Sentences with phrase «therapeutic development for»

A striking example of the use of LoF alleles to guide therapeutic development for CHD is PCSK9, for which LoF mutations were associated with low levels of LDL cholesterol and protection from CHD; this led to the development of PCSK9 inhibitors.

Learn from our patients some fundamental truths about epigenetics with the hope that this additional knowledge will lead to therapeutic development for our patients in the future.

These results not only change our fundamental understanding of what exactly goes wrong in the muscles of Duchenne muscular dystrophy patients, but they argue for a very different approach to therapeutic development for this devastating disease.»

«Biomarkers are critical to accelerating therapeutic development for any disease.

Objective: To provide data - driven and computational infrastructures and data - sharing platforms to support large - scale, system - level data integration and modeling, and enable predictive biology for pathogens and host - pathogen interactions for discovery research, clinical investigation, and therapeutic development for infectious diseases.

«It will [also] have important connections to future therapeutic development for other severe disorders of consciousness,» said company founder Dr. Sergei Paylian.

Supports work that can accelerate neurotrophic factor therapeutic development for Parkinson's Disease.

Supports work that can accelerate neurotrophic factor therapeutic development for Parkinson's disease (PD).

For decades, the Tourette Association of America has led the way in research and therapeutic development for Tourette Syndrome and other Tic Disorders, and has provided more than $ 20 million in grants to fund research and develop medical programs that meet the needs of those affected by Tourette.

Not exact matches

Forward - Looking Statements This press release contains forward - looking statements, including, without limitation, statements relating to: the continued build - out of Alder's executive team; Alder's growth and development; the role of Alder's Chief Operating Officer; the continued development and clinical, therapeutic and commercial potential of eptinezumab; the opportunity of eptinezumab to transform treatment for migraine patients; and the anticipated commercialization of eptinezumab.

Actual results and the timing of events could differ materially from those anticipated in the forward - looking statements due to these risks and uncertainties as well as other factors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sec.gov.

Mannkind, which focuses on the development and commercialization of inhaled therapeutic products for patients with diseases such as diabetes and pulmonary arterial hypertension, entered a shallow but persistent downtrend in 2004, posting a series of lower highs into 2015.

But the last biting incident he had at school set into motion a chain of events that led us to a great child development specialist, who sent us to a kick - ass occupational therapist and also helped us find a therapeutic aide for him in the classroom.

Our stockings provide therapeutic care for your feet, while preventing the development of serious vascular conditions.

She received her training as an Early Childhood Development Specialist at the Thalian Mental Health Center at Cedars - Sinai Hospital and the Cheerful Helpers Therapeutic Pre-School and in 1977 became a group leader for ECPC.

Athletic Trainers work closely with physicians and other health professionals and are responsible for being current in several areas, including: an evidence based practice (EBP), prevention and health promotion (PHP), clinical examination and diagnosis (CE), acute care of injuries and illnesses (AC), therapeutic interventions (TI), psychosocial strategies and referral (PS), healthcare administration (HA), and professional development and responsibility (PD).

We offer a number of therapeutic services for children from one year of age through adolescence that include individualized speech and language therapy, parent training to facilitate language development in children who are late talkers or stuttering, and interventions to facilitate social communication and pragmatics.

Thus, although improving the economic status of families promotes more positive outcomes for children's cognitive development and academic achievement, direct services and therapeutic interventions may be a comparatively more promising alternative for improving children's psychosocial development and reducing behaviour problems.

It also can keep out therapeutic drugs and, when defective, biomolecules that are needed for healthy brain development.

These findings offer a promising potential for using those probiotic species for preventative and therapeutic treatment development.

Of approximately 300 staff at the Center for Therapeutic Research, only nine postdocs and students are conducting basic research; the rest work in drug discovery and development.

For decades there has been some belief that pregnancy has an adverse effect on the course of melanoma, increasing the risk of its development, ability to spread throughout the body, and recurrence, said study coauthor Mark Faries, MD, FACS, who was director of therapeutic immunology at the John Wayne Cancer Institute, Santa Monica, Calif. at the time the study was conducted.

«Knowing the genetic basis for these types of problem will permit development of diagnostic tests and ultimately therapeutic interventions,» says co-author Laurent Fasano, also from CNRS.

«This work represents a mechanistic insight that could lead to the development of a new therapeutic approach for preventing asthma.»

This study is among several funded under a public - private partnership established in 2008 between NICHD and the WALTHAM Centre for Pet Nutrition, a division of Mars Inc., to establish a human - animal interaction research program to support studies relevant to child development, health, and the therapeutic use of animals.

There are currently 300 therapeutic proteins in the biopharmaceutical industry's development pipeline, while those already on the market will soon be out of patent and ripe for exploitation as generics.

