But when they looked at the activity in the bad NMDA channels, they found more in HD mouse brains
than normal mouse brains.
When the mice died at 31 weeks, their brains had 20 % fewer neurons
than normal mouse brains in regions that Huntington's strikes in people.
Not exact matches
These
mice performed better
than their
normal counterparts on learning tests well into old age, and their
brains did not exhibit the decline in neurogenesis typically seen in aged
mice.
The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from
normal activities — but not others, such as stress and anxiety, and probably tap into different
brain mechanisms in
mice than in humans, he says.
«
Mice that don't have these molecules seem to be able to change their brain circuits with experience much more rapidly than normal mice,» Shatz s
Mice that don't have these molecules seem to be able to change their
brain circuits with experience much more rapidly
than normal mice,» Shatz s
mice,» Shatz says.
When they next measured responses in the auditory regions of the
brain, a more sensitive test, the
mice responded to much quieter sounds: 19 of 25
mice heard sounds quieter
than 80 decibels, and a few could heard sounds as soft as 25 - 30 decibels, like
normal mice.
To investigate the longer - term effects of higher -
than -
normal acetylcholine levels on the
brain, Hermona Soreq of the Hebrew University of Jerusalem and her colleagues first induced high levels of acetylcholine by forcing 26
mice to swim, an activity stressful to
mice.
Removing a single gene from the
brains of
mice and zebrafish causes these animals to become more anxious
than normal.
At the same time, the rodents had an even greater response to social defeat stress
than normal mice do, suggesting their
brains also are more susceptible to a depressive - like state.
The
brains of the
mice were smaller
than normal and had fewer neurons in areas that controlled the affected behaviors.
To see what was happening in the
brains of these ankyrin - G mutant
mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on pyramidal neurons in ankyrin - G mutant
mice than in
normal mice.
The researchers measured 40 % more of the enzyme PDE4A5 in the
brains of sleep - deprived
mice than in
normal mouse brains.
Mice with a single missing gene have
brains that are 35 percent larger
than normal, a new study found.