Sentences with phrase «therapeutic development in»
These recently published findings may offer scientists a new target for therapeutic development in HD.
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«The dBET1 and the dFKBP12 compounds are presently in a late stage of lead optimization for therapeutic development in both cancer and non-malignant diseases,» says Prem Das, PhD, chief research business development officer at Dana - Farber.
«These results are particularly exciting because they suggest that drugs directed at fusion - circular RNAs could be a powerful strategy to pursue for future therapeutic development in cancer,» said Pandolfi.
Not exact matches
Actual results and the timing of events could differ materially from those anticipated in the forward - looking statements due to these risks and uncertainties as well as other factors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sec.gov.
IONIS» FORWARD - LOOKING STATEMENT This press release includes forward - looking statements regarding Ionis Pharmaceuticals» business and the therapeutic and commercial potential of Ionis» technologies and products in development, including SPINRAZA, inotersen and volanesorsen.
Amarin's product development program leverages its extensive experience in lipid science and the potential therapeutic benefits of polyunsaturated fatty acids.
Mannkind, which focuses on the development and commercialization of inhaled therapeutic products for patients with diseases such as diabetes and pulmonary arterial hypertension, entered a shallow but persistent downtrend in 2004, posting a series of lower highs into 2015.
Joining forces with Pfizer matches our leading products in seven high growth therapeutic areas and our robust R&D pipeline with Pfizer's leading innovative and established businesses, vast global footprint and strength in discovery and development research to create a new biopharma leader.»
The curriculum should be evaluated and revised in terms of its effectiveness in preparing the students to become facilitators of growth and healing, and of the development of therapeutic - redemptive communities in the churches.
This makes possible the fuller development of new theories informed at once by Whitehead's cosmology and by immersion in therapeutic practice.
Recent developments in «milieu therapy» and the «therapeutic community» approach indicate that therapeutic goals can be achieved in much larger groups than had been thought possible in orthodox group therapy theory.
Self - help groups (many of which are modeled on Alcoholics Anonymous) represent one of the most hopeful developments in the whole field of contemporary therapeutic groups.
One of the serendipities modern readers find in studying Gregory is that he seems to anticipate several psychological approaches and therapeutic developments that are currently considered to be wholly unprecedented innovations of contemporary psychotherapy.
Hall characterizes this turn in various ways: as a shift in emphasis from «external technologies» to «internal technologies aimed at self - creativity» (UP 395; cf. 318 - 47), as the development of a «therapeutic society containing a plurality of techniques and practical reason in an aesthetic methodology» (UP 242).
But the last biting incident he had at school set into motion a chain of events that led us to a great child development specialist, who sent us to a kick - ass occupational therapist and also helped us find a therapeutic aide for him in the classroom.
This weekend I had the opportunity to further my professional development by obtaining training in a therapeutic program I've been wanting to use since before I was a therapist: THERAPEUTIC Ltherapeutic program I've been wanting to use since before I was a therapist: THERAPEUTIC LTHERAPEUTIC LISTENING ®.
Chris Sekely CWS Kindergarten teacher since 1996 Penn State University, BS in Human Development University of Pittsburgh, MS in Public Health Antioch College, MEd Waldorf Certification & Gradalis Therapeutic Certification Returning Board Member in 2016 Connie Davis CWS Class teacher since 2003 University of the South, BA English Literature 1985 Manufacturing Management 1986 - 1998 Antioch University, Waldorf Teacher Certification 2008 CWS Faculty Chair 2007 CWS Grades Chair 2012 CWS College Chair 2017 Returning Board Member 2017
Vocabulary development, rehearsal, and practice of using language in social situations are often helpful therapeutic methods.
Therapeutic interventions are child - led and child - oriented in nature as well as take account of a child's holistic development and well - being.
She received her training as an Early Childhood Development Specialist at the Thalian Mental Health Center at Cedars - Sinai Hospital and the Cheerful Helpers Therapeutic Pre-School and in 1977 became a group leader for ECPC.
Athletic Trainers work closely with physicians and other health professionals and are responsible for being current in several areas, including: an evidence based practice (EBP), prevention and health promotion (PHP), clinical examination and diagnosis (CE), acute care of injuries and illnesses (AC), therapeutic interventions (TI), psychosocial strategies and referral (PS), healthcare administration (HA), and professional development and responsibility (PD).
We offer a number of therapeutic services for children from one year of age through adolescence that include individualized speech and language therapy, parent training to facilitate language development in children who are late talkers or stuttering, and interventions to facilitate social communication and pragmatics.
In addition, risks associated with the usability, therapeutic efficacy and market share of medicinal substances are usually realized only in the final stages of drug developmenIn addition, risks associated with the usability, therapeutic efficacy and market share of medicinal substances are usually realized only in the final stages of drug developmenin the final stages of drug development.
Of approximately 300 staff at the Center for Therapeutic Research, only nine postdocs and students are conducting basic research; the rest work in drug discovery and development.
Richard Hargreaves, executive director of imaging at Merck Research Laboratories, says, «Nuclear imaging using radiotracers gives the opportunity to put your arms around proof - of - concept very early in a drug discovery and development program by focusing the selection of doses to study on those proven to deliver enough drug to the target therapeutic sites.»
This study is among several funded under a public - private partnership established in 2008 between NICHD and the WALTHAM Centre for Pet Nutrition, a division of Mars Inc., to establish a human - animal interaction research program to support studies relevant to child development, health, and the therapeutic use of animals.
