«First embryonic stem cell
therapy safety trial in Asian patients.»
Not exact matches
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical
trials involving investigational compounds; Gilead's ability to initiate clinical
trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell
therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other
therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs;
safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
No. 4: CAR - T takes a backseat Research into chimeric antigen receptor T - cell (CAR - T)
therapy has captured the attention of investors over the past two years, but
safety risks could emerge as
trial sizes increase, and that could help shift attention to other promising anti-cancer approaches, including NantKwest's (NASDAQ: NK) natural killer cell approach and soon - to - IPO Editas» CRISPR / Cas approach.
The researchers caution that the booster
therapy used in their new study will not be available on the market or even for use in human
trials anytime soon; it must await years of animal testing for
safety and effectiveness first.
Although gene
therapy research has made great strides in recent years, it has yet to be widely deployed, and no CRISPR - edited genes have yet been tested for
safety or efficacy in human clinical
trials.
The CO-STAR (Hepatitis C Patients on Opioid Substitution
Therapy Antiviral Response)
trial sought to evaluate the efficacy and
safety of elbasvir - grazoprevir for injection drug users.
The
trial he conducted tested the
safety of a
therapy for ornithine transcarbamylase (OTC) deficiency, a rare disorder in which the liver lacks a functional copy of the OTC gene.
It typically takes many years to initiate such
trials because of the stringent
safety testing that must be done before testing in humans begins, but Reynolds said it may be possible to move faster as the
therapy only involves modifying a patient's dietary intake and supplementing with a medium - chain triglyceride oil, both of which have no known side effects.
Research groups at universities and hospitals need to meet strict
safety guidelines for clinical
trials but some small private clinics are offering
therapies to people without research or marketing approval.
These results are especially remarkable given that Cannata was participating in a Phase I
safety trial that delivered the
therapy at a relatively low dose.
The phase I and phase I / II
trials aimed to measure the
safety of adding HCQ to either chemotherapy, radiation
therapy or targeted
therapies, its effectiveness at inhibiting autophagy, and the potential clinical benefit of HCQ combination
therapies.
The data
safety monitoring board of the
trial, as mandated by the study protocol, continues to monitor outcomes in patients with a Recurrence Score of 11 to 25 randomized to chemo - endocrine
therapy or endocrine
therapy alone.
The proposed clinical
trial, in which researchers would use CRISPR to engineer immune cells to fight cancer, won approval from the Recombinant DNA Advisory Committee (RAC) at the U.S. National Institutes of Health, a panel that has traditionally vetted the
safety and ethics of gene
therapy trials funded by the U.S. government and others.
A clinical
trial in the Republic of Korea for patients with degenerative eye diseases is the first to test the
safety of an embryonic stem cell
therapy for people of Asian descent.
The
therapy was found to have an acceptable
safety profile in all patients, with no clinical or laboratory signs of systemic cytokine release syndrome, a potentially serious toxicity that has been observed in other CAR
trials.
In the current
trial, two patients experienced an immune response to the gene
therapy that did not result in
safety concerns, and were treated with steroids.
Two new phase III clinical
trials investigating the efficacy and
safety of bitopertin, a glycine uptake inhibitor considered to be a promising new add - on
therapy for treating negative symptoms in schizophrenia, failed to show a benefit of the drug over placebo.
If these preclinical studies are successful, the researchers plan to further develop their CAR T cell
therapy and test its
safety and efficacy for different types of metastatic cancer in upcoming clinical
trials.
Dr. Timmerman, who holds the Effie Marie Cain Distinguished Chair in Cancer
Therapy Research, has championed the use of SABR globally and has served as the lead investigator in several national
trials designed to evaluate the efficacy and
safety of SABR to treat cancer in the lung, liver, spine, and prostate.
Stricter
safety procedures and new ways to weaken pathogens to reduce their risks are leading investigators in industry, universities, and government to take a new look at human challenge
trials, which offer a powerful tool for studying diseases and potential
therapies.
George notes, «Our goal in this
trial was to evaluate the
safety of the gene
therapy product and secondarily, to determine if we could achieve levels of factor IX that could decrease bleeding events in patients.»
Women were not included in the first
trial of gene
therapy, which was mainly concerned with proving the
safety of the technique.
The ENGOT - OV16 / NOVA
trial evaluated the efficacy and
safety of the PARP inhibitor niraparib as maintenance
therapy in patients with recurrent ovarian cancer who respond to platinum - based chemotherapy.
Fischer also suspended his gene
therapy trials to solve
safety issues.
«The first year results from the CoreValve US Pivotal
Trial support the
safety and efficacy of this
therapy in patients unsuitable for surgical aortic valve replacement,» said lead investigator Steven Yakubov, MD..
But many projects come under public and federal scrutiny — the recent fracas over gene
therapy trials is a case in point (Science, 24 March, p. 2163), often because the manner in which they were conducted led to concerns over the
safety of the recruited participants or the protection of their confidentiality.
