Sentences with phrase «tests than mice»

Not exact matches

In addition, mouse acute oral toxicity testing of the CRTI and PMI proteins showed a lack of toxic effects at dosages thousands of times more than any realistically conceivable dietary exposure from consuming GR2E rice.

Not only would the new method, tested only in mice, be more convenient but also more effective than the flu shot or nasal spray, according to a study at the International Vaccine Institute in Seoul.

These mice performed better than their normal counterparts on learning tests well into old age, and their brains did not exhibit the decline in neurogenesis typically seen in aged mice.

On reanalysing data from the group's past studies, such as on pain sensitivity to hot water, the researchers found that mice tested by men showed lower baseline pain sensitivity than mice tested by women.The work indirectly demonstrates potential effects on nearly any kind of medical research, says Joseph Garner, who studies mouse behavior and well - being at Stanford University in California.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

These effects endured not only throughout the animals» lives but were carried on to the next generation and along the same gender lines: The offspring of dual - parented pups turned in superior performances on tests of cognitive ability and social skills than mice raised by single parents.

When they next measured responses in the auditory regions of the brain, a more sensitive test, the mice responded to much quieter sounds: 19 of 25 mice heard sounds quieter than 80 decibels, and a few could heard sounds as soft as 25 - 30 decibels, like normal mice.

As the mice aged, their motor performance on a rotarod test (which measures how long the mouse can remain on a rotating rod) became impaired and the length of their strides were significantly shorter than the wild type control mice.

Alzheimer's mice that received AF267B, they found, performed significantly better on this test than untreated mice did.

The researchers also tested a Runx2 knock - down variant of a human multiple myeloma cell line and found that it produced significantly less tumor growth in immunodeficient mice than the original human multiple myeloma cells.

In the new study, Ji's group put SHANK3 - deficient mice through a battery of sensory tests, finding that the animals had lower sensitivity than normal mice to heat and heat - related pain — akin to the soreness a person feels after a sunburn.

Initial tests on mice showed the hybrid virus was very efficient: the gene it carried was active in 24 per cent of airway cells after two months, a far better proportion than achieved by other delivery methods (New Scientist, 10 March 2001, p 19).

«The researchers also overdosed the mice tested in their study with levels of the ingredient at a rate hundreds of times greater than what would be consider a safe use level (based on EPA standards),» DeLeo said in an email.

In subsequent tests, the mice with the mutation did a worse job than normal mice at learning new motor skills.

When tested under a microscope, these human astrocytes accomplished calcium signaling at least three times faster than the mouse astrocytes did.

Speroni said, «We now have a way to test the impact of endocrine - disrupting chemicals on the development of the mouse mammary gland at different doses and obtain results in less than a week.»

However, the young mice given THC performed worse in some tests than the controls.

The old mice also performed significantly better than untreated animals on tests of learning and memory.

Results showed that after the reminder of the fear and after the test for fear relapse, those mice given alcohol had many more GluR1 receptors with phosphates at the edge of the synapse than did mice given only water.

If expertise in using a computer mouse doesn't generalize to other motor skills, migrant workers without previous computer experience should do far worse than the other two groups on these other tests.

When assessing the device's sensitivity with spiked mouse serum samples, the researchers were able to detect HIV and HCV antibodies at 300 picograms per mL and 750 picograms per mL, respectively — values lower than currently existing HIV and HCV antibody tests.

To test the hypothesis, Frankland and his team first compared the stability of memories in adult mice versus 17 - day - old mice, which are equivalent to human babies less than a year old.

The researchers also tested the pathogenicity of the virus by using it to infect mice, which succumbed more quickly than mice infected with other H5N1 strains.

Green says that the treatments may last longer in humans than in mice, but clinical trials will not begin before further testing in other animals.

Testing their microparticles in mice, the team found that the drug persisted in their eyes for at least 14 weeks, more than three times as long as the current treatment.

In vivo tests on mice then confirmed the presence of more than half of the predicted metabolites, including two novel metabolites, which play a role in the pathways that regulate microbiota metabolism as well as host immune function.

