Sentences with phrase «testing vaccine candidates»

This is achieved by testing vaccine candidates in preclinical models.

This will indicate the predictability of testing vaccine candidates in mice, ferrets and pigs before evaluation in NHPs and humans.

The Transnational Access 1 (TNA1) «Cross platform screening and optimization service «and the corresponding Joint Research Activity (JRA1) «Improved optimization and harmonization of cross-vector screening «will combine the expertise of six different partners (IME, SSI, UOXF, iBET, BPRC and UNISI) to provide the unique offer to test vaccine candidates in a comprehensive range of different expression hosts, to identify the optimal production system for further pre-clinical and clinical development.

Not exact matches

And by winter several more vaccine candidates that employ various forms of the virus are slated for human testing, supported by funds from the NIH.

The researchers said it was important to test their candidate vaccines on the Makona strain to ensure that even small differences between the strains didn't impact the effectiveness of the vaccine.

* The NIH says its candidate vaccine — which contains the S139N mutation — did not damage brain tissue in earlier monkey tests.

In 2010, Vaccine Research Center (VRC) scientists and colleagues tested this candidate chikungunya vaccine in non-human prVaccine Research Center (VRC) scientists and colleagues tested this candidate chikungunya vaccine in non-human prvaccine in non-human primates.

Prompted by the recent Zika virus outbreaks in Latin America and some parts of the United States, scientists around the world have been racing to develop candidate vaccines, and already several have been tested in animals.

The study showed that the vaccine being tested elicited more RSV antibodies in young children than a previous RSV vaccine candidate.

«This research team's dedication and previous research on dengue and other arboviruses enabled them to quickly develop this model for Zika virus, an important first step to enable testing of candidate vaccine and therapeutics,» said Stephen Higgs, PhD, the president of the American Society of Tropical Medicine and Hygiene.

Several research institutions and companies have vaccine and drug candidates nearly ready to test, but until now a mouse model — a critical stage in preclinical testing — has not been available.

The mice described in the current report were developed for testing of drug and vaccine candidates and may not be good models for human transmission, said Weaver.

This can inform and accelerate the development of new vaccines, especially important during outbreaks and epidemics when clinical testing of vaccine candidates need to be fast tracked.

In the preclinical study, WRAIR and the Beth Israel Deaconess Medical Center tested two Zika virus vaccine candidates: a DNA vaccine developed at Harvard based on a Zika virus strain isolated in Brazil, and a purified inactivated virus vaccine developed at WRAIR based on a Zika virus strain isolated in Puerto Rico.

Vaccine research will also benefit immediately from the discovery, since scientists can already now test the effectiveness of different vaccine candidates at preventing PfEMP1 from bindinVaccine research will also benefit immediately from the discovery, since scientists can already now test the effectiveness of different vaccine candidates at preventing PfEMP1 from bindinvaccine candidates at preventing PfEMP1 from binding ECPR.

Researchers plan to assess the new modified antigen against other candidates in advanced strep throat vaccine tests in nonhuman primates beginning later this year in Atlanta, Georgia, funded by the National Health and Medical Research Council of Australia.

The most advanced candidate vaccine for malaria has cleared another major hurdle and is now ready for its last and biggest test: a phase III trial of 12,000 to 16,000 children at 11 locations in seven African countries.

«This would allow vaccine candidates to be tested very early and very quickly,» he told VOA, «with rapid turnaround and reporting of results to either advance a vaccine candidate or tell scientists they need to go back and look for other candidates.»

This has yielded three Tuberculosis vaccine candidates undergoing phase IIa testing and three first - in - human trials of novel CMI - inducing adjuvants.

Selected mucosal vaccine candidates will be tested for immunogenicity in mice.

In WP10, iBET will be involved in activities relating to GMP - directed evaluation of vaccine candidate production processes, production scale - up for vaccine candidates, definition of specifications for pilot - scale production, product stability testing and delivery for GLP toxicology studies, as well as the evaluation of development, manufacturing and finishing documentation.

W. Bogers: PhD in immunology and 20 years of experience with NHP models for the preclinical evaluation of HIV vaccine candidates as well as testing antivirals.

In WP10, iBET will be involved in the GMP - directed evaluation of vaccine candidate production processes, production scale - up for vaccine candidates, definition of specifications for pilot - scale production, product stability testing and delivery for GLP toxicology studies, as well as the evaluation of development, manufacturing and finishing documentation.

These proteins can be comparatively tested to identify the most promising vaccine candidates, and to understand how the parasite interacts with the human host and cause disease.