There are currently 300 therapeutic proteins in the biopharmaceutical industry's development pipeline, while those already on the market will soon be out of patent and ripe for exploitation as generics.
The discovery, published today in the journal Nature Communications, opens the door to the development of new therapeutic targets to fight these types of cancer.
The next objective of the researchers is to decode the action mechanism of TREX2 in the development and maintenance of psoriasis, so as to design new therapeutic strategies for the treatment of this disease.
As a result, the emphasis in early development is on understanding the molecular underpinnings of disease and developing markers for therapeutic effects.
«No one had cracked how to make RNA stable enough to be a therapeutic,» says Mene Pangalos, who heads the Innovative Medicines and Early Development Biotech Unit at AstraZeneca in Cambridge, U.K.
The work published in Cancer Cell complements previous research efforts from the CNIO Melanoma Group, which could lead to the development of novel drugs that selectively target the mechanism of cell autodigestion as a potential therapeutic strategy.
«We are excited by the work of Dr. Pourdehnad and colleagues and believe these results are an important advance in understanding the role of myc pathway dysregulation in multiple myeloma, and ultimately allow for the development of therapeutic strategies to address it,» said Jeffrey Wolf, MD, a UCSF blood disorder specialist and director of the Stephen and Nancy Grand Multiple Myeloma Translational Initiative at UCSF, a sponsor of the research.
The work demonstrates that BRAF - mutated melanoma requires autophagy for tumor development and blocking autophagy could have therapeutic value, particularly in combination with BRAF inhibition.
«While inclusion of such MIPs in a cosmetic product will require much formulation development, it is clear to see the potential of imprinting technology in a range of topical applications, both cosmetic and therapeutic.»
Dr. Paul R. Sanberg, Distinguished University Professor, a co-author of the paper, concluded that «these novel data showing BSCB damage in subacute and chronic ischemic stroke may lead to development of new therapeutic approaches for patients with ischemic cerebral infarction.»
A 2010 survey by the market analysis firm BCC Research identified 113 therapeutic vaccines in development, many already in human trials.
«There are no new therapeutic drugs in development,» says Manjula Lusti - Narasimhan of the WHO's Department of Reproductive Health and Research.
«A significant amount of work remains in the development of teixobactin as a therapeutic antibiotic for human use — we are probably around six to ten years off a drug that doctors can prescribe to patients — but this is a real step in the right direction and now opens the door for improving our in vivo analogues.»
«Two classes of GGAA - microsatellites in a Ewing sarcoma context: Characterization of GGAA - microsatellites provides insight in the role of noncoding DNA in cancer susceptibility and therapeutic development.»
Dr Ishwar Singh, a specialist in novel drug design and development from the University of Lincoln's School of Pharmacy, said: «Translating our success with these simplified synthetic versions from test tubes to real cases is a quantum jump in the development of new antibiotics, and brings us closer to realising the therapeutic potential of simplified teixobactins.
In addition to Abbott and his medical school colleagues, the research team included representatives of Oncodesign, a therapeutic molecule biotechnology company in Dijon, France; Janssen Research & Development, a New Jersey - based pharmaceutical company; andAsclepia Outsourcing Solutions, a Belgium - based medicinal chemistry companIn addition to Abbott and his medical school colleagues, the research team included representatives of Oncodesign, a therapeutic molecule biotechnology company in Dijon, France; Janssen Research & Development, a New Jersey - based pharmaceutical company; andAsclepia Outsourcing Solutions, a Belgium - based medicinal chemistry companin Dijon, France; Janssen Research & Development, a New Jersey - based pharmaceutical company; andAsclepia Outsourcing Solutions, a Belgium - based medicinal chemistry company.
Baucher switched to a new master's program in pharmaceutical development and therapeutic innovation at the University of Poitiers, finishing in 2005.
The role of Apelin and Elabela in establishing the circulatory system makes them potential targets in future development of therapeutic applications for illnesses ranging from the various cancers, and cardiovascular diseases, to even metabolic diseases such as diabetes.
His research focuses predominantly on oncology molecular diagnostics, particularly the source and utility of miRNA biomarkers in blood, and the development of innovative molecular diagnostics for the identification of mutations that can guide therapeutic decision - making.
Novo Nordisk is a global healthcare company with almost 90 years of pioneering innovation in the discovery, design, development and delivery of therapeutic proteins.
The Myelin Repair Foundation, which funded this work as part of a multi-institutional effort to accelerate research and development of treatments for MS, has entered into a cooperative agreement with the National Institutes of Health to assess guanabenz as a therapeutic candidate in MS clinical studies.
Compelling infographics round out this robust examination, illustrating data sets on the costs of developing drugs, the major shifts in global demographics and patient needs, the explosions of data that must be mined for future therapeutic development, and the health spending of a wide variety of nations.
For decades, the Tourette Association of America has led the way in research and therapeutic development for Tourette Syndrome and other Tic Disorders, and has provided more than $ 20 million in grants to fund research and develop medical programs that meet the needs of those affected by Tourette.
We are concerned that a public outcry about such an ethical breach could hinder a promising area of therapeutic development,» write Lanphier and his colleagues, who include Fyodor Urnov, a pioneer in gene - editing techniques and scientist at Sangamo BioSciences in Richmond, California.