This and subsequent similar experiments used guinea pig brains because they're larger and easier to work with
than mouse brains.
The group also found that the virus could be detected in fetal tissues other
than mouse brain tissue, such as the lymph nodes.
It's so much bigger
than the mouse brain, which is kind of an almond - size thing.
The reconstruction of a non-human primate brain, with a volume 100 times larger
than a mouse brain, is being considered for a later study.
Not exact matches
For all the human -
mouse mixing, however, the rodents were no better learners
than those with
mouse - only
brains.
These
mice performed better
than their normal counterparts on learning tests well into old age, and their
brains did not exhibit the decline in neurogenesis typically seen in aged
mice.
«We don't know if the observed reversibility of the disease symptoms as observed in the
mouse,» he says, «exists in humans who have a much longer period of pre - and post-natal
brain development
than mice — months and years in humans, weeks in
mice.»
The Salk team therefore took human
brain organoids that had been growing in lab dishes for 31 to 50 days and implanted them into
mouse brains (more
than 200 so far) from which they had removed a tiny bit of tissue to make room.
Scientists imaged more
than 1,700
mouse brains to build the most comprehensive mammalian
brain map yet.
In 1999 van Praag showed that more new nerves formed in the hippocampus — one of the key centers in the
brain for memory and learning — in physically active
mice than in inactive ones.
When the researchers attached probes to the
mice to measure
brain activity, they found
mice without ErbB4 had
brain regions that were acting independently, rather
than together in synchrony.
The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different
brain mechanisms in
mice than in humans, he says.
In the study, led by post-doctoral fellow Long N. Nguyen of Duke - NUS, researchers found that
mice without the Mfsd2a transporter had
brains a third smaller
than those with the transporter, and exhibited memory and learning deficits and high levels of anxiety.
The team found that humans are equipped with tiny differences in a particular regulator of gene activity, dubbed HARE5, that when introduced into a
mouse embryo, led to a 12 % bigger
brain than in the embryos treated with the HARE5 sequence from chimpanzees.
For instance, Evan's blue, a dye that stains the cellular protein albumin, penetrates the
brain 10 times more efficiently in stressed
mice than in unstressed
mice.
«
Mice that don't have these molecules seem to be able to change their brain circuits with experience much more rapidly than normal mice,» Shatz s
Mice that don't have these molecules seem to be able to change their
brain circuits with experience much more rapidly
than normal
mice,» Shatz s
mice,» Shatz says.
Scientists imaged more
than 1,700
mouse brains (injected with a tracer virus) at resolutions less
than a micrometer, or 50 times smaller
than a human hair.
David Holtzman of Washington University School of Medicine in St Louis, Missouri, and colleagues found that beta - amyloid levels were higher in
mouse brains when the
mice were awake
than when they were sleeping.
When they next measured responses in the auditory regions of the
brain, a more sensitive test, the
mice responded to much quieter sounds: 19 of 25
mice heard sounds quieter
than 80 decibels, and a few could heard sounds as soft as 25 - 30 decibels, like normal
mice.
The HSP70 - boosted
mice were much better
than the others at finding their way around mazes, and post-mortems showed their
brains to be free of the characteristic beta - amyloid plaques that clog the
brains of people with Alzheimer's.
To investigate the longer - term effects of higher -
than - normal acetylcholine levels on the
brain, Hermona Soreq of the Hebrew University of Jerusalem and her colleagues first induced high levels of acetylcholine by forcing 26
mice to swim, an activity stressful to
mice.
A dye used for more
than a century to stain autopsied
brain tissue can prevent the devastating effects of Huntington's disease in
mice, new research shows.
«Caloric restriction in combination with low - fat diet helps protect aging
mouse brains: Low - fat diet plus limited caloric intake prevented aging - induced inflammatory activation of microglia; exercise was significantly less effective
than caloric restriction in preventing these changes.»
Stevens and her colleagues manipulated
mice to make one eye more active
than the other, creating a disparity in activity between the two neural circuits linking the eyes to the
brain.
