Sentences with phrase «thalidomide in»

Dr. Kelsey, 69, was honored for her successful crusade to prevent the marketing of the sleeping pill thalidomide in the United States.

The company in - licensed thalidomide in 1992 and received FDA approval to market the drug (as Thalomid) for treating severe cutaneous manifestations of leprosy in 1998 and for treating multiple myeloma in combination with dexamethasone in 2006.

Not exact matches

That thalidomide was not approved for sale in the United States was more of a bureaucratic fluke than anything else.

For some time, no one suspected that thalidomide was the cause of the significant increase in the incidence of phocomelia.

The company challenges the claim that thalidomide can cause limb defects that are confined to one side of the body, as seen in nine of the plaintiffs.

When asked by Nature for relevant studies, the plaintiffs» lawyers at Hagens Berman Sobol Shapiro in Seattle, Washington, pointed to work showing one - sided limb defects in chick embryos exposed to thalidomide and thalidomide analogues (C. Therapontos et al..

In a new twist of a historic tragedy, 13 Americans who say they are survivors of thalidomide are suing four companies for producing and distributing the notorious drug.

The lawsuit, filed in a Philadelphia court on 25 October, asserts that before thalidomide was pulled from markets around the world, samples were doled out to more than 1,200 physicians in the United States by three companies whose legal liabilities are now the property of Sanofi - Aventis US, based in Bridgewater, New Jersey.

«There are no representative, controlled studies documenting the true spectrum of thalidomide injuries,» they write in the lawsuit.

Holmes also notes that the relative paucity of thalidomide births in the United States means that few researchers there can speak with authority on the drug's effects.

The pharmacologist felt the animal studies submitted were not a good indication of possible toxicity in humans, since animals absorb thalidomide poorly.

President John F. Kennedy honors FDA medical officer Frances Kelsey in 1962 for her work blocking U.S. approval of thalidomide.

Meanwhile, reports of startling birth defects in babies born to mothers who had taken thalidomide were surfacing in Germany, Australia and other countries where the drug was legal — including Kelsey's native Canada.

In July 1962, a detailed story about America's close call with thalidomide appeared on the front page of The Washington Post, under the headline «Heroine of FDA Keeps Bad Drug Off Market,» with a photo of Kelsey.

By November 1961, thalidomide was taken off the market in Germany, and other countries soon followed.

For example, in its current work, the team showed that the micro-hearts didn't develop properly if exposed to thalidomide, a drug that infamously resulted in birth defects when pregnant women took it to treat morning sickness.

The change came about after a massive scandal surrounding the drug thalidomide, which in the 1950s was widely prescribed to pregnant women to alleviate morning sickness.

FDA medical officer Frances Oldham Kelsey averted the tragedy of thalidomide birth defects in the United States

One victory: Gilla Kaplan, now a researcher at the Public Health Institute in Newark, New Jersey, found that the drug thalidomide — banned in 1962 after it was linked to severe birth defects — could reduce inflammatory responses and might be valuable in managing HIV, tuberculosis, cancer, and autoimmune diseases such as lupus.

Starting in 2008, Marzia Lazzerini of the Institute for Maternal and Child Health in Trieste, Italy, and her colleagues randomly assigned 54 children with Crohn's to get daily thalidomide or a placebo.

A new study published in the March 12 issue of Science has identified one primary target of thalidomide's teratogenicity (potential to cause fetal malformations)-- a protein called cereblon.

Worldwide, roughly 10,000 affected children nicknamed «thalidomide babies» were born with multiple defects, including the characteristic shortened upper limbs (a condition known as phocomelia, Greek for «seal limbs»), before the drug was discontinued in 1961 after four years on the market.

In a related report former WHO Global Leprosy Program team leader Vijaykumar Pannikar wrote, «It can not be overemphasized that any potential benefit with thalidomide must be balanced with the known toxicity and the accompanying ethical and legal constraints on its use.»

In both zebrafish and chick embryos, adding a version of cereblon that doesn't bind to thalidomide seemed to blunt the drug's effects.

Handa's team found that beads tagged with thalidomide bound to a little - known protein called cereblon, which is expressed widely in both embryonic and adult tissues.

That, in turn, could finally relegate thalidomide to the history books.

But given that the protein is found in so many tissues, it's puzzling that thalidomide has such specific effects on limbs, ears, eyes, gut, and kidneys.

The prime example is thalidomide, which was outlawed in the 1960s because it caused birth defects but has now found a niche in the treatment of cancer and leprosy.

In the late 1950s and early 1960s, doctors prescribed thalidomide as an antinausea drug for pregnant women with a regularity that proved tragic.

When they gave thalidomide to seven HHT patients, six had significantly fewer nosebleeds within a month of their first dose, Mummery and colleagues report online today in Nature Medicine.

More than 10,000 children in 46 countries were born with missing limbs and other deformities before thalidomide's manufacturers pulled it from the market.

A pilot study of thalidomide, published in 2001, found the drug improved blood counts in some patients and enabled others to become transfusion - independent.

Distinct non-cancer drugs already investigated in clinical cancer trials comprise metformin, aspirin, hydroxychloroquine and thalidomide [3, 4].

It's important to know if the agent in question is perfectly safe or has the potential to be lethal or cause limb defects like thalidomide did,» Bushdid said.

It went on sale under many names in more than 40 countries, but is best known by a brand name that can still strike a chill in those born in the late 1950s: thalidomide.

Will some ed - tech products come to be viewed in the same way people now view the miracle drug thalidomide?

THE NEWS THESE DAYS is rarely good, but two stories in recent editions of the newspaper were truly shocking: a posse of 15 policemen had stormed the Contemporary Arts Center in Cincinnati and, temporarily, closed down the traveling exhibition «Robert Mapplethorpe: The Perfect Moment»; and further, medical researchers had suggested that the drug thalidomide be reintroduced on the market as an effective therapeutic treatment

He was well known for playing a crucial role, as an expert witness, in winning compensation for the victims of thalidomide.

In other work, Henning Moelle has been acting as international lead counsel for the pharmaceutical company Grünenthal in product liability claims for alleged birth defects caused by thalidomidIn other work, Henning Moelle has been acting as international lead counsel for the pharmaceutical company Grünenthal in product liability claims for alleged birth defects caused by thalidomidin product liability claims for alleged birth defects caused by thalidomide.

Comparisons could be made to thalidomide victims or unborn children who are injured in a road traffic accident.

Meyer had said among other things that for 30 years the Contergan (thalidomide) manufacturer Grunenthal GmbH had had access to the medical files of the Contergan victims in the Contergan Foundation.

Representing Grünenthal on the major product liability case involving a claim for damages in over $ 204m filed by the Spanish Association AVITE (Asociación de Víctimas de la Talidomida en España) representing 184 victims of thalidomide, for alleged damages caused in the 1960's for the administration of thalidomide.