Sentences with phrase «therapeutic targets with»
«Since neurotrophins and their receptors control the communication between the brain and peripheral organs, they could be new therapeutic targets with implications in both metabolic and neurologic diseases.»
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«Because of its different origin, this enzyme could represent a good therapeutic target with selective action against all apicomplexans,» adds Luis Izquierdo, ISGlobal researcher and coordinator of the study.
«Our findings have important translational value since they establish this protein enzyme as a novel and viable therapeutic target with real disease - modifying potential for AD,» Praticò said.
Not exact matches
A protein known as arginine methyltransferase 1 (PRMT1) may be a potential therapeutic target for pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, and one of the most deadliest with a less than 10 percent, five - year survival rate.
The work demonstrates that even with the clinical successes of blocking PD - 1, there may be a better, more refined therapeutic strategy to target the PD - 1 pathway.
By hitting breast cancer cells with a targeted therapeutic immediately after chemotherapy, researchers from Brigham and Women's Hospital (BWH) were able to target cancer cells during a transitional stage when they were most vulnerable, killing cells and shrinking tumors in the lab and in pre-clinical models.
By hitting breast cancer cells with a targeted therapeutic immediately after chemotherapy, researchers were able to target cancer cells during a transitional stage when they were most vulnerable.
Structure - based drug design, in which the physical structure of a targeted protein is used to help identify compounds that will interact with it, has already been used to generate therapeutic agents for a number of infectious and metabolic diseases.
The results show TREX2 as a potential therapeutic target to tackle this disease with a different and more focused strategy.
The continuation of this line of research is opening new avenues to identify what specific signals are used to promote this increased neurogenic response, with views focused in targeting neurogenesis as a therapeutic approach to promote the regeneration of lost neurons.»
University of Calgary researchers including Luchman, Weiss and Dr. Greg Cairncross — director of SACRI, and leader of the Terry Fox Research Institute (TFRI) «Therapeutic Targeting of Glioblastoma research program at the university — are now working with cancer researchers Dr. Warren Mason (Princess Margaret Cancer Centre in Toronto) and Dr. Lesley Seymour (Director of the NCIC Clinical Trials Group's Investigational New Drug Program), and drug manufacturer AstraZeneca, to plan a clinical trial testing a similar, but newer, drug related to AZD8055 (called AZD2014), in combination with TMZ, in patients with glioblastoma.
«New therapeutic target for a type of colorectal cancer with poor prognosis has been identified.»
CiRA scientists use iPS cells to show that a molecule associated with inflammation could be a therapeutic target for the abnormal bone growth.
«Perhaps supplementing the diet of obese pregnant mothers with PQQ, which has proven safe in several human studies, will be a therapeutic target worthy of more study in the battle to reduce the risk of NAFLD in babies,» Jonscher said.
«Our research shows that targeting cannabinoid receptors in the periphery with pharmacological inhibitors that do not reach the brain holds promise as a safe therapeutic approach for the treatment of overeating and diet - induced obesity,» said Nicholas V. DiPatrizio, an assistant professor of biomedical sciences in the School of Medicine, who led the research project.
«This finding suggests a novel therapeutic target to decrease invasion of tumor cells in patients and may also provide a novel biomarker that could help predict survival of patients with glioblastoma,» explained Israel.
«Based upon this technology, we now have a greater understanding of transcriptome regulation, with potential to lead to therapeutic targets and better disease diagnostics.»
It could be a critical target with significant therapeutic potential for suppressing inflammation associated with chronic airway disease.
Further investigation uncovered CHD1's role as vital to PTEN signaling, and as a potential therapeutic target in prostate and breast cancers with PTEN gene loss.
Altered sphingolipid levels in blood have been associated with depression and have been proposed as a therapeutic target for major depressive disorder.
«This is relevant to a variety of diseases associated with chronic inflammation, including cancer, and could yield new therapeutic targets.»
The researchers hope that a better understanding of how Ras proteins cluster together and interact with other proteins in cells will bring them one step closer to developing therapeutic targets for Ras - driven tumors.
During the last three years the Spanish Consortium for the Study of the Genome of the Chronic Lymphatic Leukemia, where the researchers of the present study already collaborate, has sequenced the genome of hundreds of patients with the more common leukemia in our society, identifying new mechanisms of tumor progression and new therapeutic targets.
With their new data in hand, the researchers are pursuing three possible therapeutic targets to stop pancreatic cancer metastasis driven by annexin A2 and Sema3D.
«These findings could lead to a new therapeutic strategy for patients with AML and potentially other diseases by targeting patients whose leukemia cells display activation of a specific survival pathway.»
