Antidepressants such as Prozac and Celexa have been shown to be better
than placebo at treating hot flashes, and doctors sometimes prescribe these and other antidepressants for hot flashes «off - label» (i.e., without the FDA's official OK).
As for its health benefits, peppermint oil was more effective
than placebo at treating irritable bowel syndrome, a meta - analysis of the clinical literature found, and it was equally effective as pharmaceutical treatments.
While some review studies on the substance indicate St. John's Wort is better
than a placebo at treating mild to moderate depression with fewer side effects than traditional antidepressants, other review studies have found no difference in effectiveness.
A 2002 review of the research on SAMe and depression conducted by the federal Agency for Healthcare Research and Quality concluded that SAMe was more effective
than placebo at relieving the symptoms of depression and no better or worse than tricyclics.
Overall, they concluded, fish oil supplements were no more effective
than placebo at preventing premature death or serious cardiovascular problems.
A study of 172 women suggests that HRT treatment is more effective
than a placebo at preventing symptoms of depression from emerging during early menopause
Not exact matches
At one month, the probiotic group cried or fussed 49 minutes more
than the
placebo group.
The results show that the probiotic group fussed significantly more
than the
placebo group
at all time points from day seven to one month.
Some of the best support for this contention came in 2012, when researchers
at Memorial Sloan Kettering Cancer Center and their colleagues published a meta - analysis of 29 studies involving nearly 18,000 patients, which found that traditional acupuncture produced a somewhat greater reduction in pain
than placebo or sham acupuncture.
Both
placebo and supplements were given once monthly — rather
than daily
at home —
at the GPI to ensure consistent compliance.
Yesterday,
at the annual American College of Rheumatology meeting in Atlanta, Ga., researchers announced the results of a double - blind, randomized trial in more
than 600 patients: tasocitinib eased pain and inflammation in 65.7 percent of those who received the highest dose of the drug, whereas only 26.7 percent of those who received a
placebo reported relief.
The primary endpoint of death and non-fatal heart attack
at 30 days was no different between the two groups (7 percent in the aspirin group and 7.1 percent in the
placebo group); however, major bleeding was significantly higher in aspirin - treated patients
than in the
placebo group (4.6 percent vs. 3.7 percent).
In absolute terms, the overall survival rate
at five years was 11 % higher in the ipilimumab arm (65 %)
than in the
placebo arm (54 %).
As expected,
at one - year follow - up, patients on the statin drug had lower cholesterol and triglyceride levels
than those on
placebo.
Also, there are alternatives that are better
than placebos and not deceptive
at all.
Researchers
at the Chemical Abuse Centers in Boardman, Ohio, found that combining magnesium oxide with the drug verapamil helped control manic symptoms in patients better
than a drug -
placebo combination.
To test the nasal vaccine in adults, researchers
at 13 hospitals nationwide, led by Kristin Nichol of the Veterans Affairs Medical Center in Minneapolis, gave it to more
than 2800 people in fall 1997; 1400 others got a
placebo.
The average spine BMD also increased more in the treatment group
than placebo group
at 12 months (3 percent vs. 1.1 percent) and
at 24 months (4.5 percent vs. 0.7 percent).
At a meeting of the American Society of Bone and Mineral Research last October, his team reported that girls receiving the upper dose in that trial grew more and denser bone
than did girls who got
placebo pills.
Both groups of participants assigned
at random to varenicline achieved significantly higher abstinence rates
at 12 weeks
than those assigned to
placebo, nicotine patch or bupropion.
One of these, a 2011 study led by psychiatrist Mark H. Rapaport, then
at Cedars - Sinai Hospital in Los Angeles, indicated that the plant was no more effective
than a
placebo for mild to moderate depression.
The team found that HRT was more effective
at this
than a
placebo, and seemed to have the most effect in women in the early stages of menopause, and those experiencing other life stresses.
For both trials, results
at the end of the first stage confirmed the phase 2 trials result — that adalimumab provided significantly greater symptom relief
than placebo, with no unexpected serious adverse events.
The IPERGAY researchers found that men who have sex with men and transgender women
at high risk for HIV infection who took PrEP around the time of sexual activity were 86 percent less likely to acquire HIV
than similar individuals who took a
placebo.
