* The fact is that because cancer cells reproduce more rapidly
than any other cell in the body, mutations occur in cancer cells in far greater numbers.
Thanks to decades of work by Dr. Steinman and other CRI investigators, it is now known that DCs are exceptionally powerful initiators of immunity, with the ability to activate an immune response up to 100 times more potent
than any other cell in the immune repertoire.
Not exact matches
But like many
other, overly optimistic hydrogen - based fuel entrepreneurs, Dean, whose company made a specialized membrane that was to be used
in the fuel -
cell modules, watched the ground open beneath his feet as the commercial take - up proved to be far slower
than anyone anticipated.
There were 38,000 workers
in solar manufacturing
in the U.S. at the end of 2016, according to SEIA, adding that all but 2,000 made something
other than cells and panels, the subject of the trade case.
And
other carmakers like Toyota Motor and Honda are investing heavily
in eco-friendly cars; however, they are betting big that the vehicles will be powered by hydrogen fuel
cells, rather
than rechargeable electric batteries.
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth
in revenues for its antiviral and
other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures
in European countries that may increase the amount of discount required on Gilead's products; an increase
in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger
than anticipated shift
in payer mix to more highly discounted payer segments and geographic regions and decreases
in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations
in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations
in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or
other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials
in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations
in Gilead's earnings; Kite's ability to develop and commercialize
cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates
in the timelines currently anticipated; Gilead's ability to receive regulatory approvals
in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over
other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta
in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes
in its stock price, corporate or
other market conditions; fluctuations
in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and
other risks identified from time to time
in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
BioNTech, which has around 700 employees at sites
in Germany — more
than any
other unlisted biotech firm
in Europe — is also working on
other cancer - fighting technologies, including antibodies,
cell therapies and small molecules.
«Many investors expected a more lengthy FDA review process of the JCAR015 trial (and potentially
other CAR - T programs) and feared that a higher - degree regulatory scrutiny could increase the development risk of CAR T
cell,» Leerink Research said
in a note co-authored by analysts Michael Schmidt, Ph.D., Jonathan Chang, Ph.D., and Varun Kumar, Ph.D. «While it may take several weeks to reopen all clinical sites of the ROCKET trial, we believe the trial shouldn't be delayed by more
than ~ 3 months.»
No embryo has been generated, no organism «cloned» if ANT - OAR succeeds
in its goal of producing nothing
other than pluripotent stem
cells.
... yeah suzy and
others... I just happen to realize that when monkey devolving didn't quite work out on paper it all changed to single
cells and from the slime off of the worlds garbage can and so on... I just happen to know more
than you think...
In another ten or twenty years the science books will all have a new teaching... the Bible has been around and hasn't changed one word in over two thousnad years
In another ten or twenty years the science books will all have a new teaching... the Bible has been around and hasn't changed one word
in over two thousnad years
in over two thousnad years..
The individuals
in these groups, moreover, are regarded as
cells of an organic whole rather
than as persons interacting with each
other in relations some of which are of a more and some of a less determined nature.
Birch and Cobb maintain that the ecological model is more adequate
than the mechanical model for explaining DNA, the
cell,
other biological subject matter (as well as subatomic physics), because it holds that living things behave as they do only
in interaction with
other things which constitute their environment (LL 83) and because «the constituent elements of the structure at each level (of an organism) operate
in patterns of interconnectedness which are not mechanical» (LL 83).
81), but
in their effort to refute such a view, I see no effective reason given
other than the high level of complexity of interactions
in the
cell.
It is
in this way that you should feel towards your clothes, your books, your
cell, and everything else that you make use of; if ordered to quit them, or to exchange them for
others, have no more sorrow
than if you were a statue being uncovered.
We need no further evidence,
in my view, to prove scientifically that the social
in - folding which we are undergoing is nothing
other than the direct and logical extension, over our heads, of the process of cosmic
in - folding which gave birth to the first
cell and the first thought on earth.
Modern psychosomatic medicine has made some progress
in analyzing along these lines; for example, it seems quite possible that the emotional tone of my soul may directly alter the patterns of physical feeling
in my stomach.4 Still, we should not suppose too quickly that the aims of a human personality have any very effective direct influence on the molecules of body
cells,
other than those
in the brain.
