Sentences with phrase «therapeutic targets in»
«Establishing reference intervals for estimated [systolic blood pressure] in healthy cats using Doppler or oscillometric equipment is fundamental to the clinical diagnosis of hypertension, and also for determining therapeutic targets in affected cats.»
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My laboratory aims to identify, characterize and validate lncRNA - driven pathways active in allergy - driving helper T cells and airway epithelial cells that could hold promise as therapeutic targets in altering the aberrant immune responses underlying asthma.
Dr. Beauchamp's primary area of research interest has been in colorectal carcinogenesis, the biology of cancer cell invasion and metastasis, and in the identification of novel molecular biomarkers and therapeutic targets in colorectal and other alimentary tract malignancies.
These proteins, if their roles in neuroprotection in the retina are fully established in the future by more comprehensive studies, may present novel therapeutic targets in treating retinal disorders including glaucomatous conditions.»
Because of the ease with which the CRISPR / Cas9 system can be applied, it has quickly become a robust tool for generating accurate genetic disease models in the laboratory and for identifying novel therapeutic targets in the clinic.
The ultimate goal of this work is to identify therapeutic targets in both the heart and spinal cord....
The Research Training Group «Targets in Toxicology - Deciphering Therapeutic Targets in Lung Toxicology» is a newly founded structured Ph.D. program which brings together twelve research partners in the Munich region in Germany.
Synthetic lethality - based strategy has been developed to identify therapeutic targets in cancer harboring tumor suppressor gene mutations, as exemplified by the effectiveness of PARP inhibitors in BRCA1 / 2 - mutated tumors.
We're hopeful that our findings will eventually open a new pathway for therapeutic targets in this form of cancer.»
«Triple - negative breast cancer continues to be a severe health problem, demanding the consideration of emerging long non-coding RNAs as biomarkers and therapeutic targets in combatting this disease,» said Liquing Yang, Ph.D., assistant professor in the Department of Molecular & Cellular Oncology.
Research fields are diverse, including basic research on cell proliferation, analysis of tumour cells and tissues to detect gene mutations, and identification of potential therapeutic targets in cancer.
This can teach us which factors play a role in infection and those could be therapeutic targets in the future.»
A new method has been found for identifying therapeutic targets in cancers lacking specific key tumor suppressor genes.
«StimDust is the smallest deep - tissue stimulator that we are aware of that's capable of stimulating almost all of the major therapeutic targets in the peripheral nervous system,» said Rikky Muller, co-lead of the work and assistant professor of electrical engineering and computer sciences at Berkeley.
Our work suggests that studying PI (3,4) P2 - regulated processes may reveal why PTEN is such a powerful tumour suppressor and may also help us to identify new therapeutic targets in PTEN - mutated cancers.»
«PI3K protein: Potential new therapeutic target in pancreatic neuroendocrine tumors.»
Further investigation uncovered CHD1's role as vital to PTEN signaling, and as a potential therapeutic target in prostate and breast cancers with PTEN gene loss.
Therefore, correction of iron deficiency itself should be considered an attractive therapeutic target in this population.»
These results not only suggest early mitochondrial biogenesis deficits as a pathogenic mechanism, but also as a potential biomarker and therapeutic target in individuals with Friedreich's ataxia.
Researchers found that levels of neurotrophic factor (BDNF) nearly doubled in the brains of vulnerable mice, a finding that could point to a therapeutic target in humans for combating post-traumatic stress disorder and depression.
Dario C. Altieri, M.D., Wistar's President and CEO and lead author of the study, and colleagues showed how the activation of this pathway leads to an unfavorable prognosis for patients with gliomas — a type of brain tumor — and how the pathway could be a valuable therapeutic target in cancer.
New studies from the Abramson Cancer Center of the University of Pennsylvania are providing fresh clues on potentially effective combinations with CAR T therapy in brain cancer as well as a novel therapeutic target in head and neck cancer, and also providing greater understanding of the mechanisms of resistance in pancreatic cancer.
Defective HR is an important therapeutic target in EOC as exemplified by the efficacy of platinum analogues in this disease, as well as the advent of PARP inhibitors, which exhibit synthetic lethality when applied to HR - deficient cells.
These findings highlight the potential of Nav1.1 and inhibitory interneurons as a therapeutic target in AD and that disease - specific molecular optimization of cell transplants may be required to ensure therapeutic benefits in different conditions.
A mini-review of c - Met as a potential therapeutic target in melanoma.
These findings suggest that activation of mTOR signaling contributes to tumor cell survival in ALK + ALCL, thus providing a potential therapeutic target in this lymphoma type.
KIT as a therapeutic target in metastatic melanoma.
«Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer»
Ultimately, the center's goal will be to control these circuits through therapeutic targeting in a variety of biological systems, including cellular reprogramming, neuroscience, cancer, and infectious disease.
SMYD2 could therefore be used as a therapeutic target in the shock and kill strategy.»
- Gut Flora as a Participant and Therapeutic Target in Cardiovascular Disease; Stanley Hazen, Cleveland Clinic.
ApoE as a major causative factor and therapeutic target in Alzheimer's disease and other neurodegenerative disorders; small - molecule structure correctors to convert apoE4 to apoE3 and reverse the detrimental effects of apoE4 on mitochondria and the cytoskeleton; small - molecule protease inhibitors to block the formation of toxic fragments of apoE4; Plasma lipoprotein metabolism regulation involving apoE and apoB; cholesterol homeostasis modulation by lipoprotein receptors controlling lipoprotein clearance by the liver; Plasma HDL cholesterol (HDL - C) metabolism in the progression of atherosclerosis; the genetic epidemiology of the metabolic syndrome and low HDL - C levels established by the Turkish Heart Study.
Gut Flora as a Participant and Therapeutic Target in Cardiovascular Disease; Stanley Hazen, Cleveland Clinic.
Myelosuppression is a well - established side effect of current AML therapies, with prolonged events leading to an increased risk of infections and death.44 Consequently, therapies that preferentially kill leukemic cells over normal bone marrow cells are urgently required, and the overexpression of CD123 on AML leukemic stem cells and blasts compared with normal hematopoietic cells contributes to its attractiveness as a therapeutic target in this disease.6, 45 However, severe myelosuppression and myeloablation have emerged for some investigational CD123 - targeted treatment modalities.
Nrf2 / ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS.
Not exact matches
«SiteOne's therapeutic candidates exhibit impressive potency and selectivity for NaV1.7, and engage the target in a way that differentiates them from other inhibitors of Nav1.7.
The concept of using the immune system as a therapeutic is not new, but our ability to use the immune system to target things we're interested in is novel.
Researchers hope the organoids will be better than lab animals or cells growing in culture at revealing how the human brain develops, both normally and when things go awry, and identify potential therapeutic or genome - editing targets.
Such clear differences in biomarker signatures are an important step in identifying new disease markers, and perhaps therapeutic targets.
Szmydynger - Chodobska said the team is also interested in looking at the proteins as therapeutic targets.
«A molecular atlas of calcific aortic valve disease: Study builds molecular networks of calcific aortic valve disease to identify key molecules and therapeutic targets for a disease that affects one in four older Americans.»
New drug - delivery particles could release therapeutic molecules in the body only after they reached their targeted diseased tissues.
Richard Hargreaves, executive director of imaging at Merck Research Laboratories, says, «Nuclear imaging using radiotracers gives the opportunity to put your arms around proof - of - concept very early in a drug discovery and development program by focusing the selection of doses to study on those proven to deliver enough drug to the target therapeutic sites.»
This study provides evidence of a direct effect of AMPK on nicotine withdrawal symptoms and suggests that activating AMPK in the brain could be a therapeutic target for smoking cessation.
«Targeting the drivers of aging and senescent cells may be a novel therapeutic strategy to reduce hepatic steatosis and liver fibrosis in ALD patients,» commented co-author Gianfranco Alpini, PhD, Distinguished Professor in the Department of Medical Physiology at Texas A&M College of Medicine, Senior Research Scientist at Central Texas Veterans Health Care System, and Director of the BSW DDRC.
The findings by a team of Massachusetts General Hospital (MGH) investigators, which will be published in the April 24 issue of Cell and are receiving advance online release, support the importance of epigenetics — processes controlling whether or not genes are expressed — in cancer pathology and identify molecular circuits that may be targeted by new therapeutic approaches.
«Excitement in the brown fat field has risen significantly over last few years because its energy - burning nature makes it a potential therapeutic target against obesity and diabetes,» said Dr Lee.
«They also suggest that low - dose metronomic chemotherapy or targeting the chemokine signaling mediated by chemo - treated fibroblasts may improve the therapeutic outcome in desmoplastic cancers.»
By hitting breast cancer cells with a targeted therapeutic immediately after chemotherapy, researchers from Brigham and Women's Hospital (BWH) were able to target cancer cells during a transitional stage when they were most vulnerable, killing cells and shrinking tumors in the lab and in pre-clinical models.
Given the importance of ATP synthase in fueling the cell, determining the complete structure of the enzyme has been a scientific holy grail, promising to reveal secrets about the ATP machine that could lead to therapeutic target identification and advance understanding of metabolic disease and other cellular pathologies.