Sentences with phrase «than ad mice»
Results from this two - day water maze show that AD mice take considerably longer to find the hidden platform on Day 2 than AD mice treated with J147 for three months (Figure 1A), demonstrating that J147 significantly improved the spatial navigational memory in aged, transgenic AD mice.
https://alzres.biomedcentral.com/ Not exact matches
hAPP mice, but not MCI - AD patients, navigated more slowly than did their respective controls (Supplemental Figure 1), which may have impacted the latency rank - summary score.
In some ways, hAPP mice better model the earlier mild cognitive impairment stage of AD (MCI - AD) than the dementia stage (10).
«The successful retrieval of memories in AD mice by increasing the number of spines for normal memory processing only in the memory cells, rather than in a broad population of cells, highlights the importance of highly - targeted manipulation of neurons and their circuits for future therapies.
«The successful retrieval of memories in AD mice by increasing the number of spines for normal memory processing only in the memory cells, rather than in a broad population of cells, highlights the importance of highly - targeted manipulation of neurons and their circuits for future therapies,» said Tonegawa in a statement.
(10) The company's scientists also report that when they then injected preformed AS fibrils into the brains of mice, BIIB054 slowed the self - templating spread of AS pathology across the brain (consistent with their cell - culture study), and held much of the ensuing motor dysfunction at bay (9,10)(reducing it «by more than 50 percent» according to a science journalist who was present when they presented results at AD / PD 2017 (11)-RRB-.
Mice were caged in groups of no more than five, fed mouse chow and given water ad libitum, and provided huts, bedding and chewable items for enrichment.
In a study involving dietary ketosis via a low carbohydrate diet (less than 10 percent of total calories), compared to subjects on a 50 percent carbohydrate diet, the low - carbohydrate subjects demonstrated better performance on memory tests, with higher scores being correlated to higher serum KB levels.14 A study using cultured mouse hippocampal cells showed that addition of the KB β - hydroxybutyrate (β - OHB) to cells exposed to Aβ resulted in no decrease in the numbers of dendrites or total neurons — two of the noted pathological changes in AD.
Mice on a 60 % fat diet were far healthier eating IF than ad libitum, but also fitter than mice given a 13 % fat diet as contMice on a 60 % fat diet were far healthier eating IF than ad libitum, but also fitter than mice given a 13 % fat diet as contmice given a 13 % fat diet as control.