Sentences with phrase «therapeutic drug development»

SAN DIEGO, March 28, 2017 (GLOBE NEWSWIRE)-- Invivoscribe ® Technologies Inc., a global company with decades of experience providing internationally standardized clonality and biomarker testing solutions for the fields of oncology, personalized molecular diagnostics ®, and personalized molecular medicine ®, reports that its next - generation sequencing (NGS) LymphoTrack ® Assay kits are being used by its LabPMM ® clinical laboratories, pharmaceutical partners, and cancer centers to identify and monitor chimeric antigen receptor T - cells (CAR - T) and engineered T - cell receptors in peripheral blood of subjects in support of immuno - therapeutic drug development and treatment regimen development for both hematologic and solid tumors.

Interactive sessions will present basic and clinic research focusing on advances in virology, therapeutic drug development and practical -LRB-...)

Not exact matches

Jennifer has more than 20 years of regulatory experience, integrating regulatory strategy into drug development and precision medicine across multiple therapeutic areas.

«It essentially gives us a periodic table,» Ron DePinho, President of MD Anderson Cancer Center says, which has provided us with both diagnostic and therapeutic value as well as helped us design clinical trials to accelerate the development of new cancer drugs,».

It also can keep out therapeutic drugs and, when defective, biomolecules that are needed for healthy brain development.

In addition, risks associated with the usability, therapeutic efficacy and market share of medicinal substances are usually realized only in the final stages of drug development.

Of approximately 300 staff at the Center for Therapeutic Research, only nine postdocs and students are conducting basic research; the rest work in drug discovery and development.

Richard Hargreaves, executive director of imaging at Merck Research Laboratories, says, «Nuclear imaging using radiotracers gives the opportunity to put your arms around proof - of - concept very early in a drug discovery and development program by focusing the selection of doses to study on those proven to deliver enough drug to the target therapeutic sites.»

Determining the detailed molecular mechanism that mediates the therapeutic actions of cannabidiol may suggest development strategies for new drugs aimed at GPR55, according to the researchers.

«Using approved therapies for one condition to treat another, or drug repurposing, offers new avenues to speed Parkinson's therapeutic development,» said Dr Brian Fiske, senior vice president of research programs at MJFF.

Their control requires the continuous development of new and potent antiviral drugs / therapeutic options.

The work published in Cancer Cell complements previous research efforts from the CNIO Melanoma Group, which could lead to the development of novel drugs that selectively target the mechanism of cell autodigestion as a potential therapeutic strategy.

«Potent parasite - killing mechanism of anti-malarial drug uncovered: New understanding of how artemisinin works could facilitate development of new drugs and therapeutic strategies against malaria.»

«There are no new therapeutic drugs in development,» says Manjula Lusti - Narasimhan of the WHO's Department of Reproductive Health and Research.

«A significant amount of work remains in the development of teixobactin as a therapeutic antibiotic for human use — we are probably around six to ten years off a drug that doctors can prescribe to patients — but this is a real step in the right direction and now opens the door for improving our in vivo analogues.»

Dr Ishwar Singh, a specialist in novel drug design and development from the University of Lincoln's School of Pharmacy, said: «Translating our success with these simplified synthetic versions from test tubes to real cases is a quantum jump in the development of new antibiotics, and brings us closer to realising the therapeutic potential of simplified teixobactins.

«These results are particularly exciting because they suggest that drugs directed at fusion - circular RNAs could be a powerful strategy to pursue for future therapeutic development in cancer,» said Pandolfi.

This microRNA — miR -124-3p — is thus a potential therapeutic target for novel drug development, and it can serve as a putative biomarker for MDD pathogenesis.

Compelling infographics round out this robust examination, illustrating data sets on the costs of developing drugs, the major shifts in global demographics and patient needs, the explosions of data that must be mined for future therapeutic development, and the health spending of a wide variety of nations.

Like other big pharma companies, Pfizer is partnering with academic institutions to share the risk of drug development and take advantage of academic scientists» broad base of knowledge, says Boston - based Anthony Coyle, vice president of the Centers for Therapeutic Innovation (CTI) at Pfizer.

The committee was split evenly on whether the development of a vaccine to prevent hepatitis C would also meet the standard, but agreed that under the criteria neither development of a therapeutic vaccine nor of drugs to treat hepatitis C could justify the use of chimpanzees.

An impermeable shield of endothelial cells that protects our brains from toxins and other threats that may lurk in circulating blood, the barrier can also exclude therapeutic drugs and, at times, essential biomolecules required for healthy brain development.

Professor Andrew Lotery, who led the Southampton contribution, hopes the findings may help improve the understanding of the biological processes that lead to AMD and identify new therapeutic targets for potential drug development.

ISIS PHARMACEUTICALS» FORWARD - LOOKING STATEMENT This press release includes forward - looking statements regarding the discovery, development and potential of drugs for severe and rare diseases, and the development, activity, therapeutic potential and safety of ISIS - SMNRx.