«I'm not saying that everyone who has influenza is cognitively impaired for 10 years,» he says, noting that human
brains are much more complex
than those of
mice.
The
mice received doses that were proportionally a thousand times greater
than that given to people, along with a toxin that makes the blood -
brain barrier leaky.
Removing a single gene from the
brains of
mice and zebrafish causes these animals to become more anxious
than normal.
Brain changes in the
mice lasted for more
than four months, equivalent to years in humans.
A powerful X-ray tomography scanner allowed the researchers to image particularly thick sections of the
brains of
mice, which afforded them views into intact neural areas much larger
than are customary in microscope imaging.
Then they injected the rodents»
brains with Salmonella bacteria to cause an infection and waited to see whether the
mice making the extra amyloid did better
than controls at fighting off the microbes.
lost less weight, had fewer bacteria in their
brains, and lived up to roughly 30 hours longer
than the control
mice
Once the microglia were mobilized in
mouse models of Alzheimer's disease, the researchers observed a more
than 60 percent reduction in amyloid beta in the
brain.
Levels of A-beta in the blood of
mice that received APOE2 were higher
than in the other groups, suggesting that the protective variant had increased clearance of A-beta from the
brain.
Mouse brains are physically smaller and grow faster
than human
brains.
When Gan imaged their
brains, he found
mice that had slept developed more dendrites — the tiny filaments that allow neurons to communicate —
than did sleep - deprived
mice.
The new study — published October 18, 2016 in the journal Molecular Psychiatry — combined genetic analysis of more
than 9,000 human psychiatric patients with
brain imaging, electrophysiology, and pharmacological experiments in mutant
mice to suggest that mutations in the gene DIXDC1 may act as a general risk factor for psychiatric disease by interfering with the way the
brain regulates connections between neurons.
When the
mice died at 31 weeks, their
brains had 20 % fewer neurons
than normal
mouse brains in regions that Huntington's strikes in people.
In a
mouse brain, the CAQK peptide binds to injured sites more effectively
than the control.
They found that germ - free
mice broke down
brain chemicals associated with anxiety, such as noradrenaline and dopamine, faster
than did the other
mice.
Young
mice paired with old
mice (left chart, two - toned) made fewer new cells in the
brain's hippocampus
than when paired with another young
mouse (yellow).
Using novel technologies developed at HMS, the team looked at how a single sensory experience affects gene expression in the
brain by analyzing more
than 114,000 individual cells in the
mouse visual cortex before and after exposure to light.
Importantly, levels of total tau and tau tangles in the
brains of treated 12 - month - old
mice were lower
than in untreated 9 - month - old
mice, suggesting that the treatment not only had stopped but reversed the buildup of tau.
Old
mice made hundreds more new
brain cells when paired with a young
mouse (right chart, two - toned)
than when paired with an old
mouse (teal).
The microscopy techniques that permit imaging of
brain cells in awake
mice generally can't visualize anything deeper
than a fraction of a millimeter below the
brain's surface, whereas the mPOA is several millimeters deep.
Mice, for example, have
brains that are around a thousand times smaller
than the human one.
Well, human mating is a bit more complicated
than it is for
mice, and our perfumes have far less power over our
brains (whatever the beliefs of pushy department - store perfumers).
As a result, the embryos carrying human HARE5 have
brains that are 12 % larger
than the
brains of
mice carrying the chimp version of the enhancer.
The blue stains in these developing
mice embryos show that the human DNA inserted into the rodents turns on sooner and is more widespread (right)
than the chimp version of the same DNA, promoting a bigger
brain.
Now, Jennifer Rodger from the University of Western Australia in Crawley and colleagues have found that stimulating the
brain at intensities lower
than would make a neuron fire can remove unwanted neural connections in
mice.
The authors also found abnormalities in the subthalamic nucleus occur earlier
than in other
brain regions, and that subthalamic nucleus nerve cells progressively degenerate as the
mice age, mirroring the human pathology of Huntington's disease.