Sentences with phrase «therapeutic vaccine»
A therapeutic vaccine is a type of medicine that is designed to help treat and potentially cure certain diseases. It works by using specific substances to stimulate a person's immune system to fight against the disease and help them get better. Full definition
The heart disease shot Some of the new therapeutic vaccines are actually designed to attack the body, albeit in a selective way.
discovermagazine.com
Other therapeutic vaccines to treat cancer have not had the kind of potency that we've described with T cells that can kill many times.
They are exploiting a growing understanding of the immune system to develop therapeutic vaccines: ones aimed not at preventing infection but at rooting out established disease or even changing how the body functions.
The second focus on my research is the development of novel therapeutic vaccine approaches for cancer.
The DNA - based vaccine for canine melanoma was the first ever therapeutic vaccine approved for cancer — in either dogs or humans.
So far, Inovio has made the most progress with a so - called therapeutic vaccine — one that helps defeat a disease even after a patient has been diagnosed — for human papilloma virus, or HPV.
This includes utilizing a modified chimpanzee virus as a vaccine carrier to induce an immune response against HIV, and a new therapeutic vaccine against human papillomavirus (HPV), a leading cause of cervical cancer.
The lack of potent, but at the same time non-toxic and biodegradable adjuvants has been a major limitation in the development of therapeutic vaccines.
Researchers at the University of Michigan have had initial success in mice using nanodiscs to deliver a customized therapeutic vaccine for the treatment of colon and melanoma cancer tumors.
These include therapeutic cancer vaccines like Provenge ®, which received FDA approval in April 2010 for the treatment of advanced prostate cancer, and more than a dozen other therapeutic vaccines in development for brain, breast, colon, kidney, and ovarian cancers.
The researchers plan to intensively study the immune responses generated by therapeutic vaccines, broadly neutralizing antibodies, and latency reversing agents in both acutely infected individuals and also in preclinical studies.
«Nevertheless, this is a potentially exciting finding and it is possible that nivolumab, most likely in combination with other approaches such as therapeutic vaccines, may have a role in the eventual discovery of a cure for HIV.»
Physicians with the Personalized Medicine Program at The Tisch Cancer Institute have initiated a phase I proof - of - concept study, a fully personalized multipeptide therapeutic vaccine designed to target tumor - derived neoantigens for individual patients.
Gad Berdugo, CEO of EpiVax Oncology, says that such therapeutic vaccines could be used in combination with checkpoint inhibitors or, potentially, as single agents.
Knowing how to induce antiviral T cells displaying CXCR5 will be important for designing better therapeutic vaccines, as well as efforts to suppress HIV long - term, says Rama Rao Amara, PhD, professor of microbiology and immunology at Yerkes National Primate Research Center and Emory Vaccine Center.
Kwak has developed anti-cancer therapeutic vaccines to spark an immune system attack against tumors, but their effectiveness has been hindered by factors such as MDSCs that stifle immune response.
Of more than 50 therapeutic vaccine trials so far, this is the first one that has bolstered the immune system in a «meaningful» way, says Steven Deeks, an HIV / AIDS clinician and researcher at the University of California, San Francisco, who is «cautiously optimistic» that the data will inspire others to study the approach.
One of the most contentious and closely scrutinized decisions before the FDA concerns Provenge, a proposed therapeutic vaccine made by Dendreon for use against prostate cancer.
Unlike prophylactic vaccines, which prevent diseases, therapeutic vaccines fight diseases after an individual is infected in a process known as immunotherapy.
After 20 years of focused HIV vaccine research, the development of an effective HIV preventive or therapeutic vaccine remains elusive.
The current emphasis is in developing dendritic cell - based therapeutic vaccines.
We have validated the glycosphingolipid - binding non-toxic B - subunit of Shiga toxin as a delivery tool for cancer immunotherapy, and are currently building therapeutic vaccine prototypes for breast and head - and - neck cancers.
