In studies to understand the molecular basis for
therapeutic drug action, he showed how tiotropium bromide (Spiriva), an inhaled drug for chronic obstructive pulmonary disease and for uncontrolled asthma, recognizes and blocks the muscarinic 3 (M3) receptor.
Not exact matches
Determining the detailed molecular mechanism that mediates the
therapeutic actions of cannabidiol may suggest development strategies for new
drugs aimed at GPR55, according to the researchers.
The study, called «Molecular Determinants of
Drug - Specific Sensitivity for Epidermal Growth Factor Receptor (EGFR) Exon 19 and 20 Mutants in Non-Small Cell Lung Cancer,» and published online in the journal Oncotarget, demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of
action and consequently optimize the selection of
therapeutic agents to treat patients.
The system can be used by researchers as a model to elucidate how viral infections contribute to exacerbations, gain insight into mechanism of
action of
drugs, and could potentially help identify new
therapeutic targets.
With benzodiazepines / Z -
drugs, specifically, when the receptors in the brain become adapted or accustomed to the
action of the original dose of BZ, more of the
drug is needed in order for the desired
therapeutic effect (or the original effect at the original dose) to be achieved.
The approach by body system in this course serves to provide the necessary background information and to refresh the student's memory of previously learned material through which the
therapeutic action of the
drugs can be clearly understood.