Not exact matches
That suggests an opportunity to expand the «
therapeutic window,» or the
range of
doses at which a drug may be administered safely, she said.
Instead of just weight based
dosing with empiric
dose escalation for symptoms, we propose monitoring the serum drug concentrations and adjusting the
dose to achieve a drug concentration within the
therapeutic range.»
The phenobarbital
dose must maintain the phenobarbital blood level within a safe
therapeutic range and be adjusted accordingly.
Once the
therapeutic dose for your pet is determined, phenobarbital blood levels and liver function tests will need to be monitored at least every six months to ensure that your pet's blood levels stay within the
therapeutic range (i.e. that they do not get dangerously high or low), and that the no damage to the liver is occurring.
Digoxin has a very narrow
therapeutic range (the toxic and
therapeutic doses are similar) and it does not increase contractility very much.
Trials comparing the same antidepressant at different
therapeutic doses will be merged in the same node in the network analysis so long as they are within the
dose range licensed by drug regulatory agencies.