Remarkably, stimulating these neurons during social dominance tests one day affected the mice's performance — without any stimulation — the next day; mice receiving more than six photostimulated wins all maintained their new rank, whereas most mice receiving fewer than five photostimulated wins returned to their original rank, the authors report.

Tests in mice and nonhuman primates had shown TGN1412 to be safe, but when it was injected into humans — in a dose less than 1/500 of what was given to monkeys — it caused a massive release of infection - fighting T cells that overstimulated the patients» immune systems, resulting in multiple organ failure.

One double - stranded RNA his lab tested was able to inactivate hepatitis B for more than a year without any apparent harm to the mice.

«We need to test animals bigger than mice,» he said.

Now, MIT engineers have developed a far more sensitive way to reveal ovarian tumors: In tests in mice, they were able to detect tumors composed of nodules smaller than 2 millimeters in diameter.

Further testing in the laboratory dish showed that hematopoietic stem cells from the sleep - deprived mice responded less strongly than their peers to naturally occurring chemical signals that trigger cellular migration.

Further testing found these mice had lower - than - expected growth hormone and insulin - like growth factor (IGF1) levels in the blood, potentially explaining the small stature and delayed development seen in human patients.

Next came the ultimate test: would sperm from polygamous males be more successful at producing offspring than sperm from monogamous mice?

Rich and colleagues are now testing in mice whether combining Zika with traditional cancer treatments such as chemotherapy is more effective than either treatment by itself.

Their methods provide more accurate results than tests on mice and pigs.

Malcolm Eames of the BUAV says Harvard supported its patent application by claiming that tests of potential carcinogens would need fewer onco - mice than normal mice.

Young people also perform worse in learning and memory tests in the hours and days after smoking cannabis, but a joint delivers far higher doses than the mice received.

Rather than merely a cumulative effect, Meyer says, the two conditions appeared to act in synergy, increasing anxiety behaviors in the mice as well as damaging their performance on tests for associative memory and other basic cognitive skills associated in people with a range of neurological disorders, including schizophrenia.

At 14 months, however, the J20 / caspase -2 null mice did significantly better in the water maze test than the J20 mice and similarly to the normal mice.

They found that genetically deleting microRNA - 17 ~ 92 slowed cyst growth and more than doubled the life spans of some mice tested.

Next the team gave the mice a battery of behavioral tests that required them to poke their nose at panels in their enclosure to indicate which of three panels was a different color than the other two.

Oncotest, for example, provides drug - testing services to 16 of the 20 largest pharmaceutical companies, using a library of more than 350 PDX mouse models.

In an operant test R6 / 2 transgenic mice (240 - CAG repeats, B6 congenic background) were less able to acquire lever pressing than control animals at an age where motor function is only mildly affected (from 9 weeks), with this deficit being both more pronounced and detected earlier (from 5 weeks) where reinforcement was not solely contingent on responding.

«In our mouse model of MHE, we were able to reduce bone tumors by more than 90 percent, which is a significant improvement over the previous drugs we have tested in the same mouse model.»

The new MIT system appears to work for many cell types — so far, the researchers have successfully tested it with more than a dozen types, including both human and mouse cells.

EEG studies demonstrated that although C57BR / cd mice spend less time sleeping, a greater proportion of their sleep time is spent in paradoxical sleep (PS)(equivalent to human rapid eye movement, or REM sleep) than is true of mice of six other inbred strains tested (Pagel et al. 1973).

According to tests performed on mice and rabbits, the new vaccine stimulated an immune response to 72 of the more than 90 known strains of S. pneumoniae.

AFF 1: Preclinical Efficacy Data AFF 1 was then tested for preclinical efficacy in two models of human synucleinopathy: mThy1 - AS mice, and also PDGF - AS mice expressing WT human AS under the PDGF - β promoter — a model with closer neuropathological and metabolic resemblance to LBD than PD.

A group of scientists has redesigned and tested a harmless virus that can efficiently deliver a «gene silencing» message throughout the brain in mice, much further than naturally occurring viruses can reach.