Sentences with phrase «thalidomide as»

Patients have received bortezomib, lenalidomide, and thalidomide as prior treatments.

In the late 1950s and early 1960s, doctors prescribed thalidomide as an antinausea drug for pregnant women with a regularity that proved tragic.

Not exact matches

The company challenges the claim that thalidomide can cause limb defects that are confined to one side of the body, as seen in nine of the plaintiffs.

Conventional wisdom has long held that thalidomide's signature defect — a shortened, seal - like «flapper» arm, known as phocomelia — affects both sides of the body.

There are no babies rendered obviously deformed, as with thalidomide.

One victory: Gilla Kaplan, now a researcher at the Public Health Institute in Newark, New Jersey, found that the drug thalidomide — banned in 1962 after it was linked to severe birth defects — could reduce inflammatory responses and might be valuable in managing HIV, tuberculosis, cancer, and autoimmune diseases such as lupus.

The company in - licensed thalidomide in 1992 and received FDA approval to market the drug (as Thalomid) for treating severe cutaneous manifestations of leprosy in 1998 and for treating multiple myeloma in combination with dexamethasone in 2006.

Ito and colleagues hope the identification of cereblon as a target for thalidomide teratogenicity will lead to rapid screening for similar, safer alternatives.

Worldwide, roughly 10,000 affected children nicknamed «thalidomide babies» were born with multiple defects, including the characteristic shortened upper limbs (a condition known as phocomelia, Greek for «seal limbs»), before the drug was discontinued in 1961 after four years on the market.

Most recently, he said it might lead to similar health problems as the drug thalidomide.

To test the potential of the system as a drug - screening tool, the researchers exposed the differentiating cells to thalidomide, a drug known to cause severe birth defects.

«Ultimately, we don't want anyone to be using a drug as hazardous as thalidomide,» she says.

But the American and European research communities didn't regard randomized field trials as essential until the 1950s, when Jonas Salk discovered the polio vaccine and Sen. Estes Kefauver held hearings on the testing of thalidomide and other drugs.

The pain of Metroid Prime 2 is something of a literal thing as well, as my hands twisted into curled thalidomide claws after hours of locked - on strafing.

THE NEWS THESE DAYS is rarely good, but two stories in recent editions of the newspaper were truly shocking: a posse of 15 policemen had stormed the Contemporary Arts Center in Cincinnati and, temporarily, closed down the traveling exhibition «Robert Mapplethorpe: The Perfect Moment»; and further, medical researchers had suggested that the drug thalidomide be reintroduced on the market as an effective therapeutic treatment

He was well known for playing a crucial role, as an expert witness, in winning compensation for the victims of thalidomide.

In other work, Henning Moelle has been acting as international lead counsel for the pharmaceutical company Grünenthal in product liability claims for alleged birth defects caused by thalidomide.