Sentences with phrase «therapeutic uses of stem cells»

However, with few exceptions, the stem cell and regenerative medicine industry has remained inadequately capitalized to carry out large - scale clinical trials independently, and major pharmaceutical firms have tended to show more interest in the use of hiPSCs as a source of large, pure populations of specific somatic cells for use in drug compound screening and toxicology tests, than they have in therapeutic uses of stem cells and their derivatives.

The therapeutic use of stem cells is a promising area of medicine for the decades ahead and researchers are examining why stem cells function in certain types of niches, microenvironments, and pockets of activity.

This model, he said, could have important implications for the therapeutic use of stem cells to rejuvenate damaged tissues.

Dr. Huard is an internationally recognized cell biologist conducting laboratory research into the therapeutic use of stem cells to treat a variety of musculoskeletal and orthopaedic diseases and injuries.

Not exact matches

If ESCR using «excess» embryos from IVE» continues, the next step will likely be the pursuit of such «therapeutic» cloning — the creation of embryos through somatic cell nuclear transfer (SCNT) to provide individually tailored stem cell therapies.

«The hope is that ZPF217 could be used to maintain supplies of therapeutic stem cells,» said lead study author Martin Walsh, PhD, Associate Professor of Pediatrics, Structural and Chemical Biology, and Genetics and Genomic Sciences of the Icahn School of Medicine at Mount Sinai.

To solve this, West proposed «therapeutic cloning» — taking the nucleus out of a patient's cell, transferring it into an egg cell to create a cloned embryo, then using that embryo to derive patient - matched stem - cell lines.

Also limiting the use of therapeutic stem cells to date, self - renewal, a quality so vital to a fast - growing fetus, can also be a source of cancer risk when haphazard, unlimited cell multiplication results in the abnormal tissue growth seen in tumors.

A therapeutic screening center, headed by Lee Rubin at the Harvard Department of Stem Cell and Regenerative Biology, is dedicated to using induced pluripotent stem cells to find new drugs for genetic diseaStem Cell and Regenerative Biology, is dedicated to using induced pluripotent stem cells to find new drugs for genetic diseastem cells to find new drugs for genetic diseases.

The authors conclude that mesenchymal stem cell therapy has great potential as a therapeutic option in feline disease, but that many questions about the logistics of its use remain to be answered.

«It is imperative to better understand the biology of hMSCs, to best expand them and use them in future therapeutic applications,» noted Dr. Jan Nolta, Editor in Chief of STEM CELLS.

«This work provides a proof of principle for using stem cell - derived human intestinal organoids in a therapeutic setting.»

A new study in mice published in The Journal of Neuroscience details a potential therapeutic strategy that uses stem cells to promote recovery of motor activity after spinal cord injury.

«The induced pluripotent stem cells we used in this study proved to be extremely useful in disease modelling, and they could offer an excellent platform for drug discovery and testing new therapeutic targets for Alzheimer's disease in the future,» says Early Stage Researcher Minna Oksanen, the lead author of the study.

To address these limitations, Zimmer and senior study author Lorenz Studer of the Sloan Kettering Institute for Cancer Research developed a simple, efficient, and robust stem cell - based strategy for reliably producing a large number of diverse, functional pituitary cell types suitable for therapeutic use.

In turn this could lead to the realistic prospect of using SCNT to generate stem cells for therapeutic purposes in humans as well as generating transgenic animals that are healthy, fertile and productive.

This is what makes the return of therapeutic cloning such a gripping plot twist (see «Human stem cells made using Dolly cloning technique «-RRB-.

Researchers say the finding places important restrictions on the potential therapeutic use of neural stem cells.

With so much work needed in studying the nature of stem cells and using them to study disease processes, therapies based on ES cells seem very far down the line, noted Lorenz Studer of Memorial Sloan - Kettering Cancer Center in New York, who pointed out that so far there have only been two published papers on therapeutic cloning, both of them in mice.

However, these problems associated with histocompatibility may be solved using autologous donor adult stem cells, therapeutic cloning, stem cell banks or more recently by reprogramming of somatic cells with defined factors (e.g. induced pluripotent stem cells).

Although many immunosuppressive strategies have failed, the recent use of autologous hematopoietic stem and progenitor cell (HSPC) transplantation has shown therapeutic promise.

\ n \ nWhile historically there had been a ban on taxpayer funding of embryonic stem cell research, there has never been a ban on private funding in this country and many European countries have allowed this type of research for years, but so far none of this research has yielded a single therapeutic use.