More is known about these processes
in the bacterium Escherichia coli
than in other cells.
Other kinds of congenital anomalies that are sometimes found with this condition are, as previously mentioned, Down Syndrome, shorter intestines
than normal, lower birth weight, and an imbalance of electrolytes, which are the elements
in the blood, tissue and
cell fluid needed to help the person balance their energy.
Choose an obstetrician or health care provider Interview potential doctors Contact health insurance company about coverage Start and pregnancy and birth budget Discuss financial effects of pregnancy and baby with partner Stop smoking Stop drinking Stop using street drugs Talk to your physician about any prescription medications Drink at least 8 glasses of water every day Visit the doctor at least once per month or every 4 weeks Do not dye or perm hair Stop drinking coffee and
other caffeinated beverages Exercise daily Start taking prenatal vitamins Eat foods rich
in folic acid Eat iron rich foods Increase daily intake of whole grains, fruits and vegetables Nap as much as possible as fatigue is common Eat fish with low levels of mercury no more
than 2 days per week Do not eat undercooked meats Do not eat unpasteurized dairy producs Do not eat cold cut deli meats Allow someone else to clean out the kitty litter, if applicable Limit exposure to chemicals Try to limit stress and tension Complete all prenatal tests — HIV, Chlamydia, Gonorrhea, Anemia, Blood Typing, Sickle
Cell Anemia, Urine Screening and Rubella.
In 2011 researchers found that these waves of electricity cause neurons in the hippocampus, the main brain area involved with memory, to fire backward during sleep, sending an electrical signal from their axons to their own dendrites rather than to other cell
In 2011 researchers found that these waves of electricity cause neurons
in the hippocampus, the main brain area involved with memory, to fire backward during sleep, sending an electrical signal from their axons to their own dendrites rather than to other cell
in the hippocampus, the main brain area involved with memory, to fire backward during sleep, sending an electrical signal from their axons to their own dendrites rather
than to
other cells.
In 2014, for example, according to data in the article, stem cell researchers between 35 and 39 were successful more often than any other age group, winning grants 21.6 % of the time, as compared to success rates ranging from 18.3 % for those between 40 and 44 to 13.4 % for those in the 55 to 59 age grou
In 2014, for example, according to data
in the article, stem cell researchers between 35 and 39 were successful more often than any other age group, winning grants 21.6 % of the time, as compared to success rates ranging from 18.3 % for those between 40 and 44 to 13.4 % for those in the 55 to 59 age grou
in the article, stem
cell researchers between 35 and 39 were successful more often
than any
other age group, winning grants 21.6 % of the time, as compared to success rates ranging from 18.3 % for those between 40 and 44 to 13.4 % for those
in the 55 to 59 age grou
in the 55 to 59 age group.
The relevant patents involve the positioning of differentiated retinal
cells in the eye and not the creation of these
cells and would potentially be exempt from the ruling; his team wrote its patent this way to distinguish it from
other stem -
cell - based applications — they felt that describing the placement of
cells rather
than the creation of the
cells was likely to be more novel.
Despite the presumed virulence of the strain — experiments with mouse lungs showed it produces 1000 times more bacteria
in infected
cells than do standard varieties — Valway says the number of TB cases that developed were kept
in line with
other typical outbreaks, which «shows that doing good contact investigations is important and preventative therapy works.»
In other words, easy financing makes China - made solar
cells much cheaper
than those from manufacturers who must pay interest on any money borrowed to build factories or install modules.
Base oxidation regulates gene activity
In cooperation with colleagues at LMU, as well as researchers based in Berlin, Basel and Utrecht, Carell and his group have now shown, for the first time, that a standard base other than cytosine is also modified in embryonic stem cells of mic
In cooperation with colleagues at LMU, as well as researchers based
in Berlin, Basel and Utrecht, Carell and his group have now shown, for the first time, that a standard base other than cytosine is also modified in embryonic stem cells of mic
in Berlin, Basel and Utrecht, Carell and his group have now shown, for the first time, that a standard base
other than cytosine is also modified
in embryonic stem cells of mic
in embryonic stem
cells of mice.
In principle, scientists can modify AAVs to infect some
cell types more
than others to deliver their therapeutic payloads where they are most needed.
