Dr Jones, said: «This new meta - analysis shows that baclofen is no more effective
than placebo on a range of key outcome measures, suggesting that the current increasing use of baclofen as a treatment for alcohol use disorders is premature.»
Not exact matches
Researchers report that bococizumab had short - term benefits
on lowering cholesterol levels and significantly reduced the risk of cardiovascular events by 21 percent compared to
placebo among those who had baseline LDL cholesterol levels of greater
than 100 mg / dL.
There was also less
than one additional case for every 1,000 women per year for heart disease and for stroke in the hormone - treated women compared with those
on placebo.
On average, individuals treated with liraglutide 3 mg lost 5.4 percent more of their body weight, achieving a total of 8 percent, and nearly 1.7 more inches (4.2 centimeters) around their waist
than did those who received
placebo, the investigators reported.
On November 8, Targacept, a drug company based in Winston - Salem, North Carolina, announced that TC - 5214 had performed no better
than placebo in one of four phase III trials.
But 2 years ago, the Women's Health Initiative reported that older women taking hormone supplements had more, not fewer, heart problems
than women
on placebo.
Women who were given testosterone but thought it was a
placebo,
on the other hand, offered fair - share splits 60 percent of the time — significantly more often
than those who correctly guessed they got testosterone (30 percent) or a
placebo (50 percent).
As expected, at one - year follow - up, patients
on the statin drug had lower cholesterol and triglyceride levels
than those
on placebo.
But his research over the years has soured him
on the drugs, suggesting they work only marginally better in the average patient
than a
placebo pill.
The trial found that
on a 13 - point scale, women who took the drug sold as Diclectin in Canada (Diclegis in the United States) reported symptom reductions that were 0.7 points greater
than women who took a
placebo.
Subjects were happier after winning a small reward while
on L - DOPA
than they were winning the same reward while
on a
placebo.
Participants who took the largest 10 - mg dose showed less decline
on one of two memory tests
than those receiving lower doses, or the
placebo.
The researchers obtained brain MRI scans
on participants before and after the study, and found that resveratrol - treated patients lost more brain volume
than the
placebo - treated group.
Power output
on the day participants consumed ketone salts was seven per cent lower
than on the day when they consumed the
placebo.
But a trial in which Kenyan women received a tenofovir pill daily was halted earlier this year after recipients seemed to be no better protected
than those
on placebos.
Belviq has also shown promise for people with type 2 diabetes, who were twice as likely to keep their blood sugars under control
than those
on the
placebo.
Parents
on lisdexamfetamine spoke less
than parents
on placebo during the homework task, with no differences during the non-academic task; they were less demanding
than parents
on placebo during the nonacademic task, with no differences during the homework task.
The results of the second phase showed that parents
on lisdexamfetamine made fewer commands, were more responsive to their child and praised their child more
than parents switched to
placebo.
During the non-academic component, parents were less likely to make negative statements toward their children
on lisdexamfetamine
than on placebo.
By week 48, participants had a 52 percent increase in dystrophin - positive muscle fibers and were able to walk 67.3 meters farther
than the
placebo group
on the six - minute walk test.
Mice with muscular dystrophy that received weekly prednisone were stronger and performed better
on the treadmill
than those getting a
placebo.
On the other hand,
placebos have a stronger effect in depressed patients
than in those with an anxiety disorder.
Two weeks after the rats sustained their injuries, Schwartz's group found that the number of surviving cells in the damaged nerves of these rats was three times higher
on average
than in rats with similar damage that received a
placebo injection.
Many of the trials are based
on small samples of patients, less
than 10 in each of the drug and
placebo groups.
By the end of treatment, the odds of experiencing a heavy drinking day in the
placebo group was five times more
than that of the topiramate group; and the number of patients who experienced no heavy drinking days
on the last four weeks of treatment in the topirmate group was more
than double that of the
placebo group.
On average, study participants who received GM - CSF had their maximum walking time increase almost a minute (53 seconds) more
than the
placebo group, although the difference was not statistically significant.
So, while the women
on placebo had lower quit rates
than men, the women taking naltrexone had quit rates similar to men.
