Not exact matches
February 2, 2017
By Ann Perry http://mbd.utoronto.ca/ When Arif Aziz learned last fall about a new independent study project that was bringing together MBA candidates and PhD students in health sciences and
engineering to map the global market for stem cell
therapies, he jumped at the opportunity.
By varying the compositions of lipids, cues, and diffusible factors in the scaffolds, we
engineered a very versatile and flexible platform that can be used to amplify specific T cell populations from blood samples, and that could be deployed in existing
therapies such as CAR - T cell
therapies,» said Mooney, Ph.D., a Core Faculty member at the Wyss Institute and leader of its Immunomaterials Platform.
To strengthen its clinical research profile, Dresden has created a strategic plan, to be funded
by the German Research Ministry (BMBF), that focuses on three aspects of clinical research: tissue
engineering and development of physical and molecular medical technologies for clinical application; therapeutic strategies after cell and tissue damage; and diagnosis and
therapy of malignant diseases.
The proposed clinical trial, in which researchers would use CRISPR to
engineer immune cells to fight cancer, won approval from the Recombinant DNA Advisory Committee (RAC) at the U.S. National Institutes of Health, a panel that has traditionally vetted the safety and ethics of gene
therapy trials funded
by the U.S. government and others.
As demonstrated
by the breadth of clinical trial involvement shown above, CCIR members are testing the utility of immune checkpoint blockade in lymphoma (shown
by Dr. Allison to be effective against melanoma), genetic
engineering in cell
therapy (e.g., CD19, CXCR2, TGF - β DNR), and TLR agonists or IL - 2 in vaccine formulations as well as some novel combination
therapies, such as the infusion of tumor - reactive lymphocytes from HLA - matched donors who were vaccinated with a lymphoma idiotype.
These partnerships foster the exchange of scientific and
engineering knowledge and broaden the development of students and faculty and
by encouraging them to pursue technologies related to regenerative medicine and training clinicians in the implementation of regenerative
therapies.
Thus, this rational transcript
engineering approach may represent a unique therapeutic opportunity for a wide range of diseases caused
by mutations in the mitochondrial genome for which current effective
therapies are lacking (2)
He is a major donor to and serves as an advisor to the Methuselah Foundation, dedicated to extending the healthy human lifespan
by advancing tissue
engineering and regenerative medicine
therapies.
Here, we address that unmet need for cell
therapy biomanufacturing, in part
by leveraging existing decision -
engineering frameworks for biopharmaceuticals to build on the nascent body of published work geared towards cell
therapies.
Prof. Su's current research fields include the design, the synthesis, the property study and the molecular
engineering of nanostructures and highly organized and hierarchically self - assembled porous materials, bio-integrated living and bio-inspired materials including leaf - like materials
by the immobilization of living organisms and biomaterials for catalysis, photocatalysis, CO2 reduction and water splitting, artificial photosynthesis, nanotechnology, biotechnology, information technology, energy storage and conversion, cell
therapy and biomedical applications.
Furthermore,
by combining this information with the characterization of mice genetically
engineered to develop lung tumours, we attempt to elucidate the key genes driving lung cancer initiation, progression and response to
therapy.
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