We know that they are under stress when they are fighting cancer or
other diseases, so I wondered whether anything measureable could be seen if we put them under further stress with UVA light.We found that people with cancer have DNA which is more easily damaged by ultraviolet light
than other people, so the test shows the sensitivity to damage of all the DNA — the genome —
in a
cell.»
We found that the inflammation unfortunately gets hijacked by tumor
cells that are able to grow faster and penetrate deeper because the blood vessels
in the brain are more permeable
than in any
other part of the body.
But researchers dream of being able to create truly elastic electronic components — soft circuit systems that can act more like live
cells, moving around autonomously and communicating with each
other to form new circuits rather
than being stuck
in one configuration.
The payload kills
cells by means
other than genetic destruction,
in contrast to the current standard treatments.
The study published
in Cancer
Cell shows that exosomes from tumor
cells of breast cancer (and
other tumor types such as ovarian and endometrial) are different
in size and composition
than those of healthy
cells.
But rather
than natural diamond, Silvera and Dias used two small pieces of carefully polished synthetic diamond which were then treated to make them even tougher and then mounted opposite each
other in a device known as a diamond anvil
cell.
In dense traffic, cell phone users were about 20 percent slower to respond to sudden hazards than other drivers, and they were about twice as likely to rear - end a braking car in front of the
In dense traffic,
cell phone users were about 20 percent slower to respond to sudden hazards
than other drivers, and they were about twice as likely to rear - end a braking car
in front of the
in front of them.
«Because of their chemical structure, omega - 3's behave very differently
in cell membranes
than any
other fat,» says Susan Allport, author of The Queen of Fats: Why Omega - 3s Were Removed from the Western Diet and What We Can Do To Replace Them.
When stimulated, the
cells» channels open up within microseconds, much faster
than most
other ion channels
in the body.
Initial tests on mice showed the hybrid virus was very efficient: the gene it carried was active
in 24 per cent of airway
cells after two months, a far better proportion
than achieved by
other delivery methods (New Scientist, 10 March 2001, p 19).
Stem
cells harvested from embryos rather
than adults remain the most powerful for cloning and
other purposes; Yang's team showed that cloning from such
cells succeeded
in 49 percent of attempts and led to 18 mouse pups.
FIH is found
in all the body's
cells and tissues, but is 50 to 100 times more abundant
in the muscles
than in any
other part of the body.
In a boost for a controversial theory of aging, mice engineered to make a human protein that sponges up
cell - damaging molecules live 19 % longer
than other mice.
Philip Laipis of the University of Florida, who has also observed tumors
in AAV vector - treated mice, agrees, at least for studies using a similarly high dose of AAV to target liver
cells, which are more likely
than other cell types to take up the AAV vector.
Because the
cells inside the droplets are free - floating, the technique allows them to contact each
other in every direction, as they would
in the human body, rather
than only touch side to side as they do
in a flat dish.
The research suggests that reducing production of the protein, called myoferlin, affects cancer
cells in two primary ways: by changing the activation of many genes involved
in metastasis
in favor of normal
cell behavior, and by altering mechanical properties of cancer
cells — including their shape and ability to invade — so they are more likely to remain nested together rather
than breaking away to travel to
other tissues.
This makes them easier to control
than other types of
cells used
in therapies and makes side effects unlikely.
More
than a decade ago, Clevers identified a type of mother
cell in the gut that can give birth to all
other intestinal
cells.
«
In 2015 we discovered that the brain
cells of people with bipolar disorder are more sensitive to stimuli
than those of
other people,» says Gage.
The microbes rely on oxygen, carbon and
other nutrients
in their deep environment to live, but Røy's team found that carbon is so limited that the
cells respire oxygen 10,000 times slower
than bacteria
in lab - grown cultures.
The research team with international collaborators analysed more
than 100 patient samples from ovarian and
other cancer types to discover a distinct population of
cells found
in some tumours.
Other than in previous publications, optical rogue waves
in this system are clearly ruled by atmospheric turbulence
in a gas
cell, effectively enabling the observation of a storm
in a test tube.
«Simply by counting
cell types, we immediately saw that there were more Tregs
in the older mice with diabetes
than any
other group.»
They looked at white blood
cells called monocytes, a major
cell type involved
in rheumatoid arthritis, and found that those
cells behaved differently
in one group
than in the
other.