Sentences with phrase «therapeutic cell treatments»

The one developed by Zhang and his team, including Ph.D. student Inga Haedicke, U of T Assistant Professor Hai - Ling Margaret Cheng and two research groups (Dr. Timothy Scholl and Dr. Paula Foster) from Western University, can improve monitoring at the cellular level, which is a crucial element in measuring the effectiveness of stem and therapeutic cell treatments.

Not exact matches

«Therefore, the targeting of Runx2 expression in multiple myeloma cells may represent a new therapeutic strategy for the treatment of aggressive multiple myeloma.»

Specific immune cells have the ability to produce a healing factor that can promote wound repair in the intestine, a finding that could lead to new, potential therapeutic treatments for inflammatory bowel disease (IBD), according to a new research study.

The estimation of EGFR mutation status is essential for the identification of non-small cell lung carcinoma (NSCLC) patients who may benefit from treatment with EGFR tyrosine kinase inhibitors (TKIs), and hence for improving therapeutic efficacy.

Scientists are hopeful that ultimately these cells could be transformed in the laboratory to yield specific cell types needed for a particular treatment, or to cross the «blood - brain barrier» by expressing specific therapeutic agents that are released directly into the brain.

Therefore, chloroquine can nip the metastatic spreading of cancer cells in the bud, which is the most important therapeutic goal in any tumor treatment.»

Because the different cancer cells within a tumorous tissue also develop different modes of defense against therapeutic measures, the treatment of patients is extraordinarily difficult.

In the study published in the journal Science Signaling, the team led by LLuís Espinosa, investigator of IMIM's research group into stem cells and cancer, have shown that inhibition of endosomal activity is a potential therapeutic strategy for the treatment of cancers with the BRAF mutated gene.

That doesn't mean patients should stop treatment, caution the authors, who call these robust survivor cells a new therapeutic target.

While still early in development, stem and therapeutic cells may one day offer effective treatments against diseases, particularly cancer.

Stem Cell Treatments Due to the ability of adult stem cells to be harvested from the patient, their therapeutic potential is the focus of much research.

While a Jane Coffin Childs Postdoctoral Fellow in Wendell Lim's laboratory at UCSF, he developed a new class of synthetic receptors, which provide unprecedented customization of therapeutic cells for treatment of a broad range of diseases.

Attacking the perennial problem of systemic toxicity from typical chemotherapy treatments, Dartmouth investigators, led by Barjor Gimi, PhD, have engineered therapeutic cells encapsulated in nanoporous capsules to secrete antitumor molecules from within the tumor.

Interestingly, the team showed that combining anti-angiogenic and immune - stimulating therapies in the treatment of tumors in mouse models resulted in better therapeutic outcomes by providing white blood cell gates through which they can infiltrate cancers.

Allender and former veterinary student Lauren Kane demonstrated, however, that administering treatments via a fine spray allows therapeutic levels of terbinafine, an antifungal agent that kills O. ophiodiicola in cell culture, to get into healthy snakes» blood plasma.

A closer examination of the data found that the animal had more HCV - specific T cells in the liver before therapy, which could mean that therapeutic success hinges on the amount of HCV - specific T cells in the liver before treatment.

This is the first evidence that starvation of endothelial cells could offer new therapeutic opportunities for the treatment of excessive angiogenesis in diseases (like cancer).

Specifically, they want to know what role the quality of T - cell immunity before treatment plays in therapeutic response.

C. Develop ways to overcome cancer's resistance to therapy Identify therapeutic targets to overcome drug resistance through studies that determine the mechanisms that lead cancer cells to become resistant to previously effective treatments.

Several tests in cultured cells indicated that ganciclovir would cause the death of HSV - TK - expressing stem cells, and testing in the mouse model confirmed that administration of the drug after successful treatment of brain metastases successfully eliminated therapeutic stem cells that also expressed HSV - TK.

Dr. Kulkarni's research focuses on investigating signaling pathways impacting growth and function of pancreatic islet cells with the long - term goal of improving therapeutic approaches for the treatment of type 1 and type 2 diabetes and obesity - associated conditions.

Asked, for instance, whether adult or embryonic stem cell research had yielded any therapeutic results, only 23 % of respondents answered correctly that, to date, only adult stem cells have resulted in treatments for disease.

Therapeutic applications of CRISPR - Cas gene editing are being advanced with the goals of finding cures and treatments for a range of serious diseases, developing needed medicines for both household pets and production animals, and improving cell culture systems for bioproduction.

Producing cell - based treatments entails substantial hands - on manipulation and perfecting the logistics of harvesting and expanding therapeutic cells and delivering them to patients.

As a result, they are currently being investigated as a cellular therapeutic for the treatment of autoimmune diseases and long - term patient and graft survival following solid organ transplantation, and allogeneic hematopoietic stem cell transplantation.

We are now beginning to recognize that paracrine effects represent the primary driving therapeutic force behind mesenchymal stem cell (MSC)- based treatments.

Clinical studies have assessed have assessed fetal tissues as a therapeutic treatment for HD [2 - 4], although these present with problems which may be overcome by the use of induced pluripotent stem cells (iPSCs)[5].

