Sentences with phrase «than gene delivery»

Perhaps, a molecule that could stimulate neurotrophic factors, such as NGF in vivo, would be more efficient, more safe and cost effective than gene delivery directly into the brain.

Not exact matches

Initial tests on mice showed the hybrid virus was very efficient: the gene it carried was active in 24 per cent of airway cells after two months, a far better proportion than achieved by other delivery methods (New Scientist, 10 March 2001, p 19).

With the best - performing particles, the researchers reduced gene expression by more than 50 percent, for a dose of only 0.20 milligrams per kilogram of solution — about one - hundredth of the amount required with existing endothelial RNAi delivery vehicles.

These features enable gesicles to knock out genes with high efficiency and in a broader range of cell types than plasmid - based delivery methods.

«This is important biotechnologically, because if you look at if from the angle of genome editing, the delivery of small genes into cells is much easier than the delivery of large genes,» said Rotem Sorek of the Weizmann Institute of Science in Israel who was not involved in the work.

Given the tailored inhibition of selected genes and the added precision brought by targeted delivery systems, RNAi - based therapies are thought to carry lower risk of failure than traditional approaches as the biological effects are more predictable.

Meanwhile, gene delivery systems other than retro - or lenti - viral ones, such as repeated transfection with plasmids and use of a non-integration virus, have been successfully applied in generation of iPS cells [8], [9].