Sentences with phrase «than animal models»

Because each patient has a different pattern of disease onset and duration, this model may replicate Huntington's more faithfully than animal models do.

Achieving that goal, says Ingber, will require proving that the devices are «as good as or better than animal models.»

The end goal is to create a system that can be used to test drugs that is more accurate and reliable than animal models.

«They are more true - to - life than cells in dishes and more human - like than animal models,» said Hamilton.

Not exact matches

What's more, this research actually confirms the creationist view (and the particlar flood model) that animals can adapt much faster than evolutions say

Headquartered in La Mirada, Calif., its specialized market segments encompass six distinct distribution business units: FoodTech, Nutraceuticals, Animal Wellness, Advanced Materials, Coatings and Building Materials and Care Elements For more than 50 years, HORN's entrepreneurial approach to customer service embraces challenge and opens opportunities to reinvent and improve on traditional business models.

In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.

10 There is no animal model of SIDS and it has never been observed to occur naturally in any species other than humans.2 While the standardization of a SIDS diagnosis has been and continues to be elusive and / or inconsistent, it is most often applied to situations in which an otherwise healthy infant between the ages of 8 - 16 weeks, especially, but up to 12 months, dies suddenly and unexpectedly presumably during its sleep and upon postmortem examination no apparent internal causal factor (s) explaining the death can be identified.11, 12

In a paper published in the journal Systematic Biology and delivered at the Society for Molecular Biology and Evolution Conference this week, Dr Phillips said biases in models of DNA evolution inflated estimates of when modern mammals, which were once no larger than a guinea pig, diversified and evolved into the animals familiar to us today.

Computer models suggested that the hotspots are optimal sites for no - fishing zones because they contain many species, but lower numbers of animals than elsewhere, perhaps because of competition between species.

«Our findings confirm in humans what has been shown in animal models — that maternal obesity has a more significant impact on the body composition of boys than girls,» said Dr. Andres.

Strategies that boost the cell's quality control programs, rather than disarm specific pathologic proteins, have looked promising in lab animals that serve as models for human neurodegenerative disorders including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.

One 2014 study based on modeling animal movement found that increasing vehicle density on existing roads, rather than adding more roads with lower density, resulted in fewer wildlife fatalities.

Using animal models of precancerous polyps in the bowel, Chung and his team determined that certain types of immune cells within a chronically inflamed intestine can become rewired, causing them — paradoxically — to contribute to disease development rather than protect against it.

«This shows that the nanoparticle - encapsulated drug is more effective in tumor reduction than the drug alone in these animal models,» says Le.

«This model is more realistic than traditional animal models because it is derived from a patient's own cells.»

«The nature of this research allows us to study the mechanisms of injury and recovery directly in humans rather than in animal models,» Dr. McCrea said.

By using new techniques based on computerised X-ray micro-tomography (CT scan) and digital three - dimensional modelling, Benoit found that the maxillary canal of therapsids, a bony tube in the snout of the animal that houses the trigeminal nerve, is shorter in therapsids than in reptiles.

Dennis Barbour, MD, PhD, associate professor of biomedical engineering in the School of Engineering & Applied Science who studies neurophysiology, found in an animal model that auditory cortex neurons may be encoding sounds differently than previously thought.

Together with his colleagues, he modeled the vulnerability of more than 700 European plant and animal species to future climate change.

«The dog has a retina very similar to ours, much more so than mice, so when you want to bring a visual therapy to the clinic, you want to first show that it works in a large animal model of the disease,» said lead researcher Ehud Isacoff, professor of molecular and cell biology at UC Berkeley.

«In less than a year, our group and others have demonstrated that multiple vaccine platforms can provide robust protection against Zika virus challenge in animal models.

Researchers gave animal models an oral supplement of spermidine and found that they lived longer and were less likely than untreated individuals to have liver fibrosis and cancerous liver tumors, even when predisposed for those conditions.

Using a mathematical model that combines a huge number of cattle and badgers that have TB, the researchers were able to quantify the relationship between the two animals and use a big data approach to show that the route of infection for cattle is from other cattle rather than from other species.

Rather than «making an 80 - year - old grandma pregnant,» Tilly says, his research aims to create an animal model for studying the health benefits and risks of prolonged ovarian function.

In an animal model of AML, treatment with a combination of FLT3 - and SYK - inhibiting drugs was significantly more effective than treatment with either drug alone.

«You can not really test the idea that animal reservoirs are important other than building a model from the data available.

«With this novel animal model, we showed how it enhances fear rather than reducing it and where the molecular changes are occurring in our central nervous system.»