In the new issue of IAVI Report we wrote about how researchers at the AIDS Vaccine 2010 conference in Atlanta discussed the limited window of opportunity for conducting clinical trials to test partially effective HIV prevention strategies, including HIV vaccine candidates and oral or topical antiretroviral pre-exposure prophylaxis (PrEP), in combiVaccine 2010 conference in Atlanta discussed the limited window of opportunity for conducting clinical trials to test partially effective HIV prevention strategies, including HIV vaccine candidates and oral or topical antiretroviral pre-exposure prophylaxis (PrEP), in combivaccine candidates and oral or topical antiretroviral pre-exposure prophylaxis (PrEP), in combination.

In order to efficiently evaluate the newly designed vaccine candidates before testing them in clinical trials there is a need for development of reliable preclinical models.

Dr. Leo Stamatatos, an immunologist in Fred Hutch's Vaccine and Infectious Disease Division, has received funding from the National Institutes of Health to begin manufacturing an HIV vaccine candidate designed to stimulate the production of broadly neutralizing antibodies and to test the experimental vaccine in human clinical Vaccine and Infectious Disease Division, has received funding from the National Institutes of Health to begin manufacturing an HIV vaccine candidate designed to stimulate the production of broadly neutralizing antibodies and to test the experimental vaccine in human clinical vaccine candidate designed to stimulate the production of broadly neutralizing antibodies and to test the experimental vaccine in human clinical vaccine in human clinical trials.

Clinical Trials Center This center has focused capabilities to test new candidate drugs and vaccines to prevent and treat infectious diseases.

The overall objective of PlacID is to validate the non-human primate animal model developed at NIAID - LMIV for the evaluation of the placental malaria vaccine candidates and to assess it as a platform for testing placental malaria vaccine candidates prior to human testing.

As a site proposed for testing vaccines in humans, we requested and were given approval for evaluating different vaccine candidates for safety and effectiveness.

Of the seven tested antigens, one emerged as a strong candidate vaccine: AFF 1.

Research Trials The HVTN also plans to test other HIV vaccine regimens in Southern Africa in a parallel research track using multiple vaccine candidates.

Importantly, this vaccine candidate is a precursor to candidates currently under evaluation for potential testing in West Africa.

The panel discussed progress that's been made including the follow - up to the RV144 Thai prime - boost trial results and in the development of the next generation of vaccine candidates for testing.

Therefore the group: i) characterizes the specificity of these antibody responses to identify relevant targets for a vaccine; ii) developes new approaches to test antibody responses; and iii) adoptes the immunological analysis in preclinical (in rabbits and macaques) and clinical vaccines studies to identify predictive signatures for the development and prioritization of new HIV - 1 vaccine candidates.

A number of private and public health entities have vaccine candidates and antivirals ready to test, but testing has been delayed without a mouse model.

MHRP's expansion of research activities into Mozambique provides scientists the opportunity to test future vaccine candidates against the predominant HIV subtype (C) circulating in this part of the world.

This has yielded three TB vaccine candidates undergoing phase IIa testing and three first - in - human trials of novel CMI - inducing adjuvants.

They have been actively involved in finding immune correlates of protection, implementation of new TB vaccines and testing of vaccine candidates in murine models.

Dr. Jay Nelson stated the first hurdle in testing possible vaccine candidates is determining an appropriate animal model for the Zika virus.

Glenda Gray, executive director of the Wits Health Consortium's perinatal HIV research unit in South Africa, presented data today at the HIV R4P conference in Cape Town indicating that the prime - boost vaccine candidates initially tested in the RV144 trial in Thailand — the only HIV vaccine trial to date to show any efficacy — induced cross-clade immune responses in a Phase I safety trial conducted in South Africa, with immunogenicity similar to or greater than that of the responses induced in Thai volunteers.

Current topics include vaccine efficacy testing and immune correlates of TB, AMA1 as a malaria blood stage vaccine candidate in clinical development and development of new drugs active against malaria hypnozoites.

iBET will be involved in activities related with GMP - directed evaluation of vaccine candidate production processes, production scale - up for vaccine candidates, definition of specifications for pilot - scale production, product stability testing and delivery for GLP toxicology studies, and evaluation of development, manufacturing and finishing documentation.

All of TASC's adoption candidates are tested for FeLV and FIV, microchipped, and started on the deworming and FVRCP vaccine rounds.

The ideal candidate will possess strong animal handling and restraint skills, be able to administer vaccines, draw blood, perform diagnostic testing, and have strong organizational skills and the ability to work independently.