Sentences with phrase «therapeutic drug toxicity»

Not exact matches

«By administering chemotherapy within this «therapeutic window,» oncologists could apply a lower dose of chemotherapy drugs to patients, with the potential for an improved treatment outcome — all while minimizing drug toxicity to healthy organs,» He said.

«For prevention, where a drug is given before the symptoms of Alzheimer's disease appear, and likely over longer periods of time, bexarotene is not likely a viable therapeutic because of this known toxicity unless dosing is carefully controlled and patients are closely monitored.»

«The circadian clock regulates certain signaling pathways that are key for minimizing drug toxicity in normal tissues and increasing anticancer therapeutic drug efficacy,» said Shobhan Gaddameedhi, PhD, College of Pharmacy, Washington State University, Pullman, Washington, and senior author of this study.

It meets a particularly pressing need in oncology, where, as Ratain and O'Donnell wrote in Molecular Oncology this past January, the window between therapeutic and toxic for drugs «is often narrow, the need for favorable drug response is often acute and the consequences of drug toxicity can be life - threatening.»

We currently evaluate the therapeutic benefits as well as the toxicity of drug candidates in spheroids by means of conventional fluorescence microscopy as well as LSFM and many different biochemical and molecular biology - based assays (Ansari et al. 2013; Wenzel et al. 2014; Pampaloni & Stelzer 2010).

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