The next objective of the researchers is to decode the action mechanism of TREX2 in the development and maintenance of psoriasis, so as to design new therapeutic strategies for the treatment of this disease.

As a result, the emphasis in early development is on understanding the molecular underpinnings of disease and developing markers for therapeutic effects.

Determining the detailed molecular mechanism that mediates the therapeutic actions of cannabidiol may suggest development strategies for new drugs aimed at GPR55, according to the researchers.

«Using approved therapies for one condition to treat another, or drug repurposing, offers new avenues to speed Parkinson's therapeutic development,» said Dr Brian Fiske, senior vice president of research programs at MJFF.

«We are excited by the work of Dr. Pourdehnad and colleagues and believe these results are an important advance in understanding the role of myc pathway dysregulation in multiple myeloma, and ultimately allow for the development of therapeutic strategies to address it,» said Jeffrey Wolf, MD, a UCSF blood disorder specialist and director of the Stephen and Nancy Grand Multiple Myeloma Translational Initiative at UCSF, a sponsor of the research.

The work demonstrates that BRAF - mutated melanoma requires autophagy for tumor development and blocking autophagy could have therapeutic value, particularly in combination with BRAF inhibition.

Dr. Paul R. Sanberg, Distinguished University Professor, a co-author of the paper, concluded that «these novel data showing BSCB damage in subacute and chronic ischemic stroke may lead to development of new therapeutic approaches for patients with ischemic cerebral infarction.»

This pathway may serve as a target for the development of an effective therapeutic.

To strengthen its clinical research profile, Dresden has created a strategic plan, to be funded by the German Research Ministry (BMBF), that focuses on three aspects of clinical research: tissue engineering and development of physical and molecular medical technologies for clinical application; therapeutic strategies after cell and tissue damage; and diagnosis and therapy of malignant diseases.

«This latest finding provides a concise and direct synthesis pathway that, due to the structure of the products delivered, will likely be quite valuable for the discovery and development of therapeutic agents,» says Micalizio, whose work focuses on the design of organic chemical reaction methods and strategies to improve medicine and human health.

Co-lead author, Doctor Mohammed Eslam, said this discovery holds great promise for the development of effective therapeutic treatments for liver disease.

«A significant amount of work remains in the development of teixobactin as a therapeutic antibiotic for human use — we are probably around six to ten years off a drug that doctors can prescribe to patients — but this is a real step in the right direction and now opens the door for improving our in vivo analogues.»

Professor Fallon said: «This identification of an early stage cellular checkpoint that can act as a break on allergic responses has important implications for the development of new therapeutic approaches for asthma and other allergic diseases.»

«This makes it important to identify new therapeutic targets for the development of effective treatments,» the investigators conclude.

«These results are particularly exciting because they suggest that drugs directed at fusion - circular RNAs could be a powerful strategy to pursue for future therapeutic development in cancer,» said Pandolfi.

The role of Apelin and Elabela in establishing the circulatory system makes them potential targets in future development of therapeutic applications for illnesses ranging from the various cancers, and cardiovascular diseases, to even metabolic diseases such as diabetes.

His research focuses predominantly on oncology molecular diagnostics, particularly the source and utility of miRNA biomarkers in blood, and the development of innovative molecular diagnostics for the identification of mutations that can guide therapeutic decision - making.

This microRNA — miR -124-3p — is thus a potential therapeutic target for novel drug development, and it can serve as a putative biomarker for MDD pathogenesis.

«Network model of the musculoskeletal system predicts compensatory injuries: The authors» simplified musculoskeletal model could lead to clinical developments for testing therapeutic responses to injury.»

The Myelin Repair Foundation, which funded this work as part of a multi-institutional effort to accelerate research and development of treatments for MS, has entered into a cooperative agreement with the National Institutes of Health to assess guanabenz as a therapeutic candidate in MS clinical studies.

Compelling infographics round out this robust examination, illustrating data sets on the costs of developing drugs, the major shifts in global demographics and patient needs, the explosions of data that must be mined for future therapeutic development, and the health spending of a wide variety of nations.

Like other big pharma companies, Pfizer is partnering with academic institutions to share the risk of drug development and take advantage of academic scientists» broad base of knowledge, says Boston - based Anthony Coyle, vice president of the Centers for Therapeutic Innovation (CTI) at Pfizer.

Now, researchers may finally understand an important mechanism that keeps this friendly truce intact — a finding that may lead to the development of new therapeutic strategies for such chronic diseases.

Natural killer cells serve important roles in clearing non-type 2 inflammatory cells, so identification of a defect in NK cell function in severe asthma provides a window for the development of new therapeutic approaches.