Provenge and other therapeutic vaccines involve personalized therapy that targets the patient's specific tumor.
It is focused on the development of preventive and therapeutic vaccine products and cancer drugs for patients with unmet medical needs.
Researchers have also tested so - called therapeutic vaccines, which aim to help infected people keep the virus at bay for months or even years without antiretroviral (ARV) drugs.
In the spring of last year, the FDA approved Provenge, a vaccine that beats back prostate cancer and is the first of the new generation of therapeutic vaccines to go into widespread use.
A new therapeutic vaccine, GTL001, developed by Genticel to clear HPV strains 16 and 18 — the types most likely to cause cancer — is being evaluated for safety in a Phase I clinical trial at the University of Louisville.
A 2010 survey by the market analysis firm BCC Research identified 113 therapeutic vaccines in development, many already in human trials.
«We have made many prophylactic and therapeutic vaccines for use in human clinical trials.»
They're basically «souped up» and have much more proliferative capacity than those that that have been elicited with other therapeutic vaccines.
SAN FRANCISCO — A therapeutic vaccine against severe rotaviral diarrhea, which kills nearly 900,000 infants worldwide each year, has succeeded in clinical trials.
«Cancer vaccines are the stalking horses for therapeutic vaccines,» says cancer immunologist Lloyd Old.
He points to the disastrous results of a small patient trial using an experimental Alzheimer's vaccine, a related type of therapeutic vaccine.
«It's difficult to measure immune cell responses to therapeutic vaccines, but we believe that clinical studies could tell us more about the value and function of the vaccines if we check for the response in the lesions, where the immune system is fighting precancerous cells,» says Connie Trimble, M.D., associate professor of gynecology and obstetrics, oncology and pathology at Johns Hopkins» Kimmel Cancer Center.
The committee was split evenly on whether the development of a vaccine to prevent hepatitis C would also meet the standard, but agreed that under the criteria neither development of a therapeutic vaccine nor of drugs to treat hepatitis C could justify the use of chimpanzees.
A therapeutic vaccine would not be intended to prevent the disease but rather to help patients» immune systems mobilize against the cancer cells, without recourse to surgery or radiation.
Moreover, the complex compound acts as a therapeutic vaccine which activates the immune system against the reservoir cells hosting the parasite.
Physician scientists want to know if a new therapeutic vaccine can prevent or reduce recurrence of cervical cancer in women at high risk for its return.
Through strategic partnerships with industry and nonprofit organizations, we gain access to a portfolio of priority drugs for testing within our expert focus groups, including checkpoint inhibitors, therapeutic vaccines, innate immune stimulants, targeted therapies, and many other promising treatments and technologies with high therapeutic potential.
Current immunotherapies for ovarian cancer fall into six broad categories: monoclonal antibodies; checkpoint inhibitors and immune modulators; therapeutic vaccines; adoptive T cell transfer; oncolytic viruses; and adjuvant immunotherapies.
As Vice President Research at Hookipa, Dr. Klaus Orlinger is responsible for generation and characterization of prophylactic and therapeutic vaccines / immunotherapy candidates.
Vaxwave ® is focused on the development of prophylactic vaccines to prevent infectious diseases and TheraT ® enables Hookipa to develop immuno - oncology therapies and therapeutic vaccines.
Lizée and colleagues are developing a different type of vaccine called a therapeutic vaccine, which triggers an attack against established cancer.
Therapeutic vaccines are designed to elicit an immune response against tumor - specific or tumor - associated antigens, encouraging the immune system to attack cancer cells bearing these antigens.
These treatments can be broken into 7 main categories: checkpoint inhibitors / immune modulators, therapeutic vaccines, adoptive cell transfer, monoclonal antibodies, oncolytic viruses, adjuvant immunotherapies, and cytokines.
A phase 2 study of the therapeutic vaccine is currently underway in other centers in patients with recurrent disease to see if it can help extend 12 - month survival.