These mother cells can pump out drugs more efficiently
than the daughter cells which did not inherit old cell poles.
Not exact matches
Juan Carlos Izpisúa Belmonte of the Salk Institute in La Jolla, California, knew that stem
cells are more useful for gene therapy
than ordinary
cells, because they produce multiple
daughter cells with the modified genes.
Gottschling noticed that after about 25
cell divisions — the equivalent of middle age in humans — DNA errors in
daughter cells started appearing 100 times faster
than normal.
During each
cell division, more
than 3.3 billion base pairs of genomic DNA have to be duplicated and segregated accurately to
daughter cells.
In a previous study, Aldridge and her colleagues demonstrated that mycobacteria divide asymmetrically — despite being genetically identical, one of the two
daughter cells will usually be longer and faster growing
than its twin.
The researchers also found that another population known as progenitor
cells — differentiated
daughter cells of stem
cells — started to behave like stem
cells: They began to live much longer
than their usual lifespan of a few days, and they could also generate mini-intestines when grown outside of the body.
Although counterintuitive, this is reminiscent of the way certain pluripotent stem
cells in other systems express a greater number of genes — including more ancient genes —
than their somatic
daughter cells do.