Sentences with phrase «therapeutic antibody»

NSCs are also able to cross the BBB, making them a potential platform for therapeutic antibody delivery to the brain.

BIIB054 was originally developed by biotech company Neurimmune, using a platform they call Reverse Translational Medicine (RTM ®), which derives therapeutic antibody candidates from libraries of de-identified B - cells isolated from ostensibly healthy older adults (those free of specific neurological diseases of aging).

Dr. van de Winkel has over 25 years of experience in the therapeutic antibody field and served as Vice President and Scientific Director of Medarex Europe prior to Genmab.

This enables therapeutic antibody drugs to bind with extreme precision — only their target molecule should be an exact match.

«But at the same time, we are also developing a therapeutic antibody targeting annexin A2, and we are looking for a small molecule that would inhibit Sema3D.»

In collaboration with the Vall Hebrón Oncology Institute (VHIO), they are now focusing on binding a peptide to a therapeutic antibody to treat glioblastoma — the most aggressive brain cancer in adults.

Leveraging its pioneering monoclonal antibody technologies, Alder discovers and develops novel therapeutic antibodies designed to deliver highly differentiated, best - in - class clinical profiles.

She will be using therapeutic antibodies to dampen the inflammation around ovarian tumors.

In treating chronic diseases like rheumatism or Crohn's disease, such therapeutic antibodies are used as medication.

One of the potential applications of this system is to measure the quantity of therapeutic antibodies in the blood and decide whether it is necessary to administer any extra medication.

Now, Thomas Weimbs, a professor in UC Santa Barbara's Department of Molecular, Cellular, and Developmental Biology, has developed a novel strategy for targeting therapeutic antibodies to polycystic kidneys.

Therapeutic antibodies — a class of biologics — are already being used extensively to treat a variety of diseases from cancer to autoimmune disorders.

One approach to tackle this challenge is to program into the therapeutic antibodies the capability of binding to receptors that can help the MAbs to cross into the brain.

The company was largely focussed on the generation of proteins, including therapeutic antibodies, in potato plants.

It's a long way from mice to humans, and the cost of producing therapeutic antibodies may be prohibitive.

Since then, Lerner and his colleagues have used these techniques to discover a number of therapeutic antibodies, including the anti-inflammatory antibody Humira ®, now one of the world's top - selling drugs.

CRI presents the Coley Award to Jeffrey V. Ravetch for his work on Fc receptors, leading to fundamental discoveries critical to improving the design of therapeutic antibodies.

iTeos and Adimab LLC are collaborating on the discovery, development and commercialization of multiple, antibody - based therapeutic programs, with Adimab using its antibody discovery and optimization platform to identify fully human therapeutic antibodies against targets selected by iTeos.

This new knowledge framework can e.g. be used to improve genetic libraries for the making recombinant therapeutic antibodies.

One secondary outcome will be immunogenicity, meaning monitoring subjects for any emergence of antibodies against the infused therapeutic antibodies themselves; additionally, «Multiple clinical and exploratory biomarkers will be assessed» in the Phase Ib trial.

In fact, the FDA has recommended that newer technologies be employed as soon they become available, to reduce the possibility of very serious off - target effects of therapeutic antibodies that bind to antigens in non-target tissues.

Data from a new study on how antibodies are developed in humans can be utilized to improve the development of therapeutic antibodies for treating human diseases.

Dr. Economides co-invented Cytokine Traps, VelociGene ®, and VelocImmune ®, all part of an integrated methodology for target discovery, validation, and the generation of biologic drugs such as the IL1 and VEGF traps, as well as therapeutic antibodies.

This platform has enabled the Company and its collaboration partners to discover and develop high - quality therapeutic antibodies against a variety of molecular targets, including targets that are difficult to drug with conventional antibody technologies.

Citation: Frank RT, Edmiston M, Kendall SE, Najbauer J, Cheung C - W, Kassa T, et al. (2009) Neural Stem Cells as a Novel Platform for Tumor - Specific Delivery of Therapeutic Antibodies.

The IME Molecular Biology Division has a long standing expertise in the expression of recombinant proteins like therapeutic antibodies and vaccines using different transient and stable plant - based systems.