Those studies really seek to make sure that the drug is safe, and if a drug passes that Phase I safety trial they move
on to a Phase II trial, where that drug is compared against a
placebo — so, no treatment or an existing drug to see if it performs as well or better
than the existing drug.
After 18 months, the men taking saw palmetto were doing no better
than those
on placebo, even though the dosage of saw palmetto was increased twice during the study, to 960 milligrams — three times the typical daily dose.
A German study presented in July at the International Congress
on Obesity tested nine dietary supplements marketed for weight loss — including L - carnitine and polyglucosamine — and found that none worked any better
than placebos.
«We can't show,
on the one hand, that it's better
than placebo, but some men do have an improvement in their symptoms, and there seem to be virtually no side effects,» he says.
What the research shows: A new review in The Journal of the American Medical Association showed that compared with a
placebo, people who took Qsymia lost up to 9.3 percent of their body weight in a year; those
on Belviq lost
on average about 3.2 percent over
placebo, while folks
on Xenical lost slightly less
than that.
A 2002 review of the research
on SAMe and depression conducted by the federal Agency for Healthcare Research and Quality concluded that SAMe was more effective
than placebo at relieving the symptoms of depression and no better or worse
than tricyclics.
Patients taking memantine continued to experience mental decline while
on the drug, but less so
than patients taking a
placebo.
In those studies, the percentage of people
on an atypical antipsychotic who gained a clinically significant amount of weight was between 2 and 10 times greater
than the comparable rate among people taking
placebo.
After three months, the LDL levels of those taking the active red yeast rice had declined 27 %,
on average, compared to 6 % in the
placebo group; at six months the decline in the active group was still more
than 21 %.
There are a ton of supplement companies out there, all promising the best product but the reality is that majority of supplements
on the market are little more
than overly processed
placebos.
Over the course of three months, patients treated with Aimovig experienced,
on average, 2 1/2 fewer monthly migraine days
than those receiving a
placebo.
The most recent Cochrane review
on cranberries, from 2012, analyzed two dozen trials involving 4,473 participants and concluded that cranberries are no more effective for preventing U.T.I.s
than placebos.
Conclusion: The average for the 4 relevant clinical studies
on humans showed weight loss of 3 pounds more
than placebo.
Creatine ethyl ester is a form of creatine that is supposed to be more bioavailable, but research shows it's less effective
than monohydrate,
on par with a
placebo.
Another massive review (22 studies) published in the Journal of Strength and Conditioning Research discovered that the average increase in muscle strength for subjects taking creatine while strength training was 8 % greater
than gains made
on placebo.
A new
placebo - controlled, blinded, crossover trial published in the American Journal of Clinical Nutrition shows that the phytonutrients in Montmorency tart cherries (Prunus cerasus) have a beneficial effect
on early hypertension, or blood pressure slightly higher
than the ideal 120/80 mmHg.
of 22 studies found that subjects taking creatine averaged eight percent greater strength gains
than those
on a
placebo, with an average 14 % increase in reps performed at a given percentage of the lifters» maxes.
While some review studies
on the substance indicate St. John's Wort is better
than a
placebo at treating mild to moderate depression with fewer side effects
than traditional antidepressants, other review studies have found no difference in effectiveness.
According to a study done
on elderly male and female patients ages 60 - 87,8 those given eight grams of spirulina per day for 16 consecutive weeks showed lower cholesterol levels
than those who were given a
placebo.
In same study
on 36 test subjects with at least 3 years of weight training experience, subjects using the combination of creatine and whey gained 4 times the lean muscle
than those using a
placebo (8.8 vs. 2.0 lbs.).
From the study, they found the subjects that took Hoodia consumed
on average 1,000 calories less
than the
placebo group, and found a statistically significant reduction in body fat.
In a recent trial for ulcerative colitis, a multicenter, randomized,
placebo - controlled, double - blind study found that more
than 50 percent of patients achieved remission within just one month
on curcumin compared to none of the patients who received the
placebo.
from 2014 found that basketball players maintained sprinting performance into the final quarter of their games better
on sodium bicarbonate
than a
placebo.