Mario Renato Iwakura recently sent me a link to a paper that nicely illustrates the potential of antiviral
therapies against cancer.
Many different immunology - based
therapies against cancer have been investigated, but most have produced only limited clinical benefits.
Other Institutions also belong to the Campus: the University of Milan; Cogentech, an IFOM - IEO consortium committed to developing leading genomic technologies (nanotechnologies, proteomics, bioinformatics, disease models), the European School of Molecular Medicine (SEMM), that organizes training in emerging sectors of Biomedicine, offering the first European PhDs in Molecular Medicine, Medical Nanotechnologies, Foundations of the Life Sciences and their Ethical Consequences; Genextra, a biotech company whose mission is to develop new
therapies against cancer and aging - related disease; Biopolo, a not for profit company involved in the technological transfer of basic research to the productive system.
«Harnessing power of immune system for
therapies against cancer.»
Maybe if virus - related cancers have methylated DNA promoter regions of immune - related genes, the answer to increasing the effectiveness of immune - based
therapies against cancer is to demethylate these genes.
This new understanding may help to increase the effectiveness of immune - based
therapies against cancer.
Nrp1 may provide an important hub for the development of new
therapies against cancer.
In the end, a vaccine will probably need to take multiple approaches at once, like combination
therapy against cancer, says Jeffery Taubenberger of the National Institute of Allergy and Infectious Diseases.
Neoantigens are molecules on cell's surfaces that are produced by DNA mutations that are present in cancer cells but not in normal cells, making neoantigens ideal targets for immune
therapy against cancer, say the scientists.
Not exact matches
The premise is simple: you send cookies to 3 other food bloggers and get 3 dozen cookies from 3 different food bloggers in return... and best of all, we get to support Cookies For Kids»
Cancer, a national non-profit organization that funds new therapies used to fight against pediatric c
Cancer, a national non-profit organization that funds new
therapies used to fight
against pediatric
cancercancer!
This non-profit organization commits to funding new
therapies used in the fight
against pediatric
cancer.
While justifying his call for allocation of oil block to
cancer treatment, he said a Mevavoltage
cancer therapy machine is available for 33 million Nigerians as
against four to about 200,000 Australians, adding, «most patients have little or no access to Radiation Oncology services».
Nonetheless, Sonntag plans to study whether short - term
therapy with either hormone might protect people
against cognitive damage from stroke without causing
cancer.
On its own, this immune response had no immediate effect in the fight
against the utilized breast tumors, but in combination with the ADC it proved itself effective in attacking
cancer cells in mice, resulting in the complete cure of the majority of mice receiving the combination
therapy.
Now a University of Colorado
Cancer Center study published online ahead of print in the journal Oncogene offers compelling evidence explaining this failure and offering a possible strategy for the use of retinoic acid or other retinoids against some breast cancers: Because early clinical trials are often offered to patients who have already tried other more established therapies, breast cancer cells may have been pushed past an important tipping point that offers retinoic acid resis
Cancer Center study published online ahead of print in the journal Oncogene offers compelling evidence explaining this failure and offering a possible strategy for the use of retinoic acid or other retinoids
against some breast
cancers: Because early clinical trials are often offered to patients who have already tried other more established
therapies, breast
cancer cells may have been pushed past an important tipping point that offers retinoic acid resis
cancer cells may have been pushed past an important tipping point that offers retinoic acid resistance.
Last year, the FDA approved for use
against lung
cancer two antibody - based
therapies that block PD - 1.
Breast
cancer patients may be at an increased risk of cardiovascular diseases including heart failure and may benefit from a treatment approach that weighs the benefits of specific
therapies against potential damage to the heart, according to a new scientific statement from the American Heart Association published in its journal Circulation.
«Genes may cause tumor aggressiveness, drug resistance in African - American prostate
cancer: Research found many targeted
therapies for prostate
cancer may not be effective
against tumors in African - American men.»
A showdown over a controversial
cancer therapy has intensified, pitting Brazil's scientists
against its congress.
«I am so happy that more of these types of nanoparticle - based hyperthermal
therapies are being developed to increase the arsenal of weapons
against cancer.»
It showed effectiveness
against liver
cancer in a phase II clinical trial and will move into a phase III trial later this year, David Kirn, an oncologist and the company's president and chief executive officer, said at a recent meeting of the American Society for Gene & Cell
Therapy in Washington, D.C..
Building on these successes, gene
therapy may soon be used to correct hereditary genetic diseases like cystic fibrosis, hemophilia, and Tay - Sachs and to activate the immune response
against a wide variety of infectious diseases and
cancers.
