Sentences with phrase «therapeutic targets for»
Potential therapeutic targets for neurodegenerative diseases: lessons learned from calorie restriction.
http://www.ballingerathleticperformance.com/
Besides enabling patient stratification, our study allows the identification of novel therapeutic targets for obesity.
72/3: 45 Systems genetics approach unravels the molecular mechanisms underlying lung function variation and uncovers novel therapeutic targets for COPD.
Emerging studies on brain - derived neurotrophic factor (BDNF) have shown that might be novel biomarkers and therapeutic targets for cancer.
The finding presented new therapeutic targets for upregulating CMA activity.
Emerging studies suggest that miRs are novel therapeutic targets for complex diseases.
«By finding out what is altered in TGF - β and other signaling pathways, we hope to identify better therapeutic targets for the treatment or even prevention of HD.»
Generating mouse models to validate telomeres and telomerase as therapeutic targets for cancer and age - related diseases.
A handful of those genes have a common mechanism of regulation and may be good therapeutic targets for drug discovery.
The results of our studies should identify potential mechanisms underlying the white matter abnormalities seen in many degenerative diseases, and may reveal novel therapeutic targets for regenerative medicine.
It has invested more than $ 450 million in research to date, almost 90 percent for translational research; funded testing of more than 100 therapeutic targets for Parkinson's disease (PD); and has undertaken novel industry partnerships to support early - stage promising therapeutic approaches.
These findings establish Frizzled family receptors as disease - relevant receptors for toxin B in the colonic epithelium and provide novel therapeutic targets for treating C. difficile infections.
«We think this development will help other scientists better utilize open data, hopefully leading to the discovery of new therapeutic targets for disease,» says first author Andra Waagmeester, PhD, formerly a researcher at Maastricht University and now CEO of the start - up company Micelio.
«This perspective will offer us a window into new therapeutic targets for these diseases.»
The Cell Surface Signalling Laboratory investigates the molecular basis of cellular recognition processes to identify new therapeutic targets for both genetic and infectious diseases.
Our work decoding new components of the energy - sensing pathway has also led to new therapeutic targets for many difference forms of cancer, which alter these same pathways through many different mechanisms.»
The Cell Surface Signalling Laboratory is interested in identifying new therapeutic targets for both genetic and infectious diseases by using large - scale systematic approaches to discover receptor - ligand interactions that are essential for cellular recognition processes.
Our aim is to highlight the genetic networks that can impact on DM1 biomarkers to provide new therapeutic targets for treatments by chemical compounds.
This technology helps researchers connect mutations in the so - called genomic «dark matter» with the genes they affect, potentially revealing new therapeutic targets for genetic disorders.
This has prevented the identification of potential therapeutic targets for clinical intervention.
Future investigations on the postsynaptic role of p - tau will be necessary to understand its toxic effects and provide insights into new therapeutic targets for maintaining spine integrity, highlighting the importance of tau toxicity as well as the impact of sex on tau - pathology.
This study may provide a potential biomarker and therapeutic targets for glaucoma.
These results suggest that miR - 7 and KLF4 may serve as biomarkers or therapeutic targets for brain metastasis of breast cancer.
An international study led by researchers at Monash University» Biomedicine Discovery Institute (BDI) has shone light on the way the Hepatitis C Virus (HCV) hijacks the communication systems in the host cells it infects, uncovering potential new therapeutic targets for the disease.
Despite this clinical importance, the exact pathologic process of tumor metastasis is as yet poorly understood, and deciphering the exact molecular mechanism of this process is of paramount importance to identify specific therapeutic targets for this devastating disease.
«It would be amazing if we could use these differences in collagen patterns to help discover new therapeutic targets for this devastating disease.»
«While we need to better understand how these abnormally regulated metabolites activate oncogenic proteins, our intriguing discovery suggests novel therapeutic targets for this disease,» says principal investigator and study leader Arnab Chakravarti, MD, chair and professor of Radiation Oncology and co-director of the Brain Tumor Program at the OSUCCC — James.
«The LINK - A dependent HIF1 signalizing cascade and the consequent effects on cancer cells implicate LINK - A and LINK - A interacting kinases and receptors as promising therapeutic targets for TNBC.»
Not only could this could ultimately help predict an individual's response to weight loss intervention, but it may offer therapeutic targets for enhancing a weight loss program's effects.
Further exploration of the TCA cycle, using metabolomics, may identify novel therapeutic targets for CKD and in turn may help us evaluate the effects of promising interventions.»
A $ 1.7 million drug discovery effort to identify molecular and genetic risk factors and new therapeutic targets for cognitive decline and Alzheimer's disease, based on data from the Religious Order Study and the Rush Memory and Aging Project.
Genetic deletion causes obsessive - compulsive disorder in a mouse, suggesting therapeutic targets for counteracting the syndrome
Professor Andrew Lotery, who led the Southampton contribution, hopes the findings may help improve the understanding of the biological processes that lead to AMD and identify new therapeutic targets for potential drug development.
«The induced pluripotent stem cells we used in this study proved to be extremely useful in disease modelling, and they could offer an excellent platform for drug discovery and testing new therapeutic targets for Alzheimer's disease in the future,» says Early Stage Researcher Minna Oksanen, the lead author of the study.
The authors, who are now planning to begin clinical trials based on this study, state that the three enzymes can be promising therapeutic targets for a diverse and broad group of DLBCL patients.
The researchers hope that a better understanding of how Ras proteins cluster together and interact with other proteins in cells will bring them one step closer to developing therapeutic targets for Ras - driven tumors.
«This makes it important to identify new therapeutic targets for the development of effective treatments,» the investigators conclude.
A better understanding of the function of neuromodulators, such as COX - 2 and TIA - 1, may help identify novel therapeutic targets for the treatment of epilepsy.»
Remarkably, when the researchers manipulated the activity of these three genes, almost all of the other genes in the network were corrected, pointing to novel therapeutic targets for CAVD.
«This provides strong evidence that Müller glia are important therapeutic targets for treating degenerative eye diseases,» said Sehwon Koh, Ph.D., who is the lead author of this paper and a postdoctoral fellow in the laboratory of Cagla Eroglu, Ph.D., an associate professor of cell biology and neurobiology at the Duke University Medical Center.
The authors conclude that these genes may represent new therapeutic targets for HD.
«A molecular atlas of calcific aortic valve disease: Study builds molecular networks of calcific aortic valve disease to identify key molecules and therapeutic targets for a disease that affects one in four older Americans.»
A protein known as arginine methyltransferase 1 (PRMT1) may be a potential therapeutic target for pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, and one of the most deadliest with a less than 10 percent, five - year survival rate.
This study provides evidence of a direct effect of AMPK on nicotine withdrawal symptoms and suggests that activating AMPK in the brain could be a therapeutic target for smoking cessation.
«Potential therapeutic target for deadly brain cancer.»
«New therapeutic target for Huntington's disease.»
Abnormal BMIPP identifies specific myocardial injury which could be an effective therapeutic target for preventing sudden cardiac death.»
The observed increase in the biomarker for itch (IL - 31) in skin points to another useful therapeutic target for children.
Now, Salk researchers have discovered how the molecule ERRγ gives this «healthier» brown fat its energy - expending identity, making those cells ready to warm you up when you step into the cold, and potentially offering a new therapeutic target for diseases related to obesity.
Based on a report published on August 20, 2015 in Nature Communications, it has been established that certain nutrients support CML stem cell activity in vivo, thus pointing towards a potential therapeutic target for CML therapy.