Sentences with phrase «than normal cells in»

«Cancer cells behave differently than normal cells in terms of glucose metabolism,» said Wisner.

«Tumor cells produce larger quantities of H2O2 and use oxidative signals at higher levels than normal cells in order to drive their own growth,» says Mirko Sobotta, first author of the publication.

Not exact matches

And, perhaps most strikingly, a team at a gaggle of New York research institutions published a paper showing how they'd used hPSCs to cook up — in just days, rather than several months — cortical neurons (critical central nervous system cells) that had normal electrophysiological signaling properties.

Catholics take it as literal... The body is certainly not resurrected in terms of the cell, the protoplasm, the DNA... that certainly doesn't happen any more than the wafer turns into [the literal body of Christ]... in the sense in which any normal use of the English language would understand.

Other kinds of congenital anomalies that are sometimes found with this condition are, as previously mentioned, Down Syndrome, shorter intestines than normal, lower birth weight, and an imbalance of electrolytes, which are the elements in the blood, tissue and cell fluid needed to help the person balance their energy.

In experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cellIn experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cellin the face of rising TNF - alpha signals than normal cells.

His lab differentiates iPSCs from autistic patients into neurons and glial cells, which they suspect may be releasing cytokines at levels higher than normal in autistic patients.

Normal mice saw benefits, too: Muscles and pancreas cells healed better in middle - aged mice that got rejuvenation treatments than in mice that did not.

Goadsby doesn't know yet if the brain cells involved are bigger than those in normal patients or if there are simply more of them; that would require the dissection of a brain.

They found — as they did in the 2016 study — that when these cells expressed SOD1 mutants that predominantly form trimers, the cells died much more quickly than control cells containing normal SOD1.

Psoriasis is a disease of the immune system in which inflammation causes skin cells to multiply faster than normal.

The metabolism of bone cells determines how much sugar they use; if the bone cells consume more sugar than normal, this can lower the glucose level in the blood.

«Perhaps there are some mammary gland stem cells that can be coaxed to have a slightly broader potential than normal, but I very much doubt that embryonic - like cells normally exist in the breast,» says Robin Lovell - Badge of the National Institute for Medical Research in London.

In order to generate enough energy, the bone cells in our mice therefore take up much more glucose than normal.&raquIn order to generate enough energy, the bone cells in our mice therefore take up much more glucose than normal.&raquin our mice therefore take up much more glucose than normal.»

Restoring normal function to a mutated protein is more difficult than simply blocking a protein, the strategy used by most medical therapies, says Klas Wiman, a tumor cell biologist at the Karolinska Institute in Stockholm.

Using a technique known as single - cell RNA sequencing, the team explored more than 65,000 individual cells that exist under normal or inflammatory conditions, looking for genes that were more active in one state or subpopulation versus another.

Patients were considered free of MRD if less than one cancer cell could be detected in 1,000 normal bone marrow cells.

Expression of CXCL16 was higher in the colon and lung tissue of GF mice than in normal mice, and blocking that expression reduced the numbers of iNKT cells and the amount of inflammation in those tissues.

The resulting cells mimicked the genetic mutation seen in actual Werner syndrome patients, so the cells began to age more rapidly than normal.

In separate experiments, when Rab32 rises in response to stress in the endoplasmic reticulum, or ER, several things happen: The nerve cell fibers (both axons and the message - receiving dendrites) are shorter, mitochondria are bulkier than normal and their numbers spikIn separate experiments, when Rab32 rises in response to stress in the endoplasmic reticulum, or ER, several things happen: The nerve cell fibers (both axons and the message - receiving dendrites) are shorter, mitochondria are bulkier than normal and their numbers spikin response to stress in the endoplasmic reticulum, or ER, several things happen: The nerve cell fibers (both axons and the message - receiving dendrites) are shorter, mitochondria are bulkier than normal and their numbers spikin the endoplasmic reticulum, or ER, several things happen: The nerve cell fibers (both axons and the message - receiving dendrites) are shorter, mitochondria are bulkier than normal and their numbers spike.

In tests on human brain cells engineered to make more normal prions than usual, Hooper found that the cells secreted far less amyloid beta peptide than they would ordinarily.

The researchers found that mutant mice lacking Del - 1 had more severe attacks of the EAE than normal mice, with more damage to myelin, the fatty sheath that coats neurons and helps in the transmission of signals along the cell.

Moreover, mice engineered to generate smaller than normal quantities of SIRT1 carried relatively little fat in their blood, indicating that their cells hung onto it.

A study by Mo's group in a 2011 issue of Experimental Biology and Medicine (236:604 - 613) showed that normal fibroblasts are 10-fold more resistant than murine B16 melanoma cells to geranylgeraniol - mediated growth suppression.

