Sentences with phrase «therapeutic index»

«If a person is stable on narrow therapeutic index drug, it makes sense to think two times about changing to a generic or to a new brand - name drug,» Kesselheim says.

Although both forms are highly active, ADCs with alkylating IGNs demonstrated a better safety profile, and high therapeutic indices in vivo.23, 24 Here we describe the development and preclinical characterization of a novel CD123 - targeting ADC, IMGN632, consisting of a humanized anti-CD123 antibody conjugated to an alkylating IGN payload via a protease cleavable linker.

It's convenient and has a wide therapeutic index which makes this drench an exceptionally valuable product for parasite control in sheep.

The minority of patients for whom a switch might be problematic are those on narrow - margin therapeutic index drugs, such as anticoagulants and antihypertension meds for which there is a fine line between a dosage that is beneficial and one that is toxic.

That's just one of the reasons FloraGLO is trusted most by doctors — based on the results of the National Disease and Therapeutic Index syndicated report among physicians who recommend a dietary supplement with lutein for eye health between September 2009 and September 2010 — and is the brand being used in the National Eye Institute's AREDS 2 trial.

It is a very poor therapeutic index,» Russo says.

This research was effectuated to create a theranostic bioconjugate with an optimal effective therapeutic index, achieved by biomarker - specific targeting.

Thyroid hormones are known to have a very narrow therapeutic index — they are «Goldilocks» medications in that have to be dosed just right to ensure effectiveness and prevent adverse drug events.

In the hands of trained professionals — and with laboratory - grade equipment — fentanyl actually has a pretty wide therapeutic index, or range within which the drug is both effective and safe.

However; more clinical trials are needed to clarify indications and therapeutic index.

A key concern with the stimulation of STING pathway is the risk of adverse events due to the systemic production of interferon, a biologic with a narrow therapeutic index.

Translational medicine is the integrated application of innovative pharmacology tools, biomarkers, clinical methods, clinical technologies and study designs to improve disease understanding, confidence in human drug targets and increase confidence in drug candidates, understand the therapeutic index in humans, enhance cost - effective decision making in exploratory development and increase phase II success.

A: Selenium appears to be a supplement with a narrow therapeutic index.

Importantly, iodine is a narrow therapeutic index or «Goldilocks» nutrient.

Selenium appears to be a supplement with a narrow therapeutic index.

Thyroid hormones have a very narrow therapeutic index, so that small difference may be making you feel hyperthyroid.

Thyroid hormones are known to have a very narrow therapeutic index, they are «Goldilocks» medications, in that have to be dosed just right to ensure effectiveness and prevent adverse drug events.

Thyroid medications are referred to as «goldilocks» hormones, which mean that they have a narrow therapeutic index.

And the therapeutic index, which is the difference between the dose that is toxic to the host and the dose that eliminates heartworm in the host is a factor of three.

The changes in these scores from baseline were combined to produce a therapeutic index of change for each outcome.