These forward - looking statements are based on management's current assumptions and expectations and involve risks, uncertainties and other important factors, specifically including those relating to Lexicon's ability to successfully conduct preclinical development of its drug candidates and advance such candidates into clinical development, achieve its operational objectives, obtain patent protection for its discoveries and establish strategic alliances, as well as those relating to manufacturing, the regulatory process, intellectual property rights, and the therapeutic or commercial value of its drug candidates, that may cause Lexicon's actual results to be materially different from any future results expressed or implied by such forward - looking statements.

Therapeutic Pipeline Program is open to industry and academic investigators working at either pre-clinical or clinical stages of drug and therapeutic dTherapeutic Pipeline Program is open to industry and academic investigators working at either pre-clinical or clinical stages of drug and therapeutic dtherapeutic development.

The symposium brings together leaders in biology, medicine, and industry to present on the latest advances in technology development, mechanistic understanding, and therapeutic application of stem cells for both drug development and cell - based therapy.

Small is also better in the drug development process, during which researchers may screen hundreds of thousands of compounds to find a «hit» for a particular therapeutic need.

Conference mainly focuses on: • Translational medicine approaches in drug discovery & development • Cardio - Vascular Translational Medicine • Translational Haematology • Translational therapeutics / Novel therapeutic technologies • Clinical and Translational Oncology • Translational Neuroscience...

We believe that leveraging human intuition through creation of a scientific game for drug discovery can not only provide a new avenue to discover therapeutic drugs for protein targets, but can also contribute to the development of new sophisticated algorithms to use in computer aided drug design.

«Our findings suggest that apoE4 inhibits the development of newborn neurons by impairing specific signaling pathways and that boosting these pathways with drugs may be of therapeutic benefit,» said Dr. Huang.

We are now extending the previous metabolomics genetics studies to inform drug development in a project funded by the Center for Therapeutic Target Validation.

For the later stages of my career, I have been thinking about therapeutic targets and the development of new drugs.

In this protein, the binding domain of botulinum toxin is replaced to broaden the toxin's therapeutic potential and allow drug development to be targeted towards a specific disease.

«The tenfold increase of circulation time in the body is important in drug development and paves the way towards clinical trials of RNA nanoparticles as therapeutic drugs.»

The ability to encapsulate small - molecule therapeutic compounds into vaults is critical to their development for drug delivery.

Charting the network of discoveries that led to the development of important therapeutic drugs, the investigators revealed that, up to now, the path to a cure has required thousands of scientists and many decades.

In the U.S., orphan drug designation is granted by the FDA's Office of Orphan Products Development to promote the development of products that may offer therapeutic benefits for diseases with a prevalence of fewer than 200,000 individualDevelopment to promote the development of products that may offer therapeutic benefits for diseases with a prevalence of fewer than 200,000 individualdevelopment of products that may offer therapeutic benefits for diseases with a prevalence of fewer than 200,000 individuals per year.

Translational medicine is the integrated application of innovative pharmacology tools, biomarkers, clinical methods, clinical technologies and study designs to improve disease understanding, confidence in human drug targets and increase confidence in drug candidates, understand the therapeutic index in humans, enhance cost - effective decision making in exploratory development and increase phase II success.

A significant focus of the Structural Biology Group is the exploitation of structural information to engineer macromolecules for therapeutic applications, including gene correction, vaccine development, and drug discovery.

Detailed molecular profiling investigations alongside antitumor testing and tolerability studies in animals suggest caution when considering the clinical development of inhibitors of CDK8 and CDK19, since a clear therapeutic window could not be demonstrated with two structurally distinct, potent and selective prototype drugs.

Investigational New Drug Application (IND)-- a key step in development of a new drug or medical treatment in which the US Food and Drug Administration (FDA) is notified that a novel therapeutic will be used experimentDrug Application (IND)-- a key step in development of a new drug or medical treatment in which the US Food and Drug Administration (FDA) is notified that a novel therapeutic will be used experimentdrug or medical treatment in which the US Food and Drug Administration (FDA) is notified that a novel therapeutic will be used experimentDrug Administration (FDA) is notified that a novel therapeutic will be used experimentally

Dr. Rokosz was employed with Schering - Plough, Merck and Pharmacopeia where she honed her drug development skills in many therapeutic areas including, but not limited to, Metabolic Diseases, Autoimmune disorders and Cancer.

It is focused on the development of preventive and therapeutic vaccine products and cancer drugs for patients with unmet medical needs.

Summary: Experienced cell / molecular biologist with background in bioanalytics, cell - based & ligand bind - ing assay development / validation, early discovery of therapeutic biologics and anticancer drugs.

Summary: * Several years of clinical experience in the industry with excellent knowledge of drug development in different therapeutic areas including oncology, immunology, vaccines, metabolism and biosimilars.

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She has worked extensively with childhood trauma and neglect (emotional, physical and sexual — both victims and offenders of all ages, including the development of a therapeutic foster care program for sexualized children), domestic violence (both victims and batterers), addictions (inpatient and outpatient evaluation and treatment / drugs, alcohol, and sexual), somatic disorders and war trauma.