Along with a number of other benefits to using body fat as a source of therapeutic cells, Okyanos doctors are able to gain access to Adipose - Derived Stem and Regenerative Cells (ADRCs) in a safe and minimally - invasive way utilizing a modified water - assisted liposuccells, Okyanos doctors are able to gain access to Adipose - Derived Stem and Regenerative Cells (ADRCs) in a safe and minimally - invasive way utilizing a modified water - assisted liposucCells (ADRCs) in a safe and minimally - invasive way utilizing a modified water - assisted liposuction.

The therapeutic promise of stem cell research rests on using pluripotent stem cells, which can be grown into many of the types of cells found in the human body.

In fact, professed familiarity with stem cell research in the prior question turned out to be a leading indicator of actual ignorance with respect to this question of therapeutic uses.

The exploration of the therapeutic potential of stem cells requires the characterization of their biological properties, the deciphering of the mechanisms that underlie their pluripotency and their capacity at differentiation, by the understanding of the signals that direct their fate towards discrete cell phenotypes... Their therapeutic use requests further, in particular in the case of substitutive therapies, the analysis of their capacities of integration in injured adult tissues and of their potential tumorigenicity, as well as the development of original ways of delivery.

I - Stem teams are involved in collaborative networks with many research teams both academic and industrial, in programs concerning various aspects of the therapeutic use of pluripotent stem ceStem teams are involved in collaborative networks with many research teams both academic and industrial, in programs concerning various aspects of the therapeutic use of pluripotent stem cestem cells.

Clinical studies have assessed have assessed fetal tissues as a therapeutic treatment for HD [2 - 4], although these present with problems which may be overcome by the use of induced pluripotent stem cells (iPSCs)[5].

With this backdrop of «stem cell treatments as here and ready use,» people, when faced with an incurable condition with no therapeutic solutions, turn to stem cell research - which appears to be offering all the solutions.

While pluripotent stem cell - based therapies are an exciting option, this approach has several barriers to its application, although Iqbal Ahmad (University of Nebraska Medical Center, USA) has now proposed the use of a «non ‐ cell autonomous» reprogramming strategy as a new and improved therapeutic approach [2].

Asterias maintains an extensive global intellectual property portfolio including broad issued claims to fundamental platform technologies including, but not limited to, scalable growth of pluripotent stem cells, methods of production and compositions of matter for several hESC - derived therapeutic cell types, and cellular immunotherapy using the telomerase antigen.

The public are surrounded by over-inflated representations of stem cell research and its readiness for therapeutic use.

He was also a Fulbright Scholar, and was part of the team that cloned the world's first human embryo, as well as the first to successfully generate stem cells from adults using somatic - cell nuclear transfer (therapeutic cloning).

The patented discovery comes from Novocell's recognized research & development programs to commercialize pluripotent stem cells for broad research and therapeutic uses, in particular, for an innovative cell therapy for the treatment of diabetes.

While many important developments impacted the field, two that garnered significant public, political and scientific attention in 2016 were the proliferation of clinics using unproven stem cell «therapies,» and the steps forward in therapeutic modification of human oocytes (unfertilized eggs) through a process called mitochondrial replacement therapy (MRT).

His ultimate aim is to harness the regenerative capacity of these adult stem cells for therapeutic use.

SOX2 is one of two key genes researchers use to generate induced pluripotent stem cells (iPSCs), which are capable of differentiating into all cell types for research and potential therapeutic applications.

Researchers using a novel technique find that potential therapeutic worth of mesenchymal stem cells is linked to their motility

Sorting breast cancer cells using a new reporter construct allows the interrogation of a highly pure population of cancer stem cells and may allow for the discovery of new therapeutic targets

Studies using a mouse model of type 1 diabetes highlight a potential role for human adipose stem cells in treatment regimens and, further, they reveal a secreted factor which has important therapeutic relevance

Some of the long term aims of the studies are (i) to contribute to the understanding of the mechanisms that control cortical development and evolution, (ii) to use the knowledge to grow neural stem cell populations of high purity and viability for therapeutic approaches and (iii) to study how neural stem cells can be activated in vivo.

Helmsley expanded support with an additional $ 15 million grant in 2010 to create a collaborative stem cell project involving Salk and Columbia University to fast - track the use of induced pluripotent stem cells to gain new insight into disease mechanisms and screen for novel therapeutic drugs.

Furthermore, the finding that blood cells can be used to derive iPS cells [78] may remove the need for invasive patient biopsies required for the collection of somatic cells and accelerate the ethical production of stem cell - derived tissue for therapeutic use.

An international team of researchers, funded by Morris Animal Foundation, has shown that adipose (fat) stem cells might be the preferred stem cell type for use in canine therapeutic applications, including orthopedic diseases and injury.