This makes the development of an effective vaccine to protect
against infection, as well as antiviral
therapy to combat already - existing infections, particularly challenging,» says Dr. Grant Hansman, a virologist who leads the CHS Research Group on Noroviruses at the German
Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and Heidelberg University.
All of which means that story number 2 about green tea improving
therapy against a couple of
cancers is TOTALL....
CureVac's most advanced project is a prostate
cancer therapy that is now entering a second phase II clinical study; a vaccine
against rabies is in phase I tests.
The authors said their results, which they have made publicly available, constitute an invaluable resource to help clinicians predict which chemotherapies will be most effective
against tumor cells with particular genetic mutations, and how to rationally combine
therapies to prevent
cancers from developing resistance.
The test, described in tomorrow's issue of the journal Circulation, might be used to devise better antioxidant vitamin
therapies against free radicals and to explore the mechanism of these compounds in
cancer and other diseases.
By viewing this fusion as another disease imposed onto tumor cells, scientists could devise new
therapies against metastasis, the researchers say in the May Nature Reviews
Cancer.
Therefore, the insights of Dr. Melendez and her colleagues may deepen our understanding of
cancer and aid in the development of
therapies against malignant cell growth.
For patients, down the road Dr. Ohashi envisions a new era of combined
therapies to simultaneously target and kill these suppressive cells while augmenting the immune response
against cancer.
Kole Roybal is the 2018 grand prize winner of the inaugural Sartorius & Science Prize for Regenerative Medicine & Cell
Therapy, for developing a new class of T cell immunotherapies that can be fine - tuned to better help the immune system recognize
cancer and initiate precise therapeutic action
against the disease.
«Nanoparticles combine photodynamic and molecular
therapies against pancreatic
cancer: Novel drug - delivery system cuts off common treatment escape pathways in animal models.»
«People have been targeting telomerase as a potential
cancer therapy for a long time,» he says, noting that anti-telomerase drugs are in phase II clinical trials
against several
cancers.
Because of the urgent needs of a large number of
cancer patients, most of these gene
therapy trials are directed
against cancer.
Most patients don't know that in clinical trials new
cancer therapies are tested
against the standard of care, not a placebo.
«Combination
therapy may be more effective
against the most common ovarian
cancer.»
Androgen deprivation
therapy is a powerful tool
against prostate
cancer, and more and more men are opting for the treatment as a growing array of hormone - based
therapies become available.
They are examining every aspect of cell function and cell structure, looking for clusters of phenotypes that could label a patient's
cancer so precisely that it could be linked to
therapies proven effective
against just that type.
In particular, more work is needed to determine the safety of this
therapy in advanced mouse models that can more accurately predict safety in humans, and its efficacy specifically
against metastatic
cancer, which is the leading cause of
cancer - related deaths.
«Identifying a
cancer driver is crucial for
cancer treatment because it allows the use of targeted
therapies, which have less side - effects than conventional chemotherapy drugs,
against a particular protein,» said Kurokawa.
Vaccination
against ED - A could therefore provide a treatment strategy with broad applications in
cancer therapy.
«If our findings are confirmed by additional studies, they may open doors to the development of targeted
therapies against the tumor subtypes more likely to affect African Americans and potentially help reduce racial disparities in breast
cancer.»
«Since doxorubicin is one of the cheapest drugs that is effective
against many types of
cancer but rarely used in colon
cancer, the combination
therapy could be highly effective in combating colon
cancer while drastically lowering risk of cardiotoxic side effects.»
In the present study, the scientists demonstrated that the drug BI-97D6 increased
cancer cell death caused by mda - 7 / IL - 24, and it also helped defend
against resistance to the viral gene
therapy.
In 2012, the St. Jude Children's Research Hospital — Washington University Pediatric
Cancer Genome Project highlighted DDX3X as a promising focus for efforts to develop targeted
therapies against medulloblastoma.
Aptamers are also being selected
against specific cellular receptors for use in
cancer therapy.
The results in dogs allowed the scientists to advance PAC - 1 as a potential
therapy against human
cancers.
«Going to «Wars»
against cancer, heart disease: Uncovered gene may provide target for new
therapies.»
An international research team led by Université de Montréal medical professor Christopher Rudd, director of research in immunology and cell
therapy at Maisonneuve - Rosemont Hospital Research Centre, has identified a key new mechanism that regulates the ability of T - cells of the immune system to react
against foreign antigens and
cancer.
It's only three patients on a low dose of cells, but San Diego - based Poseida said the results — activity
against the
cancer and no «cytokine storm» side effects that often come with CAR - T
therapy — were good enough to step up to the next dose.