Sentences with phrase «therapeutic efficacy»

Then scientists tried to see if these parameters could predict therapeutic efficacy.

Within every phase of treatment, specialized advice is displayed to guide the technician through the intricacies of treatment technique that provide maximum therapeutic efficacy.

Within every phase of treatment, specialized advice is displayed to guide the technician through the intricacies of treatment techniques that provide maximum therapeutic efficacy.

This novel and informative work may provide an immunologic explanation for the observed therapeutic efficacy of autologous HSPC transplantation in T1D and pave the way for new therapeutic interventions in the future.

«We report much higher therapeutic efficacy in preclinical brain tumor models using the combination of both therapies, leading to an increase in median survival,» Lowenstein says.

The estimation of EGFR mutation status is essential for the identification of non-small cell lung carcinoma (NSCLC) patients who may benefit from treatment with EGFR tyrosine kinase inhibitors (TKIs), and hence for improving therapeutic efficacy.

Arming Tumor - Reactive T Cells with Costimulator B7 - 1 Enhances Therapeutic Efficacy of the T Cells

Research conducted over the last two decades has established therapeutic efficacy of cryotherapy in a wide range of clinical areas.

«If nanoparticles are carrying a drug to deliver, different uptake could mean different therapeutic efficacy and other important differences, such as safety, in clinical data.»

Basic science is also critical: Unraveling the complex interplay of cells in the tumor microenvironment, understanding how tumor mutational load influences therapeutic efficacy, and dissecting how our resident microbes shape the development and treatment of cancer will also provide important insights that will forge the way toward improving existing therapies and developing new ones.

The next hurdle will be proof of therapeutic efficacy where we actually take an IgA antibody targeted to a specific protein or growth factor and see if it can inhibit cyst growth.»

Moreover, globally enhanced tumor vessel perfusion could be detected by Doppler ultrasonography before changes in tumor size, which predicted final therapeutic efficacy with more than 90 % sensitivity and specificity.

Theoretically, this precise molecular characterization of human disease will allow us to understand the basis for disease susceptibility and environmental influence; to offer an explanation for the different phenotypic manifestations of the same disease; to define disease prognosis with greater accuracy; and to refine and, ideally, individualize disease treatment for optimal therapeutic efficacy.

Taken together, the robust therapeutic efficacy observed in primates and the potential for broad - spectrum antiviral activity suggest that further development of GS - 5734 for the treatment of Ebola virus and other viral infections is warranted, Bavari said.

Several gene therapy clinical trials using gene - modified hematopoietic stem cells have shown therapeutic efficacy in multiple disease areas.

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

Excitingly, the in vitro expansion of MuSC cultures in the presence of PFI - 2 increased the yield and maintained the self - renewal capacity of MuSCs, and following transplantation into injured tibialis anterior muscles of muscular dystrophy model mice, boosted MuSC engraftment and overall therapeutic efficacy.

«We need to consider the reliability and the long - term therapeutic efficacy of this device in large animals before we can push this device to clinics.»

Barouch DH, Whitney JB, Moldt B, Klein F, Olivera TY, Shekhar K, Gupta S, Liu J, Nkolola JP, Seaman MS, Smith KM, Borducchi EN, Cabral C, Smith JY, Blackmore S, Bajimaya S, Beck M, Lewis MG, Ferguson M, Chakraborty AK, Poignard P, Nussenzweig MC, Burton DR Therapeutic Efficacy of Potent Neutralizing HIV -1-Specific Monoclonal Antibodies in SHIV - Infected Rhesus Monkeys.

As a result, you can begin targeted treatment immediately, for greater therapeutic efficacy and reduced risk of complications & side effects associated with incorrect treatment or unwarranted antimicrobial administration.

«When the decision is reached to use antimicrobials for treatment, control, or prevention of disease, veterinarians should strive to optimize therapeutic efficacy and minimize resistance to antimicrobials to protect public and animal health and well - being.»

We hypothesized that plasma concentrations associated with therapeutic efficacy would be maintained for 72 hours after a single subcutaneous administration of ERB.

