Sentences with phrase «therapeutic agents targeting»

Two new NSG mouse models allow immunological dissection of graft - versus - host disease (GVHD) responses and in vivo testing of therapeutic agents targeting human CD4 T cells.

Collagen Antibody Induced Arthritis (CAIA) is a simple mouse model of rheumatoid arthritis that can be used for the fast preclinical efficacy evaluation of candidate therapeutic agents targeting pathogenic mechanisms and inflammatory processes of arthritis.

OMP - 54F28 (FZD8 - Fc) and a sister compound also developed by OncoMed, vantictumab (OMP - 18R5), are two of the first therapeutic agents targeting this key pathway to enter clinical testing.

«It is possible that perhaps a therapeutic agent targeting BACE1 in humans might have a similar effect,» he says.

Not exact matches

Structure - based drug design, in which the physical structure of a targeted protein is used to help identify compounds that will interact with it, has already been used to generate therapeutic agents for a number of infectious and metabolic diseases.

«Our findings suggest that PRMT5 is a possible prognostic factor and therapeutic target for glioblastoma, and they provide a rationale for developing agents that target PRMT5 in this deadly disease,» says co-corresponding author Robert A. Baiocchi, MD, PhD, associate professor of medicine and a hematologist at the OSUCCC — James who is also collaborating on an Ohio State effort to develop a PMRT5 inhibitor.

Dr. Dong said the findings have significant implications in the prevention and treatment of type 2 diabetes and could prove to be useful targets for modulation of insulin sensitivity and glucose homeostasis and as a target for therapeutic agents to increase liver function to prevent diabetes.

A team led by Fengzhi Li, PhD, and Xinjiang Wang, PhD, of Roswell Park Cancer Institute (RPCI) has reported new findings regarding therapeutic targets of the novel anticancer agent FL118.

This work raises the possibility of developing new therapeutic agents that target the X protein and prevent the virus escaping from liver cell defences.

«Together, our findings indicate that these molecular regulators, TRIP - Br2 and GATA3, could be viable targets for small drug molecules that could serve as potential therapeutic agents against obesity,» Liew said.

«New insights into the biology of heart failure are desperately needed to prompt new types of targeted therapeutic agents,» says senior study author James Bradner of the Dana - Farber Cancer Institute and Harvard Medical School.

Houston Methodist researchers have built disc - shaped nanoparticles to deliver imaging or therapeutic agents to targeted cell types.

Early - phase data on larotrectinib validate TRK fusions as therapeutic targets and show they lead to tumor - agnostic sensitivity to this agent.

In other words, Ras proteins naturally lack areas that are accessible, high - affinity binding targets for potential therapeutic agents.

The Vanderbilt findings provide «proof - of - concept that targeting an antitumor agent to an intracellular protein may increase antitumor selectivity and improve the therapeutic window for treating naturally occurring cancers,» said first author Jashim Uddin, Ph.D., research associate professor of Biochemistry.

Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma

«As more of the pieces are assembled, they provide potential new targets for therapeutic agents.»

Targeted therapy will be the way to provide personalised treatment, by selecting therapeutic agents according to a target that has been identified on the patient's own tumour.

It is unlikely that one  therapeutic agent will be able to target the cancer stem cells in for example all types brain tumors.

Since the discovery that telomerase is repressed in most normal human somatic cells but strongly expressed in most human tumors, telomerase has become a target for therapeutic agents to combat human cancer.

Details regarding the nature of these pathways are still being investigated, although interventions targeting these mechanisms have therapeutic potential, as already seen with thiazolidinediones, agents that increase insulin sensitivity and decrease muscle and hepatic triglyceride load (16).