Sentences with phrase «than wild type mice»

A very neat paper shows that transgenic mice made to overexpress a certain hormone live much longer than wild type mice: The starvation hormone, fibroblast growth factor - 21, extends lifespan in mice.

«What we found was, if we block mGluR5, which is the glutamate receptor we're interested in, the mice become hyper locomotive so they become able to move better than wild type mice suggesting glutamate receptors might be a good target for treating movement disorders such as Parkinson's disease.

Not exact matches

As the mice aged, their motor performance on a rotarod test (which measures how long the mouse can remain on a rotating rod) became impaired and the length of their strides were significantly shorter than the wild type control mice.

These organoids had more stem cells than those isolated from wild - type mice.

Mice with two copies of this mutation (one on each chromosome) are white; those with just one copy are significantly lighter than wild - type mMice with two copies of this mutation (one on each chromosome) are white; those with just one copy are significantly lighter than wild - type micemice.

Several years ago, while creating a genetically engineered mouse that expresses high levels of the mouse HMGA1 gene to investigate its role in leukemia, Resar and her colleagues made the chance finding that the intestines of these animals were much larger and heavier than those of «wild - type» animals (or control mice that were not genetically modified).

Specifically, rod - mediated inner retinal responses to dim light flashes were faster in diseased mice than in their wild - type controls.

However, the magnitude of these behavioral responses in knockout mice was 40 % lower than in wild - type mice.

Overall, the cytochrome B knock - out strain is much less virulent, and mice infected with it survive much longer than those with the wild - type strain.

In addition, blood estrogen levels at late stages of pregnancy were found to be about two times higher in Nrk mutant mice than in wild - type mice, suggesting that Nrk is also involved in the regulation of synthesis or secretion of estrogen.

Acute alcohol - treated FOXO3 - deficient mice developed more severe liver injury than that of wild - type mice, and this was attributed to decreased expression of autophagy - related genes.

Also, mice that were bred to overexpress FGF21 consumed less alcohol than wild - type mice.

Obese mice deficient in TNF - α and iNOS are more sensitive to insulin than are obese wild - type mice (21, 29).

All clones with the wild type Tyr302, including the Envs from the viral innoculum and two Envs from X4 - ZFN mice utilized CXCR4 approximately 1000-fold more efficiently than CCR5 and comparably to the X4 - tropic control TYBE (Figure 6C).

Kaplan - Meier analysis demonstrated that most of the mice injected with cells expressing wild - type PREX2 or GFP exhibited tumor - free survival for more than ten weeks.

IL - 15Rα — KO mice also produced a greater number of wheel revolutions than wild - type C57BL / 6 mice, as depicted by the dashed line in Figure 3B.

As shown in Table 1, the presence of one or two Mstn mutant alleles in combination with the F66 transgene resulted in increasingly more muscle mass than seen in F66 transgenic mice that were wild type for Mstn.

Additionally, diabetic mice genetically modified to lack PKal showed far less retinal blood vessel leakage than wild - type mice.

In contrast, irradiated p21 - deficient mice survived longer than irradiated wild - type mice, and only one - third (32 %) of them developed tumors (Table 3 ⇓; Fig. 3 ⇓).

Indeed, other investigators have reported previously (32) that the radiation - toxicity syndrome is more severe in p21 - deficient mice than in wild - type mice, and it is associated to an enhanced apoptotic response of the intestine in p21 - null mice.

In Ames dwarrf, Snell Dwarf mice, Klotho mice, GHKO mice who have little IGF and GH; and live longer than wild - type; we see that indeed insulin and glucose / nutrient / energy pathways (which create oxidative stress through excessive nutrient via elevated glycation blood glucose creating high glycated albumin and hemoglobin), that aging is acted on by IGF through hormones, GFs, GHs, acting on insulin signals, which act on survival genes (DAF / SIRT / FOXO).

Mice lacking atg5, which is essential for autophagosome formation, have plasma amino acid levels that are 20 % lower than wild - type mice [2Mice lacking atg5, which is essential for autophagosome formation, have plasma amino acid levels that are 20 % lower than wild - type mice [2mice [211].

In a complementary approach to Thy1 labeling, Scart2 antibody treatment was found to label fewer Vγ4 + cells in LNs from Ccr6 - deficient mice than from wild - type mice (Figure 4I).

When homozygous C57BL / 6 - Fabp 4 - knockout mice (B6 - Fabp4 - / --RRB- are fed a high fat diet, they gain even more weight than wild - type B6 DIO mice.

Transgenic (Tg) mice overexpressing FGF21 are markedly smaller than wild - type mice and have a corresponding decrease in circulating IGF - 1 concentrations despite having elevated growth hormone (GH) levels....

GF mice raised in sterile incubators without any exposure to microbes are leaner than their wild - type, conventionally raised counterparts, despite consuming more food (1).

However, TPH2 − / − mice were not different from wild - type controls on any of these tests and in some cases were more resistant to the development of depression - like behaviors than wild - type controls.»