Sentences with phrase «therapeutic targets not»

«To our knowledge,» the authors wrote, «our study is the first to explore cfDNA systematically as a means to identify therapeutic targets not detectable from standard tissue - based testing in untreated metastatic disease.»

Not exact matches

The concept of using the immune system as a therapeutic is not new, but our ability to use the immune system to target things we're interested in is novel.

The findings by a team of Massachusetts General Hospital (MGH) investigators, which will be published in the April 24 issue of Cell and are receiving advance online release, support the importance of epigenetics — processes controlling whether or not genes are expressed — in cancer pathology and identify molecular circuits that may be targeted by new therapeutic approaches.

This new technology offers two main advantages based on the use of molecular tools to manipulate the genome: firstly, working models that had not existed up until now for the study of tumour biology and, secondly, their application will eventually allow for the study of new therapeutic targets and therapies.

«CRMP1 was not regarded as a therapeutic target so far, now it is worth exploring as a potential target,» said Wanker.

«And while the tumor model we're now studying doesn't present targets for new drugs, if we can discover the mechanism controlling that model, it may yield therapeutic drug targets.»

«We wanted to identify some potential therapeutic targets that are common not just to one but to multiple forms of retinitis pigmentosa at late - stage disease, when it is more likely to be clinically diagnosed in a patient population.»

«Our research shows that targeting cannabinoid receptors in the periphery with pharmacological inhibitors that do not reach the brain holds promise as a safe therapeutic approach for the treatment of overeating and diet - induced obesity,» said Nicholas V. DiPatrizio, an assistant professor of biomedical sciences in the School of Medicine, who led the research project.

That doesn't mean patients should stop treatment, caution the authors, who call these robust survivor cells a new therapeutic target.

This ability to persist makes them not only an interesting therapeutic target, but also a potential molecular beacon or biomarker that can facilitate the diagnosis of disease.

The findings, made in mice, explain why most but not all motor neurons are affected by the disease and identify a potential therapeutic target for this still - incurable neurodegenerative disease.

These results not only suggest early mitochondrial biogenesis deficits as a pathogenic mechanism, but also as a potential biomarker and therapeutic target in individuals with Friedreich's ataxia.

In a new study, published online June 6 in Nature, researchers at University of California San Diego School of Medicine and Moores Cancer Center, together with colleagues at Keio University, the University of Nebraska and Ionis Pharmaceuticals describe an innovative new model that not only allowed them to track drug resistance in vivo, but also revealed a new therapeutic target, which early testing suggests could provide a strategy to arrest pancreatic cancer growth.

If we can show that this anomaly doesn't occur in healthy cells, we will be able to think about exploring these structures as possible therapeutic targets.»

The second branch of the combination therapy, the low - dose metronomic chemotherapy, was similarly found to exert its therapeutic effect through a novel, hitherto unrecognized mechanism: The metronomic chemotherapy turned out to not primarily target the tumor cells, but to act on the recruitment of yet another tumor - promoting cell population from the bone marrow.

Not only could this could ultimately help predict an individual's response to weight loss intervention, but it may offer therapeutic targets for enhancing a weight loss program's effects.

Second, these regulatory determinants may not always be obvious from reductionist principles, and, thus, the analysis provides unique insight into disease mechanism and potential therapeutic targets.

Defining the network interactions among these modular elements (and their probabilistic relationships, where appropriate) not only will account for the ultimate pathophenotype but also can lead to the identification of potential regulatory nodes within the network that can modify phenotype (i.e., potential therapeutic target).

This model may still be correct, but the therapeutic mechanism may not solely be due to EC targeting effects.

We believe that leveraging human intuition through creation of a scientific game for drug discovery can not only provide a new avenue to discover therapeutic drugs for protein targets, but can also contribute to the development of new sophisticated algorithms to use in computer aided drug design.

«Our data not only validate TRK fusions as therapeutic targets but also show that they lead to tumor - agnostic sensitivity to larotrectinib,» the authors wrote.

Establishing the role of cigarette smoke in progression of cancer will not only produce the necessary evidence for implementing smoking cessation interventions but may also help to identify cellular mechanisms for therapeutic targeting.

«The inflammation resolving targeted nanoparticles have shown exciting potential not only for the potential treatment of atherosclerosis as described here, but also other therapeutic areas including wound repair, for example, as described in the Feb. 9 online issue of Journal of Clinical Investigation, in addition to other applications currently underway with our collaborators,» Farokhzad said.

Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5

In contrast, no difference was observed in the sensitivity of these cell lines to cytosine arabinoside (ARA - C), a standard chemo - therapeutic drug which targets different pathways (data not shown).

Tran T, De Oliveira Diniz M, Dransart E, Gey A, Merillon N, Lone YC, Godefroy S, Sibley C, Ferreira LC, Medioni J, Oudard S, Johannes * L, Tartour * E (2016) A therapeutic Her2 / neu vaccine targeting dendritic cells preferentially inhibits the growth of low Her2 / neu - expressing tumor in HLA - A2 transgenic mice.

Under normal conditions, deletion of the transporter does not lead to any noticeable phenotype, suggesting that pharmacological or biological blockade of the transporter for therapeutic purposes is not likely to elicit significant off - target effects in normal tissues.

Despite this generally well - accepted idea for how high eye pressure may affect RGC axons, scientists still do not understand the injury mechanisms involved in sufficient detail to begin identifying potential therapeutic targets.

Carmot's vision is to become a leader in drug discovery by unlocking novel therapeutic target space not currently accessible to conventional small molecule technologies.

We hypothesized that antimicrobial resistance can be reversed by targeting chromosomal non-essential genes that are not responsible for acquired resistance but essential for resistant bacteria under therapeutic concentrations of antimicrobials.

«In order to find other therapeutic targets you have to find something that you can actually hit, but NRF2 has a protein half - life of like 20 minutes, so you don't have a large window to target that protein.

Keiichiro Suzuki, a CRISPR expert from Salk Institute researcher, also not involved in the study, said by email: «Due to the high stability, specificity and ease for biosynthesis, the synthetic CRISPR RNA approach developed in this study will facilitate targeted genetic modification in a variety of human cells for fundamental studies as well as therapeutic applications»

According to the researchers, therapeutic interventions are generally targeted at improving joint function and minimizing pain by making use of therapies that focus on symptoms, but don't assist joint structure improvement or long term improvement of the disease.

Therefore, not only is it important to give an antibiotic that will treat a particular bacterial infection, it is equally important that the correct amount be given in order to reach the targeted tissue at a therapeutic level.

At minimum the report should include the assessment (from patient or independent rater perspective, not therapist) of at least two standardized outcome measures, global functioning and target symptom (i.e. depression, anxiety, etc), as well as one process measure (i.e. therapeutic alliance, session depth, emotional experiencing, etc) evaluated on at least three separate occasions.