Jivko Stoyanov (Swiss Paraplegic Research, Nottwil, Switzerland) has suggested that in vitro cell motility could be used as an easy and quick method of evaluating an MSC population for its potential therapeutic efficacy, and his laboratory now report on this hypothesis in Stem Cells Translational Medicine [2].

Careful documentation of blood glucose and ketone levels will be essential for predicting therapeutic efficacy.

M.Y.: The company is focused in large part on coming up with specific combinations of growth factor receptor inhibitors that have therapeutic efficacy in cancer.

In vivo prophylactic and therapeutic efficacy of human mAbs against pandemic H1N1 influenza virus.

«This gives us an underlying candidate biomarker panel that provides information on the subsequent clinical outcome or therapeutic efficacy, which can be validated to yield a final panel, then translated into say, an ELISA - based kit or some other immunodiagnostic format in the clinical setting,» says Dorfman.

In addition, risks associated with the usability, therapeutic efficacy and market share of medicinal substances are usually realized only in the final stages of drug development.

«Randomized trials have confirmed the value of radiation dose escalation for prostate tumors, and the potential benefits of larger radiation doses in fewer fractions, are expected to increase the therapeutic efficacy for men with prostate cancer,» said Anders Widmark, MD, a professor of radiation sciences at Umeå University in Umeå, Sweden and lead author of the study.

It is known that mutations in the PI3K protein signaling pathway occur in 16 % of patients with PanNETs; in the present study, the researchers assessed the frequency of PI3K pathway activation in 40 human tumor samples and in a mice model of PanNETs, and they investigated the therapeutic efficacy of inhibiting this pathway in mice using PI3K generic and isoform - specific inhibitors.

The process of drug discovery involves the identification of candidates, synthesis, characterization, screening, and assays for therapeutic efficacy.

These drugs subsequently have low bioavailability (i.e., they are difficult for the body to take up), which limit their therapeutic efficacy and hence seldom leads to new pharmaceuticals.

«Our work and that of our colleagues on stress and CRF have been mechanistically implicated in Alzheimer's disease, but agents that impact CRF signaling have not been carefully tested for therapeutic efficacy or long - term safety in animal models,» said the study's principal investigator and corresponding author Robert Rissman, PhD, assistant professor in the Department of Neurosciences and Biomarker Core Director for the Alzheimer's Disease Cooperative Study (ADCS).

Indeed, this study shows that the therapeutic efficacy of a new drug that is currently in clinical trial depends on Sestrin1.

They also are working to improve understanding of the therapeutic efficacy of simultaneously targeting multiple tumor - specific molecules on the surface of metastatic cells within the brain and anticipate that their findings will make a major contribution towards developing novel targeted therapies for metastatic tumors in the brain.

They found that PD - L1 immune checkpoint blockade significantly improved the therapeutic efficacy of stem cell based oncolytic virotherapy in melanoma brain metastasis.

To determine the therapeutic efficacy of the mAbs, mice were challenged with 3xLD50 of the mouse - adapted pandemic H1N1 virus.

The trial, sponsored by Généthon, will include 17 patients in four centres in Europe, and will assess safety and therapeutic efficacy of the gene therapy product developed by Généthon.

Phinney DG Biochemical heterogeneity of mesenchymal stem cell populations: clues to their therapeutic efficacy.

On the other hand, we design drug conjugates to improve their pharmacokinetic profile and therapeutic efficacy.

Research Paper Plectin - targeted liposomes enhance the therapeutic efficacy of a PARP inhibitor in the treatment of ovarian cancer Siva Sai Krishna Dasa, Galina Diakova, Ryo Suzuki, Anne M. Mills, Michael F. Gutknecht, Alexander L. Klibanov, Jill K. Slack - Davis, Kimberly A. Kelly Theranostics 2018; 8 (10): 2782 - 2798.

The Tg5453 mouse model was successfully used in establishing the therapeutic efficacy of Remicade ®, the first anti-TNF therapeutic to be successfully applied in the clinic, and is recommended by the FDA for screening potential anti-rheumatoid candidate drugs.