Sentences with phrase «therapeutic targets based»
The goal of this work is to develop novel therapeutic targets based on increased understanding of the interaction of tumor cells and immune cells.
https://www.roswellpark.org/ Not exact matches
This new technology offers two main advantages based on the use of molecular tools to manipulate the genome: firstly, working models that had not existed up until now for the study of tumour biology and, secondly, their application will eventually allow for the study of new therapeutic targets and therapies.
I am sure that, on the basis of known structures, eBDIMS will be able to generate new hypotheses and will pave the way to a new generation of therapeutic targets.»
Structure - based drug design, in which the physical structure of a targeted protein is used to help identify compounds that will interact with it, has already been used to generate therapeutic agents for a number of infectious and metabolic diseases.
Based on a report published on August 20, 2015 in Nature Communications, it has been established that certain nutrients support CML stem cell activity in vivo, thus pointing towards a potential therapeutic target for CML therapy.
«Based upon this technology, we now have a greater understanding of transcriptome regulation, with potential to lead to therapeutic targets and better disease diagnostics.»
The authors, who are now planning to begin clinical trials based on this study, state that the three enzymes can be promising therapeutic targets for a diverse and broad group of DLBCL patients.
«By being able to distinguish benign from malignant aging based on distinctive RNA splicing patterns, we can develop therapeutic strategies that selectively target leukemia stem cells while sparing normal hematopoietic stem cells,» she said.
«To our knowledge,» the authors wrote, «our study is the first to explore cfDNA systematically as a means to identify therapeutic targets not detectable from standard tissue - based testing in untreated metastatic disease.»
A $ 1.7 million drug discovery effort to identify molecular and genetic risk factors and new therapeutic targets for cognitive decline and Alzheimer's disease, based on data from the Religious Order Study and the Rush Memory and Aging Project.
«We want to contribute to identifying new targets of attack that could serve as a basis for the development of therapeutic or diagnostic approaches,» explains group leader Suttner.
In preliminary findings presented at the 2016 San Antonio Breast Cancer Symposium, researchers showed that older patients were as likely as younger patients to receive targeted therapy and enroll in therapeutic trials based on their sequencing results.
Synthetic lethality - based strategy has been developed to identify therapeutic targets in cancer harboring tumor suppressor gene mutations, as exemplified by the effectiveness of PARP inhibitors in BRCA1 / 2 - mutated tumors.
Translation of these fundamental discoveries has enabled gene - based diagnosis and novel therapeutic targets.
The advancement of the Cas9 - based platform for screening and validation will help further the development of new therapeutic products, and Caribou's CRISPR - Cas9 technology can utilize guide RNAs specific for unique sequences and target a gene at numerous sites and therefore provide enhanced specificity.
iTeos and Adimab LLC are collaborating on the discovery, development and commercialization of multiple, antibody - based therapeutic programs, with Adimab using its antibody discovery and optimization platform to identify fully human therapeutic antibodies against targets selected by iTeos.
The Cell Surface Signalling Laboratory investigates the molecular basis of cellular recognition processes to identify new therapeutic targets for both genetic and infectious diseases.
Relevant publications: (1) Drug repurposing, computer - based screening (2) Functional testing and novel tools for bioapplications (3) Therapeutic targets and disease pathways by bioinformatic analysis
Aptamer - Based Therapeutic Approaches to Target Cancer Stem Cells Gang Zhou, Olivier Latchoumanin, Mary Bagdesar, Lionel Hebbard, Wei Duan, Christopher Liddle, Jacob George, Liang Qiao Theranostics 2017; 7:3948 - 3961
Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma
However, a great deal of basic research is still required to understand the molecular bases of rare diseases and identify potential therapeutic targets.
Introducing new DNA often is achieved by viral transduction of target cells with a therapeutic transgene, through either a direct or cell - based gene therapy modality.
Together, these data define METTL3 as a regulator of a chromatin - based pathway that is necessary for maintenance of the leukaemic state and identify this enzyme as a potential therapeutic target for acute myeloid leukaemia.
Deciphering cell signaling, especially for G - protein coupled receptors (GPCRs), forms the basis of discovering therapeutic targets.
Responsible for planning and achieving the marketing goals and sales targets of all therapeutic areas on a monthly basis
Intensive, long - term, early intervention support for children, young people and their families which may include: assessment and identification of needs; practical assistance and home - based support; linking with other relevant services; and, targeted therapeutic groups.