Radiation - induced pulmonary fibrosis — tissue scarring that can permanently impair lung function — limits the delivery of
therapeutic radiation doses to non-small cell lung cancer.
Not exact matches
«Randomized trials have confirmed the value of
radiation dose escalation for prostate tumors, and the potential benefits of larger
radiation doses in fewer fractions, are expected to increase the
therapeutic efficacy for men with prostate cancer,» said Anders Widmark, MD, a professor of
radiation sciences at Umeå University in Umeå, Sweden and lead author of the study.
In the largest prospective study to date, following women for 8 years post treatment, 81 women were asked to hold their breath during
radiation treatment for breast cancer - a process that was repeated until
therapeutic dose was reached.
Studies have shown that exposure of tumor cells to
therapeutic doses of
radiation activates cell survival signaling pathways such as EGFR - RAS [2 - 5] and its downstream molecules such as ERK1 / 2, PI3K - AKT, JNK, etc. apart from several other signaling molecules [4, 6, 7].
Our
radiation oncologists, who are at the forefront of research, have been leaders in developing and evaluating new
therapeutic methods that spare healthy tissue and deliver effective
doses of
radiation over a shorter period of time.
Thus apart from direct cytotoxic effect, the exposure of cancer cells to
therapeutic doses of
radiation also enhances the survival and proliferation of a fraction of cells which ultimately leads to
radiation resistance and
therapeutic inefficacy.
It utilizes a robotic arm to deliver the entire
therapeutic dose to an animal in 1 - 3 treatments, compared to conventional
radiation therapy, which can employ up to 20 treatments.