The team is currently looking into methods to target the STAT3 - PRL - 3 pathway in AML, which could open up new avenues to treat AML patients with high expression of PRL - 3 and offer an attractive anti-leukemia therapeutic strategy.
Therefore, BCAR4 may be a potential therapeutic target for cervical cancers with this alteration.
An emerging controller of the cholinergic effect of inflammation is micro-RNA-132 (5), whose involvement with post-stroke recovery awaits further studies and might open new venues for more rigorous assessment of the post-stroke risk of survival and systematic infection and the identification of conceptually novel targets for therapeutic interference.
«This breakthrough could lead to more effective therapies for women with this very common subtype of breast cancer and be the therapeutic target that the drug companies have been waiting for.»
Most importantly for individuals with FOP, the study identifies HIF - 1α as a therapeutic target — knowledge that will likely contribute to the development of more effective treatments for FOP and related common disorders of heterotopic ossification.
The CUMC team is currently using the new mouse model to study signaling pathways in the brain that drive anorexic behavior, with the ultimate goal of identifying therapeutic targets.
These results not only suggest early mitochondrial biogenesis deficits as a pathogenic mechanism, but also as a potential biomarker and therapeutic target in individuals with Friedreich's ataxia.
Hajishengallis, Chavakis and their colleagues identified the protein on hematopoetic stem cells with which Del - 1 interacts, the ß3 integrin, perhaps pointing to a target for therapeutic interventions down the line.
In a new study, published online June 6 in Nature, researchers at University of California San Diego School of Medicine and Moores Cancer Center, together with colleagues at Keio University, the University of Nebraska and Ionis Pharmaceuticals describe an innovative new model that not only allowed them to track drug resistance in vivo, but also revealed a new therapeutic target, which early testing suggests could provide a strategy to arrest pancreatic cancer growth.
«Targeting this inflammatory pathway with drugs or antibodies could be a new therapeutic strategy to treat worm infections and the associated pathology,» said Meera Nair, an assistant professor of biomedical sciences in the UC Riverside School of Medicine, whose laboratory made the discovery.
«Given the therapeutic potential of the nSMase target, we're now working closely with Drs. Barbara Slusher, Camilo Rojas, Ajit Thomas and colleagues at the Johns Hopkins Drug Discovery facility to identify potent inhibitors of the nSMase enzyme which can be developed for clinical use,» says Haughey.
«Future studies on how PAF / PAFR signaling controls UCP1 levels through beta3 - AR production in the BAT of animals and humans may reveal new therapeutic targets to treat metabolic disorders associated with obesity,» said Junko Sugatani, Ph.D., a researcher involved in the work from the Department of Pharmaco - Biochemistry at the School of Pharmaceutical Sciences at the University of Shizuoka in Shizuoka, Japan.
Although far more work needs to be done before bringing it to the clinic, targeting CD146 with AA98, especially in combination with an anti-TNF-alpha antibody, may be a therapeutic option in treating colitis, as well as a preventative method for CAC.»
The artificial receptor acts as a lure for the B cells that target Dsg3, bringing them into fatal contact with the therapeutic T cells.
Most drugs exert their therapeutic effect by binding to a target protein molecule, thereby interfering with the normal function of the protein.
«With TEK, we know exactly what's going wrong, which means we've identified a pathway that could be a great new therapeutic target for severe glaucoma and even more common forms of the disease.»
Dario C. Altieri, M.D., Wistar's President and CEO and lead author of the study, and colleagues showed how the activation of this pathway leads to an unfavorable prognosis for patients with gliomas — a type of brain tumor — and how the pathway could be a valuable therapeutic target in cancer.
«Silent seizures recorded in the hippocampus of two patients with Alzheimer's disease: Seizure - like activity in key memory structure may contribute to cognitive symptoms, offering new therapeutic target.»
One problem with these drugs, however, is that they often inhibit many different targets, which can lead to side effects and complications in therapeutic use.
The team also discovered new pockets in the HNF - 4α protein that could be targeted with therapeutic drugs.
New studies from the Abramson Cancer Center of the University of Pennsylvania are providing fresh clues on potentially effective combinations with CAR T therapy in brain cancer as well as a novel therapeutic target in head and neck cancer, and also providing greater understanding of the mechanisms of resistance in pancreatic cancer.
«While the road to heparanase - targeting clinical drugs is long and fraught with risks, with this work we believe to have taken a major step in realising the therapeutic potential of this promising clinical target.»
«This genomic information will provide the research community with a powerful tool for uncovering new therapeutic targets and developing better strategies for diagnosing, treating and preventing cancer.»
«Single enzyme with the power of three could offer shortcut to therapeutic target.»
Importantly, this association of disease with functional modules can also inform our choice of rational therapeutic targets.