10 of 19 (53 %) placentas and 11 of 19 (58 %) fetal heads from mice who received Moderna's Zika mRNA vaccine had viral RNA levels
at the limit of detection of the assay, suggesting virtually complete protection, and the remainder had substantially lower levels
than those detected in samples from mice in the
placebo cohort.
In an open - label extension trial, or OLE, the volunteers from a blinded trial are invited to come back for further doses, and every volunteer gets the active drug rather
than some receiving drug and some the
placebo — usually
at the highest dose that was safely tried in the blinded trial.
A German study presented in July
at the International Congress on Obesity tested nine dietary supplements marketed for weight loss — including L - carnitine and polyglucosamine — and found that none worked any better
than placebos.
«There have been numerous studies of the HCG diet, all of which demonstrate that it works no better
than a
placebo,» says George Blackburn, MD, PhD, associate director of the Division of Nutrition
at Harvard Medical School.
In a recent Indiana University study, patients taking fish - oil supplements were better
at controlling exercise - triggered symptoms
than people taking a
placebo or just eating a normal diet were.
After three months, the LDL levels of those taking the active red yeast rice had declined 27 %, on average, compared to 6 % in the
placebo group;
at six months the decline in the active group was still more
than 21 %.
The researchers found that those who drank the Montmorency tart cherry juice in the morning and
at night were able to sleep more
than an hour longer each night (averaging 84 minutes) compared to the
placebo, and their sleep tended to be more efficient.
At the end of the intervention the rowers were 4.3 seconds faster
than the
placebo group in a 2,000 - meter race lasting over 6 minutes (22).
I think there's something there and I think maybe the best way to do it would be instead of looking
at just a
placebo, you'd almost have to go coffee versus coffee with fat to use your thing or just fat versus some form of
placebo rather
than just a fast, right?
of 22 studies found that subjects taking creatine averaged eight percent greater strength gains
than those on a
placebo, with an average 14 % increase in reps performed
at a given percentage of the lifters» maxes.
Similarly, a randomized, double - blind,
placebo - controlled study using a tea made from the traditional antispasmodic herbs chamomile, vervain, licorice, fennel and lemon balm was found to be more effective
at reducing crying time in colicky infants
than a
placebo.8 In this study, approximately half a cup of tea was given during each colic episode up to a maximum of three times per day.
In same study on 36 test subjects with
at least 3 years of weight training experience, subjects using the combination of creatine and whey gained 4 times the lean muscle
than those using a
placebo (8.8 vs. 2.0 lbs.).
People who ingested 900 mg of garlic powder daily had up to 18 % less arterial plaque
at the end of the study
than those taking a
placebo.
A meta - analysis of 34 double blind,
placebo - controlled, randomized studies that included 4,138 people, concluded that the probiotic strain, Lactobacillus rhamnosus GG, when given
at the same time as antibiotics, had a greater
than 60 % reduced risk of antibiotic - associated diarrhea.
Reported
at the International Congress on Obesity in Stockholm recently — a review of common «slimming supplements» versus
placebo, and not one worked better
than the sugar pills.
Subjects who were given the 300 mg / d CoQ10 supplement had a higher change in maximum velocity
at the start and finish of the trial
than the
placebo group.
No group [veggie, meat eater
placebo or creatine arm] did better in word recall
at the end of study
than at baseline!
In fact, in a 9 - week study conducted
at a leading university, subjects using the creatine in Six Star 100 % Creatine gained, on average, more lean muscle
than those using a
placebo (6 lbs.
At that rate I could hardly see much more
than a
placebo effect using Himalayan salt.
In
at least 12
placebo - controlled studies, children who were given different amounts of sugar reacted no differently
than those who had none, report Dr. Vreeman and Dr. Carroll.
In feeding studies, dogs fed these formulas performed better
at cognitive assessment tests
than dogs fed a
placebo diet.
Researchers for the American Chemical Society's weekly show, Reactions, took a look
at systemic reviews and found there is very little evidence that cough syrup is effective
at treating coughs, and that «carefully performed clinical trials show that these medications are generally no better
than a
placebo.»
The practice must have
at least one study utilizing some form of control (e.g., untreated group,
placebo group, matched wait list study) establishing the practice's benefit over the
placebo, or found it to be comparable to or better
than an appropriate comparison practice.