«Effect of 12 months of whole - body vibration
therapy on bone density and structure in postmenopausal women: a randomized trial.»
Not exact matches
Previous studies have revealed the positive impact of menopausal hormone
therapy (MHT)
on bone mineral
density.
Topics such as the mechanisms of cell injury in normal and dystrophic muscle, compensatory muscle regeneration and hypertrophy, and the effects of various
therapies or voluntary exercise
on muscle repair, satellite cell activation, muscle growth,
bone density and age - related atrophy are examined using a large variety of cellular, molecular and whole - animal in vivo assays of function.
Potential cardioprotection was based
on generally supportive data
on lipid levels in intermediate outcome clinical trials, trials in nonhuman primates, and a large body of observational studies suggesting a 40 % to 50 % reduction in risk among users of either estrogen alone or, less frequently, combined estrogen and progestin.2 - 5 Hip fracture was designated as a secondary outcome, supported by observational data as well as clinical trials showing benefit for
bone mineral
density.6, 7 Invasive breast cancer was designated as a primary adverse outcome based
on observational data.3, 8 Additional clinical outcomes chosen as secondary outcomes that may plausibly be affected by hormone
therapy include other cardiovascular diseases; endometrial, colorectal, and other cancers; and other fractures.3, 6,9
Analysis of several studies
on the effect of combined progestin - estrogen
therapy indicates that progestins do appear to improve
bone density, but their use is accompanied by a long list of unacceptable potential side effects.