The IME Molecular Biology Division has a long standing expertise in the expression of recombinant proteins like therapeutic antibodies and vaccines using different expression platforms.

The partnership will use the Human Emulation System — a lab - ready system comprised of Organ - Chips, instrumentation, and software apps — to discover and develop new classes of therapeutic antibodies and drug combinations, many of which have complexities and human - specific features.

Therefore, we examined the feasibility of expressing therapeutic antibodies in tumor - tropic human NSCs, with the ultimate goal of using such NSCs as a platform for delivery of anti-HER2 antibody to otherwise inaccessible tumor foci.

The partnership is designed to use Organ - Chips that reflect the complex biology required to model the effects of therapeutic antibodies in humans, overcoming the limitations of current preclinical experimental methods.

We conclude that tumor - tropic human NSCs can be genetically modified to secrete intact therapeutic antibodies.

Not exact matches

Schering - Plough, for example, merged two of its California research facilities in 2005 to create a new unit in Palo Alto that focuses on monoclonal antibodies and other therapeutic proteins.

I applied and was awarded an OIF to investigate whether dendritic - cell - specific antibodies can be used as therapeutic options for GVHD.

We demonstrated that DENV serotype 2 (DENV2)-- specific human monoclonal antibody (HMAb) 2D22 is therapeutic in a mouse model of antibody - enhanced severe dengue disease.

This information leads us to believe that these sites are under «selection pressure» by the therapeutic, meaning that the antibody cocktail binds and promotes elimination of the original virus, while the escape variants continue the infection.»

Moreover, companies are moving into the use of new types of therapeutic proteins such as antibodies, which are only effective at high doses.

Within a company, you're likely to specialize, since most companies are focused on a narrow area of science (i.e., therapeutic human monoclonal antibodies).

In the past, scientists have tried to determine therapeutic effectiveness by separating patients into groups based on their clinical parameters such as what antibodies they are producing against themselves, how swollen their joints are and medications they are taking.

Reporting their study data Sept. 22 in the journal Immunity, scientists at Cincinnati Children's Hospital Medical Center say their findings in mice should also provide insights into new therapeutic strategies and diagnostics for food allergies and anaphylactic shock triggered by the immune antibody IgE (immunoglobulin E).

Antibodies that target PD - L1 or its receptor PD - 1 have shown remarkable therapeutic effects for many cancer patients, sometimes even for those who are terminally ill.

Performance and specificity are critical for antibodies to be used effectively in research, diagnostic, and therapeutic applications, yet reagents to validate antibody specificity are currently lacking.

Soon, the team hopes to see the antibody therapeutic go into clinical trials.

«This is the first antibody therapeutic found that could treat Marburg,» says Erica Ollmann Saphire, PhD, a TSRI professor and senior author of the study, published today in the journal Cell Host & Microbe.

As a further therapeutic option, the researchers are pursuing the approach of using specifically developed antibodies against CEACAMs in order to fight diseases associated with the bacterium.

The researchers hope their study will lead to better therapies for neurodegenerative disorders, as well as help clinicians avoid the possible dangerous side - effects of using anti-prion protein antibodies for therapeutic purposes.

As many in the industry point out, monoclonal antibodies have become a hugely lucrative and important therapeutic class — but their development was just as fraught, with just as many hurdles, as RNAi.

The inflammation parameters in the transplanted kidneys decreased significantly and renal function in all recipients is excellent,» summarises Marcus Groettrup, adding that these results suggest immunoproteasome inhibition as a promising therapeutic approach to suppress chronic antibody - mediated rejection.

The study, published in Cell, suggests these antibodies could limit immune - related diseases and may have therapeutic potential.

This therapeutic effect was enhanced by combining the Angiopoietin - 2 antibody with a so - called metronomic chemotherapy: In this kind of therapy, chemotherapeutic drugs are given continuously at much lower dose as in the classical high - dose chemotherapy.

«Targeting this inflammatory pathway with drugs or antibodies could be a new therapeutic strategy to treat worm infections and the associated pathology,» said Meera Nair, an assistant professor of biomedical sciences in the UC Riverside School of Medicine, whose laboratory made the discovery.