Such animals would be better than existing animal models for testing potential new treatments, he suggests.

«Because plants make their decisions based on physiological processes and are not distracted from the best course of action by subjective thought, they could even be better models than animals and people,» says Bernhard Schmid from the University of Zurich.

«By using an animal model to expand tumor cells recently removed from patients, we hoped to re-create more closely what actually happens in patients with pancreatic cancer rather than by using existing artificial cell lines,» said Wei Zhang, Ph.D., an endowed Hanes and Willis Family Professor in cancer at Wake Forest School of Medicine, a part of Wake Forest Baptist, and principal investigator of the study.

Elucidation of the molecular basis of mood changes occurring with an infradian (longer than a day) rhythm has been hampered by the lack of an animal model that exhibits spontaneous behavioral changes related to the infradian oscillation of mood.

Such models are valuable for the analysis of parameters associated with vaccine safety, immunogenicity, delivery and protection as NHPs replicate key features of the human immune response more faithfully than any other animal model.

If the marriage of stem cells and CRISPR follows a similar path, it might not be long before pigs have enough Homo sapiens in them not only to grow human hearts, lungs, livers, and kidneys for transplant but also to model human diseases more closely than current lab animals do and to test experimental drugs.

Martinez - Trujillo, a member of Western's renowned Brain and Mind Institute, notes that most spatial memory experiments include animal models being tested in actual, real - world mazes while humans are assessed virtually, using computer screens, more often than not in a two - dimensional setting.

There's more to these findings than just lofty philosophical quandaries, though: If ravens really do possess a level of social cognition comparable to humans and other large primates, the birds might serve as better animal models to study this kind of behavior in the lab — which could help scientists understand why some humans are better at this kind of inference than others, and why some individuals can't manage it at all.

Subsequently, work in the Markou laboratory showed that these compounds had desirable effects on nicotine dependence in animal models, while offering a better side - effect profile than other alternatives under study (full agonists at the same receptors).

The fruit fly is the ideal animal model because the molecular structure of its ear is more similar to humans than that of rats or guinea pigs, meaning tests on fruit flies yield more accurate results.

«If there are ways other than animal studies to get results — in vitro models of toxicity being one of them — we should pursue them,» he said.

Microscopic models — half living, half not — may prove more reliable than animals in explaining human disease and testing therapies.

In some studies of AD animal models, 5 — 6 months of exercise produced greater improvements in behavior or reductions in Aβ than 1 month of exercise (Adlard et al., 2005b; García - Mesa et al., 2011).

We propose that in this animal model the age - associated decrease in hepatic (rather than peripheral) insulin action is the major determinant of fasting hyperinsulinemia and that increased visceral adiposity plays the major role in inducing hepatic insulin resistance.

«But surprisingly, in the animal models, GFAP was turning over more quickly in animals with Alexander disease mutations than in ones without those mutations.»

Our platform is designed to emulate human biology more accurately than current cell culture or animal models, and we are currently working with a diverse group of partners to test the way drugs, foods, and chemicals affect human health.

Meanwhile, CRISPR also makes it easier to edit the genomes of relatively large animals, whose metabolism, physiology and anatomy are closer to humans than previous models have been.

Cornelia Bargmann has for more than two decades used these millimetre - sized transparent worms as a model organism for understanding how genes and the environment influence animal behaviour.

CRISPR not only allows researchers to create these animals faster and more precisely than before, but also to move beyond a relatively small menagerie of standard model species — fruit flies, mice, zebrafish — to create a Noah's ark of mutant dogs, pigs, primates and more.

Conduct clinical trials in a petri dish using the actual affected human cell types — from patients rather than from surrogate models (e.g. animals).

If we equate de facto ketogenic diets with high - protein diets (which is not always correct) then the risks proposed by critics of this type of dietary approach are essentially those of possible kidney damage due to high levels of nitrogen excretion during protein metabolism, which can cause an increase in glomerular pressure and hyperfiltration.12 There is not wide agreement between studies; however, some infer the possibility of renal damage from animal studies, 99, 100 whereas others, looking at both animal models, meta - analyses and human studies, propose that even high levels of protein in the diet do not damage renal function.101, 102 In subjects with intact renal function, higher dietary protein levels caused some functional and morphological adaptations without negative effects.103 There may actually be renal - related effects, but on blood pressure rather than morphological damage.

Another study showed that women who were light drinkers had less weight gain and less risk of obesity than those who drank no alcohol, in addition a study using animal models found that the resveratrol also helped increase exercise endurance.