In the lab, the antibiotics had no harmful effect on normal cells, and since they are already approved for use in humans, trials of new treatments should be simpler than with new drugs — saving time and moneIn the lab, the antibiotics had no harmful effect on normal cells, and since they are already approved for use in humans, trials of new treatments should be simpler than with new drugs — saving time and monein humans, trials of new treatments should be simpler than with new drugs — saving time and money.

By lowering the oxygen in the culture — adding nitrogen to cut it by more than half — the researchers found they could dramatically improve the percentage of stem cells capable of making normal sperm when put back into the testes.

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

In 1924, Otto Warburg showed that cancer cells produced far more energy from glycolysis than did normal cells.

Gottschling noticed that after about 25 cell divisions — the equivalent of middle age in humans — DNA errors in daughter cells started appearing 100 times faster than normal.

In 2001, he discovered that a strain of yeast made up of unusually small cells and colonies lived about three times longer than normal yeast and was highly protected from DNA damage and aging.

They found that normal cells grow faster when in an organoid with cells expressing RasG12V at low levels, but required more than one mutant cell to kick - start this abnormal growth.

The toxicity of chokeberry extract on normal blood vessel lining cells was tested and found to have no effects up to the highest levels used (50 ug / ml), suggesting that the cell death effect is happening in a way other than through preventing new blood vessel formation (anti-angiogenesis), a process that is important in cancer cell growth.

Kass developed the midstream urine test (still used when you pee in a cup) and set a numerical cutoff for the number of bacteria in normal urine: not more than 100,000 colony - forming units (cell clusters on a culture dish) per milliliter of urine.

In their study published online May 9 in the journal Oncogene, scientist Saraswati Sukumar, Ph.D.; her graduate student Wei Wen Teo; and their colleagues show that cells without HOXA5 have an increased capacity to renew themselves and are more invasive than normal breast cells — in short, they become more tumor likIn their study published online May 9 in the journal Oncogene, scientist Saraswati Sukumar, Ph.D.; her graduate student Wei Wen Teo; and their colleagues show that cells without HOXA5 have an increased capacity to renew themselves and are more invasive than normal breast cells — in short, they become more tumor likin the journal Oncogene, scientist Saraswati Sukumar, Ph.D.; her graduate student Wei Wen Teo; and their colleagues show that cells without HOXA5 have an increased capacity to renew themselves and are more invasive than normal breast cells — in short, they become more tumor likin short, they become more tumor like.

In test - tube experiments, WS cells are much more susceptible than normal to harm from a compound that is toxic to DNA.

«The Raman spectroscopy probe has a greater than 92 % accuracy in identifying cancer cells that have invaded into normal brain.»

A strain isolated in Cambodia in 2010 caused some brain cell death, resulting in a slightly smaller brain (middle) than normal (left).

«One of the characteristics of cancer cells is that they tend to have more oxidative stress than normal cells,» said Bret Freudenthal, Ph.D., lead author of the paper and postdoctoral fellow in Wilson's group.

In addition, cells under stress often behave differently than normal cells do, a huge stumbling block for scientists trying to draw connections between their experiments and the natural world.

This happens when an abnormal egg cell in the ovary develops with a full, rather than the normal half, complement of genes, all of them maternal.

They also tested to see if the drug was inhibiting production of normal RNAs in the cells, and found that it altered less than 5 percent of normal RNA sequences

When researchers infected these ERV - depleted cells with the vaccinia virus (which may be related to smallpox), they had a much weaker innate immune response than unedited normal cells, the team reports online today in Science.

Given his training in developmental biology, Raman focused the team to seek a novel drug target on genes important to the development of model organisms — fruit flies (Drosophila) and yeast (Saccharomyces cerevisiae)-- rather than on oncogenes that transform a normal cell into a cancer cell.

One of the expected dangers of cloning is that worn down telomeres will be inherited from the adult cells used in lieu of an egg or sperm cell, and indeed the telomeres of adult clones are often shorter than normal.

These cells have now lived three times longer than normal in the lab, and they are still going strong.

He notes, however, that other attempts to stimulate bone growth in mice by manipulating cell signaling proteins have produced denser than normal bones — and he's surprised that Helms's team didn't see the same.

In another experiment, mice lacking the cells that produce serotonin scratched less than normal mice when exposed to a skin irritant.

Although muscle cells did not reduce in size or number in mice lacking a protective antioxidant protein, they were weaker than normal muscle cells, researchers from the Barshop Institute for Longevity and Aging Studies at The University of Texas Health Science Center San Antonio found.

The cells with the normal gene grew significantly longer dendrites — the portions of the cell that reach out to receive nerve impulses — than did neurons with the mutated gene, the team reports 14 October in Science.

To see what was happening in the brains of these ankyrin - G mutant mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on pyramidal neurons in ankyrin - G mutant mice than in normal mice.