With this backdrop of «stem cell treatments as here and ready use,» people, when faced with an incurable condition with no therapeutic solutions, turn to stem cell research - which appears to be offering all the solutions.

This new knowledge has paved the way for the therapeutic transfer of stem cells not only for the treatment of hematopoietic diseases by bone marrow transplantation â $» first attempted by E. Donnall Thomas, one of this bookâ $ ™ s editors, in 1957 â $» but also for the treatment of many other disorders.

This is in addition to the licensing of products such as GlaxoSmithKline's Strimvelis ex-vivo stem - cell therapy for treatment of severe combined immunodeficiency caused by adenosine deaminase deficiency (ADA - SCID) in 2016 (1)-- has led to an increase in demand for therapeutic vector manufacturing capabilities.

The patented discovery comes from Novocell's recognized research & development programs to commercialize pluripotent stem cells for broad research and therapeutic uses, in particular, for an innovative cell therapy for the treatment of diabetes.

Our findings open the way to develop therapeutic strategies to remove lipofuscin from RPE cells, which may have implications for the treatment of age - related macular degeneration in which lipofuscin accumulation in cells is a causative factor.

to provide treatments to delay / stop cell death and expand the therapeutic window for genetic interventions.

The comprehensive information presented for each cell therapy includes: an overview of the therapy, a list of therapeutic cells utilized in the specific treatment, mode and regimen of cell delivery, mechanism of action, formulation, in vitro data, animal models, preclinical data and related clinical trials.

A major impetus to the field was the report of a successful cure strategy through the transplantation of naturally HIV - resistant HSPCs - the so called «Berlin Patient» [3, 4]- highlighting the therapeutic potential of stem cell treatments.

However, current results point to a possible role for hNPCctx in the treatment of at least some forms of human retinal degenerative diseases and highlight the versatility and efficacy of these cells as therapeutic tools in a broad range of neurodegenerative disorders [10]--[12], [66].

These treatments can be broken into 5 main categories: checkpoint inhibitors / immune modulators, adoptive cell transfer, monoclonal antibodies, therapeutic vaccines, and cytokines.

The therapeutic or treatment vaccine Axalimogene Filolisbac, which is given intravenously, makes use of the ability of the Listeria bacteria to infect cells.

Because they suppress cell division, paclitaxel and other taxanes are important therapeutic compounds for the treatment of cancer and other the diseases.

Studies using a mouse model of type 1 diabetes highlight a potential role for human adipose stem cells in treatment regimens and, further, they reveal a secreted factor which has important therapeutic relevance

SAN DIEGO, March 28, 2017 (GLOBE NEWSWIRE)-- Invivoscribe ® Technologies Inc., a global company with decades of experience providing internationally standardized clonality and biomarker testing solutions for the fields of oncology, personalized molecular diagnostics ®, and personalized molecular medicine ®, reports that its next - generation sequencing (NGS) LymphoTrack ® Assay kits are being used by its LabPMM ® clinical laboratories, pharmaceutical partners, and cancer centers to identify and monitor chimeric antigen receptor T - cells (CAR - T) and engineered T - cell receptors in peripheral blood of subjects in support of immuno - therapeutic drug development and treatment regimen development for both hematologic and solid tumors.

The next, therapeutic, stage of PNB treatment was realized by increasing the energy of the pump laser pulses to the level that provided the PNB lifetime well above cell damage level (i.e. longer than 100 ns).

Currently available treatments including hydroxyurea, which is the only FDA approved drug for SCA, and hemopoietic stem cell transplantation all have significant limitations, so the search for new therapeutic options continues.

The project «Preprogrammed versus stochastic clonal evolution of relapsing Acute Myeloid Leukaemia: Impact on disease development and therapeutic responses» will dissect why the subpopulations of primary human blood cancer cells that drive leukaemic relapse resist relevant clinical treatments in vivo.

Myelosuppression is a well - established side effect of current AML therapies, with prolonged events leading to an increased risk of infections and death.44 Consequently, therapies that preferentially kill leukemic cells over normal bone marrow cells are urgently required, and the overexpression of CD123 on AML leukemic stem cells and blasts compared with normal hematopoietic cells contributes to its attractiveness as a therapeutic target in this disease.6, 45 However, severe myelosuppression and myeloablation have emerged for some investigational CD123 - targeted treatment modalities.

This study just found (in mice) that the common therapeutic target for the anti-TNF medication treatment of IBD, may actually protect against intestinal inflammation by inhibiting pathogenic T - cells.

Pluristem Therapeutic is a bio-therapeutics Company dedicated to the commercialization of non-personalized cell therapy products for the treatment of several severe degenerative, ischemic and autoimmune disorders.

Also, a patient's own stem cells, therapeutic laser, joint injections and nutritional supplements can be extremely beneficial in the treatment of acute and chronic pain.

Which therapeutic regimen to choose depends partly on the number of functionally active beta cells in the pancreas and, of course, on the response of individual dogs to treatment.

We offer traditional medical and surgical services as well as animal spinal adjustment, therapeutic laser treatments, stem cell therapy, acupuncture and Chinese herbal medicine.