Although the study's approach wasn't a sure bet, the researchers hoped to go further than any other gene
therapy trial yet for this relatively common inherited disease that fills people's lungs with sticky mucus that promotes deadly infections.
Not exact matches
To date, no gene
therapies have
yet been approved in the US, though one to treat another form of LCA has had promising results in late - stage
trials.
The case was
yet more evidence that both the clinical
trial doctors and the drug's developers would have to be more patient in assessing this new type of
therapy.
Although gene
therapy research has made great strides in recent years, it has
yet to be widely deployed, and no CRISPR - edited genes have
yet been tested for safety or efficacy in human clinical
trials.
«Our gene
therapy protocol is not
yet ready for clinical
trials — we need to tweak it a bit more — but in the not - too - distant future we think it could be developed for therapeutic use in humans,» says Jeffrey Holt, PhD, a scientist in the Department of Otolaryngology and F.M. Kirby Neurobiology Center at Boston Children's and an associate professor of Otolaryngology at Harvard Medical School.
Yet few among us today have not benefited from such
trials, whether the lessons were positive (e.g., the benefits of an aspirin a day to reduce heart - attack risk) or negative (e.g., the increased risk of cancer associated with long - term hormone - replacement
therapy).
There are a number of medical
therapies that seem to help CLM / SM dogs with both pain management and scratching activity, but there are no controlled clinical
trials published
yet to objectively measure the efficacy / inefficacy of these treatments.
Risk of relapse among patients diagnosed with major depressive disorder is high (> 50 % of those recovering from a first episode of depression, and approximately 80 % of those with a history of two or more episodes), 1 and this risk increases with each successive depressive episode.2 Several clinical
trials have demonstrated that mindfulness - based cognitive
therapy (MBCT) significantly reduces relapse risk among patients with three or more prior depressive episodes.3
Yet, MBCT contains multiple therapeutic elements, and the specific efficacy of the mindfulness training element in MBCT is unknown.
Trials of cognitive — behavioural
therapy (CBT), dialectic behaviour
therapy (DBT), mentalisation - based
therapy and family
therapy are
yet to report results.
And though the findings of our open
trial described above are suggestive, they do not
yet prove things... This is the main reason we embarked on the (currently - running) international RCT of group - ST for BPD (Wetzelaer et al., 2014), which examines this question empirically by comparing group ST in two formats (combined with individual
therapy vs. intensive group
therapy alone) to treatment - as - usual.