaborating with Zacharon Pharmaceuticals, a San Diego - based biotechnology company, to develop a commercial diagnostic assay for differentiating forms of MPS from urine and blood samples, a screening test for newborns and a tool for measuring the biochemical response of MPS patients to existing and novel therapies.

The King lab is currently testing these novel cancer therapies in mouse models of metastatic breast and prostate cancer through the use of whole body luminescence imaging.

Many of these strategies are used to then test novel medications (including herbal preparations) or therapies (including electroacupuncture) for drug and alcohol abuse.

In order to demonstrate clinical efficacy and move these novel therapies quickly through the regulatory agencies, accurate and standardized tests need to be employed to measure and monitor these bioengineered constructs.

New treatments are being tested to tackle the crippling difficulties of vertigo, including a clinical trial of prosthetic ear implants and ear gene therapy, with initial work revealing novel aspects of brain anatomy linked to balance which could be used as targets for future treatments.

Informed by the literature on risk factors for IPV maintenance, drawing from the broader psychopathology and psychotherapy literatures, and guided by third wave behavior therapy models, Dr. Lawrence and her students developed a new conceptual model identifying novel processes that underlie the propensity for violent perpetrators to continue engaging in IPV, applied that model to a novel intervention, and then tested the efficacy and effectiveness of that new intervention.