Sentences with phrase «therapeutic models in»

For example, when treating someone who had run afoul of the law, they would encourage the individual to see him - or herself as a person who has made mistakes rather than a felon.White and Epston grounded this new therapeutic model in three main ideas.

At ConnectEd, we include the family within the therapeutic model in order to support parents in learning to observe and interpret their child's behavior, to enrich their child's everyday routines and activities, and to assist families in anticipating next steps in development.

Not exact matches

Self - help groups (many of which are modeled on Alcoholics Anonymous) represent one of the most hopeful developments in the whole field of contemporary therapeutic groups.

Also, attempts over the past generation to dispense with the pastoral model in favor of a therapeutic one — in which the minister is one professional alongside others — have been unsatisfying.

Attempts over the past generation to dispense with the pastoral model in favor of a therapeutic one — in which the minister is one professional alongside others — have been unsatisfying.

Dihydrocaffeic acid and malvidin - 3» - O - glucoside were used as a «prophylactic and therapeutic» treatment in an animal model.

Union officials and CSEA members who work in the state's youth detention facilities had been working with the agency to move from a correction model to a so - called «sanctuary model» which centers on reducing or eliminating restraints and creating a more therapeutic environment focused on staff building relationships with residents.

Further studies in animal models and patients (with altered TRPM7 channel function) have been initiated, in order to evaluate the efficacy and safety of magnesium as a therapeutic for this disease.

«Moving to non-invasive and repeatable methods of nerve fiber measurements such as in vivo corneal confocal microscopy would enhance study of peripheral neuropathy by enabling early detection of damage, progression of nerve fiber deterioration, and enable assessment of therapeutic strategies in the SIV / macaque model,» explains Dr. Mankowski.

We demonstrated that DENV serotype 2 (DENV2)-- specific human monoclonal antibody (HMAb) 2D22 is therapeutic in a mouse model of antibody - enhanced severe dengue disease.

For now, Rashid's group has a list of candidate therapeutic drugs that they'll test in their new liver disease models, something that may still prove useful to patients.

«We know that 70 - 75 percent of glioblastoma patients undergo surgery for tumor debulking, and we have previously shown that MSCs encapsulated in biocompatible gels can be used as therapeutic agents in a mouse model that mimics this debulking,» he continued.

By hitting breast cancer cells with a targeted therapeutic immediately after chemotherapy, researchers from Brigham and Women's Hospital (BWH) were able to target cancer cells during a transitional stage when they were most vulnerable, killing cells and shrinking tumors in the lab and in pre-clinical models.

From accelerating the identification and validation of novel therapeutic targets, to creating better animal models of human diseases in a shorter time frame, to reducing the number of failed products, Crispr looks set to shave millions off R&D costs and boost drug discovery, she says.

Because the researchers found that CTLA4Ig was effective in suppressing hepatitis in this study, they suggest that CTLA4Ig should be among the therapeutic options investigated further as a potential therapy for patients with severe acute hepatitis B. To this end, this animal model is useful for virological and immunological analysis of HBV infection.

Treatment in a mouse model of metastatic breast cancer with two of the down - regulated miRNAs (miR - 141 and miR - 219) suppressed bone metastases, suggesting that these miRNAs may have therapeutic utility.

Building on these findings, the researchers demonstrated the utility of their T cell expansion platform in a therapeutic model.

Shah next plans to rationally combine the toxin - secreting stem cells with a number of different therapeutic stem cells developed by his team to further enhance their positive results in mouse models of glioblastoma, the most common brain tumor in human adults.

«Our work and that of our colleagues on stress and CRF have been mechanistically implicated in Alzheimer's disease, but agents that impact CRF signaling have not been carefully tested for therapeutic efficacy or long - term safety in animal models,» said the study's principal investigator and corresponding author Robert Rissman, PhD, assistant professor in the Department of Neurosciences and Biomarker Core Director for the Alzheimer's Disease Cooperative Study (ADCS).

Recently, Dr. Cohen's laboratory obtained an ethical approval to test the therapeutic efficiency of NT219 as a treatment in Alzheimer's - model mice, hoping to develop a future treatment for hitherto incurable neurodegenerative disorders.

The study, called «Molecular Determinants of Drug - Specific Sensitivity for Epidermal Growth Factor Receptor (EGFR) Exon 19 and 20 Mutants in Non-Small Cell Lung Cancer,» and published online in the journal Oncotarget, demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patients.

The paper, by S.S. Karuppagounder at Burke Medical Research Institute in White Plains, N.Y., and colleagues was titled, «Therapeutic targeting of oxygen - sensing prolyl hydroxylases abrogates ATF4 - dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.»

But this remarkable therapeutic benefit isn't limited to MS. Previous research in animal models that mimic other diseases suggest that certain forms of amyloids can ease damage from strokes, traumatic brain injuries and even heart attacks.

The computational protocol, which was validated by assembling physical peptides in the chemistry lab and comparing them to the computer models, may one day enable drug developers to craft novel, therapeutic peptides that precisely target specific disease - causing molecules within the body.

To study the suitability of guanabenz as a therapeutic after MS symptoms have already appeared and peaked, the researchers used a mouse model in which symptoms relapse and remit — cycling from high severity to low severity to high again over time.

«Although this is basic scientific research using animal models, these studies are shedding light on the molecular mechanisms that control male fertility, and are helping us to better understand the causes of many cases of infertility and enabling new horizons to be opened up in the development of therapeutic targets and strategies to combat it,» explained Dr Subirán.

The CUMC team is currently using the new mouse model to study signaling pathways in the brain that drive anorexic behavior, with the ultimate goal of identifying therapeutic targets.

