The first direct comparison of in vitro and in vivo screening techniques for identifying nanoparticles that may be used to transport
therapeutic molecules into cells shows that testing in lab dishes isn't much help in predicting...
«Comparison shows value of DNA barcoding in selecting nanoparticles: Study supports transport of
therapeutic molecules into cells.»
Not exact matches
Pardridge and his colleagues wondered if they could slip
therapeutic compounds
into the brain with the help of insulin and transferrin, a
molecule that moves iron from place to place; both insulin and transferrin are granted free passage across the blood - brain barrier.
Our team is currently developing methods that can be used to screen small
molecule inhibitors of EDD1 and also looking
into how the regulation of TIP60 levels can be translated
into therapeutic advances for the treatment of viral - mediated cancers such as cervical cancer.
Now, Salk researchers have discovered how the
molecule ERRγ gives this «healthier» brown fat its energy - expending identity, making those cells ready to warm you up when you step
into the cold, and potentially offering a new
therapeutic target for diseases related to obesity.
turned
into 10 years of systematic research to identify the enzyme PLK4 as a promising
therapeutic target and develop a small
molecule inhibitor to block it,» says Dr. Mak, Director of The Campbell Family Institute for Breast Cancer Research at the Princess Margaret Cancer Centre, University Health Network.
Next, the researchers designed
molecules called ligands to act as delivery vehicles for copper
into neuronal cells, an essential step in translating the
therapeutic action of copper to biological systems.
The ability to encapsulate small -
molecule therapeutic compounds
into vaults is critical to their development for drug delivery.
Unlike more traditional
therapeutic modalities such as small
molecules or antibodies, Neurona is focused on unique compositions of cells that can be precisely targeted, integrated
into damaged neural circuits, and provide activity - dependent regulation.