To create a longer - lasting preventive
therapy for severe hemophilia A-associated bleeding, a group of Japanese researchers launched a first - in - human Phase I
trial to evaluate the
safety, tolerability, pharmacokinetics, and pharmacodynamics of ACE910, a bispecific antibody that mimics FVIII and works with other clotting factors to make the blood clot properly.
For very rare diseases such as WAS, multicenter clinical
trials are the only effective way of proving the
safety and efficacy of gene
therapy and having it rapidly approuved and made available to all patients.
The research, part of a phase I clinical
trial to test the
safety of the treatment, was published as a letter to the editor in The New England Journal of Medicine earlier this week and will be in the September issue of Human Gene
Therapy.
In contrast, the
safety record of hematopoietic stem cell gene
therapy is less clear, with a significant frequency of gene -
therapy induced oncogenesis or clonal outgrowth reported in several hematopoietic stem cell
trials [56], [57].
If their phase I clinical
trial to test the
safety and preliminary efficacy of this
therapy gains approval, University of Pittsburgh researchers will test the
therapy on 10 patients who suffer from chronic ischemic stroke — the most common form, in which clots block blood flow.
A Randomized, Phase III
Trial to Evaluate The Efficacy and
Safety of MK - 3475 (Pembrolizumab) as Adjuvant
Therapy for Triple Receptor - Negative Breast Cancer with ≥ 1 cm Residual Invasive Cancer or Positive Lymph Nodes (yPN +) After Neoadjuvant Chemotherapy
The CBER is already utilizing in silico techniques to predict clinical outcomes and product
safety, inform clinical
trial designs, and optimize dosing, and is also implementing the Regenerative Medicine Advanced
Therapy (RMAT) designation which provides resources to expedite promising regenerative medicines that address unmet needs.
«With so few patients aged 75 or older enrolled in clinical
trials, critical information on the
safety and effectiveness of new
therapies in this age group is greatly lacking,» she said.
The goal of phase - I
trials is to determine the
safety and toxicity of a new
therapy.
The first - in - human STEP ONE *
trial is evaluating the
safety and efficacy of ViaCyte's PEC - Encap (a.k.a. VC - 01 ™) product candidate, a stem cell - derived, encapsulated cell replacement
therapy.
Yesterday a team of University of Pennsylvania researchers — led by Dr Pablo Tebas, Professor Carl June, and Dr Bruce Levine — announced the successful conclusion of a clinical
trial to evaluate the
safety of a new gene
therapy technique for treating HIV.
«We have been very concerned about reports of patients using unproven medical
therapies whose
safety and efficacy have not been tested in systematic clinical
trials,» he said.
ViaCyte's VC - 01 ™ product candidate, a first - in - class cell replacement
therapy for the treatment of type 1 diabetes, is currently being evaluated in a Phase 1/2
trial called STEP ONE, or
Safety, Tolerability, and Efficacy of VC - 01 Combination Product in Type One Diabetes.
Paris, France, April 3, 2018, 5.35 pm CET — GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA - PME eligible), a biopharma company focused on discovering and developing innovative gene
therapies for retinal neurodegenerative diseases and central nervous system disorders, today announced topline results from the REVERSE Phase III clinical
trial evaluating the
safety and efficacy of a single intravitreal injection of GS010 (rAAV2 / 2 - ND 4) in 37 subjects whose visual loss due to 11778 - ND4 Leber Hereditary Optic Neuropathy (LHON) commenced between 6 and 12 months prior to study treatment.
The ISSCR believes that the
safety and efficacy of all stem cell and regenerative medicine
therapies should be proven in systematic clinical
trials, reviewed by the FDA, before they are sold to patients.
Overall, SR - Tiget represents a multi-disciplinary research environment, which provides a unique blend of scientific expertise in the development of innovative gene and cell
therapy strategies, access to relevant preclinical models to evaluate their efficacy and
safety, as well as competence in conducting early phase clinical
trials.
These centers specialize in conducting clinical
trials to evaluate the
safety and effectiveness of new CF
therapies.
Immune Design entered into clinical collaboration agreements with Merck, known as MSD outside the U.S. and Canada, to evaluate the
safety and efficacy of two Immune Design immuno - oncology investigative agents, G100 and LV305, separately combined with KEYTRUDA ® (pembrolizumab), Merck's anti-PD-1
therapy, in Phase 1
trials in patients with non-Hodgkin's lymphoma (NHL) and melanoma, respectively.
Eugene Fine was also there with a poster on his just published pilot study on ketogenic diets and cancer — «Targeting insulin inhibition as a metabolic
therapy in advanced cancer: A pilot
safety and feasibility dietary
trial in 10 patients.»
Targeting insulin inhibition as a metabolic
therapy in advanced cancer: a pilot
safety and feasibility dietary
trial in 10 patients.
Seeking
Safety therapy for adolescent girls with PTSD and substance use disorder: A randomized controlled
trial.
This randomized clinical
trial tests the
safety and efficacy of daily vs intermittent antituberculosis
therapy in HIV - positive patients.