Sentences with phrase «therapeutic target molecules»
Potential therapeutic target molecules in these pathways will be highlighted in the conference.
http://www.keystonesymposia.org/ Not exact matches
«A molecular atlas of calcific aortic valve disease: Study builds molecular networks of calcific aortic valve disease to identify key molecules and therapeutic targets for a disease that affects one in four older Americans.»
New drug - delivery particles could release therapeutic molecules in the body only after they reached their targeted diseased tissues.
Since molecules that target CCR3 have already been developed by the pharmaceutical industry for other diseases, the researchers are now hoping to explore this new therapeutic pathway, which could reduce the aggressiveness of prostate cancer in obese patients.
Now, Salk researchers have discovered how the molecule ERRγ gives this «healthier» brown fat its energy - expending identity, making those cells ready to warm you up when you step into the cold, and potentially offering a new therapeutic target for diseases related to obesity.
CiRA scientists use iPS cells to show that a molecule associated with inflammation could be a therapeutic target for the abnormal bone growth.
These findings suggest that miR135 could be a useful therapeutic molecule — both as a blood test for depression and related disorders, and as a target whose levels might be raised in patients.
The researchers had assumed that the tea compound would enhance the activity of the drug Velcade, but it apparently bonded to the therapeutic molecule keeping it from binding to its true target.
«But at the same time, we are also developing a therapeutic antibody targeting annexin A2, and we are looking for a small molecule that would inhibit Sema3D.»
The computational protocol, which was validated by assembling physical peptides in the chemistry lab and comparing them to the computer models, may one day enable drug developers to craft novel, therapeutic peptides that precisely target specific disease - causing molecules within the body.
A study by the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) has found new interactions between two molecules involved in acute myeloid leukemia (AML), STAT3 and PRL - 3, which may offer a new therapeutic target for cancer treatment.
The study also points to a potentially new therapeutic target, the self - adhesion molecule P - selectin, which the researchers found played a central role in increased red blood cell adhesion.
turned into 10 years of systematic research to identify the enzyme PLK4 as a promising therapeutic target and develop a small molecule inhibitor to block it,» says Dr. Mak, Director of The Campbell Family Institute for Breast Cancer Research at the Princess Margaret Cancer Centre, University Health Network.
«Together, our findings indicate that these molecular regulators, TRIP - Br2 and GATA3, could be viable targets for small drug molecules that could serve as potential therapeutic agents against obesity,» Liew said.
The adhesion molecule CD146 plays a vital role in inflammation and offers a promising therapeutic target for treating inflammatory bowel disease (IBD) as well as preventing colitis - associated colorectal cancer, say scientists.
Most drugs exert their therapeutic effect by binding to a target protein molecule, thereby interfering with the normal function of the protein.
This enables therapeutic antibody drugs to bind with extreme precision — only their target molecule should be an exact match.
This can help identify new molecules likely to inhibit certain therapeutic targets and to lead to novel drug candidates.
AMP T2D focuses on type 2 diabetes genetics, seeking to use and supplement the substantial amount of human genetic data available from people with type 2 diabetes, or at risk of developing it, to identify and validate novel molecules and pathways as targets for therapeutic development.
The identification of disease signatures will enable screens of small molecule libraries to delineate molecular targets that modulate these disease signatures and identify new diagnostic and therapeutic leads for schizophrenia and bipolar disorder.
Currently, Schreiber and colleagues in the Broad's Center for the Science of Therapeutics focus on integrating human biology with chemistry and chemical biology to discovery small molecules that modulate therapeutic targets at the heart of disease.
Our targeted delivery adds to the specificity of our mechanism of action, with therapeutic siRNA molecules only reaching the intended target cells in the body
Using our enabling delivery systems, we have achieved an additional level of specificity by delivering our therapeutic RNA molecules exclusively to target cells.
Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma
If one could identify these molecules, they would yield information about both the basic biology of metastatic cancer and possible therapeutic targets, and that is exactly what Quigley is trying to do.
Carmot's vision is to become a leader in drug discovery by unlocking novel therapeutic target space not currently accessible to conventional small molecule technologies.
ApoE as a major causative factor and therapeutic target in Alzheimer's disease and other neurodegenerative disorders; small - molecule structure correctors to convert apoE4 to apoE3 and reverse the detrimental effects of apoE4 on mitochondria and the cytoskeleton; small - molecule protease inhibitors to block the formation of toxic fragments of apoE4; Plasma lipoprotein metabolism regulation involving apoE and apoB; cholesterol homeostasis modulation by lipoprotein receptors controlling lipoprotein clearance by the liver; Plasma HDL cholesterol (HDL - C) metabolism in the progression of atherosclerosis; the genetic epidemiology of the metabolic syndrome and low HDL - C levels established by the Turkish Heart Study.
Therefore, identifying bioactive molecules able to target the enteric nervous system, which controls the motility of intestinal smooth muscle cells, represents a new therapeutic avenue.
Unlike more traditional therapeutic modalities such as small molecules or antibodies, Neurona is focused on unique compositions of cells that can be precisely targeted, integrated into damaged neural circuits, and provide activity - dependent regulation.
We are pursuing both goals by studying the underlying biology, defining therapeutic targets, identifying active molecules by high - throughput screening and developing lead compounds.