The p - tau levels are higher in female
than in male mice, and the increased p - tau was consistent with a proportional decrease in the post-synaptic marker levels analyzed.
Not exact matches
«Our research suggests that
in mice,
males may be more vulnerable to the effects of maternal inflammation
than females, and the impact may be life long,» says study leader Irina Burd, M.D., Ph.D., an assistant professor of gynecology / obstetrics and neurology at the Johns Hopkins University School of Medicine and director of the Integrated Research Center for Fetal Medicine.
These epigenetic tweaks were then passed onto
male pups, which produced higher levels of blood sugar - generating proteins
in their livers
than mice sired by unstressed fathers.
In mating experiments, yogurt - eating
males inseminated their partners faster and produced more offspring
than control
mice.
Likewise,
male mice with a Rett mutation have much more severe symptoms
than the females do, says Zhong - wei Zhang, associate professor at the Jackson Laboratory
in Bar Harbor, Maine.
An accelerated progression may show up
in clinical trials
in human
males, who live longer with the disease
than mice.
«It has become more and more obvious that females
in mice, birds, and all sorts of insects are mating with more
than one
male,» Gowaty says, meaning that promiscuity cuts both ways.
Female
mice spent five times as much time
in a place where they had encountered a dish with
male urine
than at a place where they encountered water.
Adult
male mice also started off with fewer of the lymphoid cells
in the lungs
than adult females, the researchers found: Female
mice had about 1 1/2 times as many of these immune cells as
males.
So when Drake and his colleagues measured the RNA levels — a direct link to how much of a gene is being produced —
in the genes of 334
mice, he didn't expect to find more
than a few variations that might help explain why
males and females have such different rates of cardiovascular disease and diabetes or why they react differently to certain drugs.
In addition, despite the genetic deletion, the female deletion
mice have higher levels of ERK1
than the
male deletion
mice.
The team then bred the
mice and checked their offspring for DNA mutations.The
mice born to
males that breathed unfiltered air had up to 2.8 times more mutations
in particular stretches of noncoding DNA
than did
mice with fathers that breathed filtered air, or clean air at a rural site.
The duration (20 minutes) used
in the current study was based on previous work by our group demonstrating attenuation of age - related bone loss
in male mice (36), but this duration is also less
than the 60 - minute protocol shown to promote bone formation
in the study by Jing et al. (44).
When the survival curve of
males and females were plotted independently, the reduction
in viability of p21 - null
mice was more pronounced for females
than for
males (Fig. 1) ⇓.
When the researchers added cocaine to injured
mouse brains, they found that
male mice with concussions had more dopamine building up
in between cells
than did females or non-injured
mice.
Bar Harbor, Maine — A research team led by Jackson Laboratory (JAX) Professor David Harrison, Ph.D., reports that acarbose, a drug that is frequently prescribed
in Europe for type 2 diabetes, extends the lifespan of
mice, with
male mice showing a more pronounced effect
than the females.
In related research, also reported in Aging Cell, the researchers at the three institutions also showed recently that the lifespan - extending effects of rapamycin vary with both dosage of the drug and gender of the mice, with greater effect in females than male
In related research, also reported
in Aging Cell, the researchers at the three institutions also showed recently that the lifespan - extending effects of rapamycin vary with both dosage of the drug and gender of the mice, with greater effect in females than male
in Aging Cell, the researchers at the three institutions also showed recently that the lifespan - extending effects of rapamycin vary with both dosage of the drug and gender of the
mice, with greater effect
in females than male
in females
than males.
7/5/2007 Why Liver Cancer Is More Prevalent
in Males than in Females Production of a protein that promotes inflammation appears to be linked to the higher incidence of liver cancer
in men
than in women, researchers at the University of California, San Diego (UCSD) School of Medicine have determined
in mouse studies.
Although body weight was not different, liver weights were significantly higher (P < 0.01)
in 15 - mo - old
mice derived from IVC
in the presence of FCS
than in control animals (Supplemental Table S2); this phenotype was transmitted to F1 and F2
males derived from F0 IVC
males but was not transmitted to F1 females.
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