Given the role of serotonergic neurotransmission in cognitive control and impulsivity (Gorwood et al. 2000; Mann et al. 2001; Purselle and Nemeroff 2003; Retz et al. 2004; Strobel et al. 2007; Walderhaug et al. 2007; see, however, Clark et al. 2005 for negative evidence), the current findings of greater error - evoked
thalamic activity in women seem to indicate a potentially useful intermediate neural phenotype to further elucidate gender differences in depression.
That could explain Melendez and others like him who improve on Ambien: The drug might boost
thalamic activity by blocking activity in the globus pallidus, which normally keeps the thalamus in check.
The most consistent regional finding is that anesthetics reduce
thalamic activity and deactivate mesial (middle) and parietal cortical regions.
Not exact matches
They found that altering the
activity of three specific targets — GABAB currents, the potassium leak currents and hyperpolarization - activated
thalamic currents — restored sleep patterns in their model.
In these studies, we developed a method to simultaneously record the
activity of multiple excitatory
thalamic neurons (ETN) together with the axonal
activity of inhibitory
thalamic neurons (ITN) in the same brain volume.
The findings provide cross-modality confirmation of PET studies demonstrating increased
thalamic and subgenual cingulate
activity in major depression.
YanGang Sun, Juan Pita - Almenar, Chia - Shan Wu, John J Renger, Victor N. Uebele, Hui - Chen Lu, Michael Beierlein (2013) «Biphasic cholinergic synaptic transmission controls action potential
activity in
thalamic reticular nucleus neurons», Journal of Neuroscience 33: 2048 - 59.
Juan Diego Pita - Almenar, Dinghui Yu, Hui - Chen Lu, Michael Beierlein (2014) «Mechanisms Underlying Desynchronization of Cholinergic - Evoked
Thalamic Network
Activity», Journal of Neuroscience 34 (43): 14463 - 14474.
Significance of the
Thalamic Reticular Nucleus GABAergic Neurons in Normal and Pathological
Activity of the Brain