«We report much higher therapeutic efficacy in preclinical brain tumor models using the combination of both therapies, leading to an increase in median survival,» Lowenstein says.

Dr. Zhu said he believes the study provides the scientific community with an important animal model to further investigate ARID1B's role in human brain disorders and will be a useful tool for therapeutic testing of potential treatments for autism, intellectual disability, and Coffin - Siris syndrome.

«The induced pluripotent stem cells we used in this study proved to be extremely useful in disease modelling, and they could offer an excellent platform for drug discovery and testing new therapeutic targets for Alzheimer's disease in the future,» says Early Stage Researcher Minna Oksanen, the lead author of the study.

«Novel imaging model helps reveal new therapeutic target for pancreatic cancer: Antisense treatment in preclinical models shows effectiveness against deadly tumors.»

In a new study, published online June 6 in Nature, researchers at University of California San Diego School of Medicine and Moores Cancer Center, together with colleagues at Keio University, the University of Nebraska and Ionis Pharmaceuticals describe an innovative new model that not only allowed them to track drug resistance in vivo, but also revealed a new therapeutic target, which early testing suggests could provide a strategy to arrest pancreatic cancer growtIn a new study, published online June 6 in Nature, researchers at University of California San Diego School of Medicine and Moores Cancer Center, together with colleagues at Keio University, the University of Nebraska and Ionis Pharmaceuticals describe an innovative new model that not only allowed them to track drug resistance in vivo, but also revealed a new therapeutic target, which early testing suggests could provide a strategy to arrest pancreatic cancer growtin Nature, researchers at University of California San Diego School of Medicine and Moores Cancer Center, together with colleagues at Keio University, the University of Nebraska and Ionis Pharmaceuticals describe an innovative new model that not only allowed them to track drug resistance in vivo, but also revealed a new therapeutic target, which early testing suggests could provide a strategy to arrest pancreatic cancer growtin vivo, but also revealed a new therapeutic target, which early testing suggests could provide a strategy to arrest pancreatic cancer growth.

Knowing that Notch governs vessel permeability makes it a candidate for new drugs to treat cardiovascular diseases as well, and the team is also investigating the TMD as a potential therapeutic agent itself, as cell models that were exposed to leak - inducing inflammation displayed a dramatic reduction in leakage when they were engineered to express the TMD.

Metabolites derived from the microbiome block protein misfolding in test tubes and prevent neurodegeneration in a fly model of a disease related to Parkinson's, hinting that gut - derived metabolites may hold therapeutic promise (Lap Ho, abstract 573.23, see attached summary).

The study of these new mouse models means an advance in the knowledge of disease's development mechanisms and an opportunity to implement new therapeutic strategies for patients.

Interestingly, the team showed that combining anti-angiogenic and immune - stimulating therapies in the treatment of tumors in mouse models resulted in better therapeutic outcomes by providing white blood cell gates through which they can infiltrate cancers.

New research shows that a bioactive compound called resolvin D - 1, injected as a therapeutic dose, is able to limit this collateral damage in the kidneys, as tested in an animal model.

«The multiple in vitro and in vivo models that we used have varying genetic backgrounds and yet they all still show susceptibility to this novel and exciting therapeutic combination.»

When STAT3 was knocked out in a mouse model, researchers observed increased T - cell immune responses, suggesting a valuable therapeutic target.

«Our results in experimental models of cancer suggest a new therapeutic strategy based on inhibiting the microRNA machinery — or the Let - 7 microRNAs — specifically in the TAMs, which may unleash the power of mainstream immunotherapies, such as immune checkpoint inhibitors.»

In mouse models of cancer, targeted therapeutic inhibition of translation disrupts this survival response, dramatically slowing tumor growth and potentially rendering drug - resistant tumors vulnerable to other therapies.

Sensitive and analogous behavioral assays in animal models and humans are needed to improve the translational predictability of therapeutic strategies.

In the case of influenza, mAbs have been shown to provide prophylactic or therapeutic protection in mice and other animal models (Reuman et al., 1983; Sweet et al., 1987; Palladino et al., 1995; Renegar et al., 2004In the case of influenza, mAbs have been shown to provide prophylactic or therapeutic protection in mice and other animal models (Reuman et al., 1983; Sweet et al., 1987; Palladino et al., 1995; Renegar et al., 2004in mice and other animal models (Reuman et al., 1983; Sweet et al., 1987; Palladino et al., 1995; Renegar et al., 2004).

Several tests in cultured cells indicated that ganciclovir would cause the death of HSV - TK - expressing stem cells, and testing in the mouse model confirmed that administration of the drug after successful treatment of brain metastases successfully eliminated therapeutic stem cells that also expressed HSV - TK.

Tagged therapeutic stem cells (green) are targeting breast cancer metastases (red) in the brain of a mouse model.

Once this work is completed, a second stage is committed, in which researchers of I - Stem, in collaboration with specialists in animal models of diseases targeted by the therapeutic explore the effects of experimental transplantation of cells obtained laboratory.

After their initial in vitro testing, therapeutic proofs of concept must be tested in a living model that recapitulates as closely as possible both the phenotype and biological defects associated to the human disease.

The Microbiology Services Division at Porton Down, part of the National Infection Service directorate, has extensive high - containment laboratory facilities and rare capabilities to handle infectious organisms under the highest levels of containment, and the ability to work with in vivo models to evaluate new therapeutic interventions against these organisms.

A major asset of the OMC platform is the tight integration of preclinical scientists with physicians, who work side by side to comparatively assess pathogenic, diagnostic and therapeutic issues raised in patients with the mouse model counterpart.

Indeed, producing these models meets a key objective in the development of a therapeutic strategy.